Poly vinyl acetate and ammonio methacrylate copolymer as unconventional polymer blends increase the mechanical robustness of HPMC matrix tablets

A new design for a chronological release profile of etodolac from coated bilayer tablets: In-vitro and in-vivo assessment

“…Eventually, this thorough diffusion led to swelling of the polymer layer forming a high viscosity gel matrix. The presence of HPMC K4M in the swellable layer led to an increased hydration, which in turns resulted in higher swelling degree and erosion [27]. The innermost coating layer adjacent to the bilayer tablet was made of OpadryII®.…”

Controlled release tablets based on HPMC:lactose blends

“…Hydrophilic matrix tablets offer an interesting potential for oral controlled drug delivery [1,2,3,4,5,6,7]. Hydroxypropyl methylcellulose (HPMC) is frequently used for this purpose [8,9,10,11,12,13,14]. Upon administration, water penetrates into the system and dissolves the drug [15,16,17].…”

Hot melt extruded polysaccharide blends for controlled drug delivery

“…Polymer blends offer an interesting potential for controlled drug delivery systems [1,2,3,4,5,6], both as matrix formers [7,8,9,10] and as coating materials [11,12,13,14,15]. By simply varying the polymer:polymer blend ratio, the resulting key properties of the systems can be effectively varied, allowing to provide large spectra of possible drug release kinetics [16,17,18].…”