Poly(sulfobetaine)s and corresponding cationic polymers. VIII. Synthesis and aqueous solution properties of a cationic poly(methyl iodide quaternized styrene–<i>n</i>,<i>n</i>‐dimethylaminopropyl maleamidic acid) copolymer

Lee, Wen‐Fu; Chen, Yanming

doi:10.1002/app.1255

Cited by 14 publications

(11 citation statements)

References 43 publications

(56 reference statements)

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“…Hence, as shown in Figure , the viscosity decreases of Cl − and Br − show a close proximity because of their similar ionic radii — of 1.7 Å and 1.87 Å, respectively, whereas a clear difference is seen in I − which has ionic radius of 2.12 Å, because they interact strongly and exhibit a low mean activity coefficient in aqueous solution . These trends are in agreement with the results obtained by Lee et al…”

Section: Resultssupporting

confidence: 90%

A NIPAM–Zwitterion Copolymer: Rheological Interpretation of the Specific Ion Effect on the LCST

Obiweluozor

GhavamiNejad

Hashmi

et al. 2014

Macro Chemistry & Physics

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The effect of various cations and anions on the ability to shield the electrostatic interaction between charged copolymers containing a non‐ionic moiety (N‐isopropylacrylamide (NIPAM)) is explored. The Hofmeister series, first noted in 1888, ranks the relative influence of ions on the physical behavior of a wide variety of aqueous processes ranging from colloidal assembly to protein folding. The viscoelastic behavior of a poly(NIPAM‐co‐Zw10%) solution as a function of ionic strength in the presence of different ions is rheologically investigated. The obtained copolymer exhibits a thermoresponsive behavior, with tunable lower critical solution temperature (LCST) ranging from 28 to 33 °C. The viscosity change specifically demonstrates the effectiveness of the low‐molecular‐weight ions in weakening the inter‐/intramolecular electrostatic crosslinks among the sulfobetaine chain and in enhancing the hydration of the macromolecule. The effectiveness of the anions follows the Hofmeister series while that of the cations follows the reversed Hofmeister series, as demonstrated by Collins' concept of “matching water affinity,” due to presence of a sulfobetaine group in the chains.

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Section: Resultssupporting

confidence: 90%

A NIPAM–Zwitterion Copolymer: Rheological Interpretation of the Specific Ion Effect on the LCST

Obiweluozor

GhavamiNejad

Hashmi

et al. 2014

Macro Chemistry & Physics

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“…This phenomenon indicates that MIQEDMAPMA has a maximum net charge repulsion under this condition. This behavior was also observed for poly(methyl iodide quaternized styrene‐dimethylaminopropyl maleamidic acid) (MIQSDMAPMA) in our previous work 52…”

Section: Resultssupporting

confidence: 81%

Poly(sulfobetaine)s and corresponding cationic polymers. XI. Synthesis and aqueous solution properties of a cationic poly(methyl iodide quaternized ethyl vinyl ether/N,N‐dimethylaminopropyl maleamidic acid) copolymer

Lee

Chen

2003

J of Applied Polymer Sci

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ABSTRACT:A copolymer prepared by the copolymerization of ethyl vinyl ether and maleic anhydride underwent amidoacidation with N,N-dimethylaminopropylamine. The obtained ethyl vinyl ether/dimethylaminopropyl maleamidic acid copolymer was then reacted with methyl iodide to yield poly(methyl iodide quaternized ethyl vinyl ether/ N,NЈ-dimethylaminopropyl maleamidic acid) (MIQED-MAPMA). The greatest difference from other polyelectrolytes was the carboxylic group on the polymer chain unit of MIQEDMAPMA. Its aqueous solution properties in various salts and at various pH values were studied by measurements of the reduced viscosity and intrinsic viscosity. The reduced viscosity and intrinsic viscosity of this cationic polyelectrolyte were related to the types and concentrations of the added salts. The tendency of the salt effect was similar to that of other polyelectrolytes; that is, soft salt anions were more easily bound to the quaternary ammonium (R 4 N ϩ ) of MIQEDMAPMA than hard salt anions. Some salt ions strongly attracted the quaternary ammonium of the cationic polymeric side chain for the agglomeration of the polymers.

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“…The amidoacidification of maleic anhydride copolymer with N , N -dimethylamino-1-propyl amine (DMAPA) was performed analogously to the model reaction [ 18 , 44 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. The amine was added dropwise to a dimethylformamide DMF solution of the copolymer.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, and Antimicrobial Properties of Peptides Mimicking Copolymers of Maleic Anhydride and 4-Methyl-1-pentene

Szkudlarek

Heine

Keul

et al. 2018

IJMS

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Synthetic amphiphilic copolymers with strong antimicrobial properties mimicking natural antimicrobial peptides were obtained via synthesis of an alternating copolymer of maleic anhydride and 4-methyl-1-pentene. The obtained copolymer was modified by grafting with 3-(dimethylamino)-1-propylamine (DMAPA) and imidized in a one-pot synthesis. The obtained copolymer was modified further to yield polycationic copolymers by means of quaternization with methyl iodide and dodecyl iodide, as well as by being sequentially quaternized with both of them. The antimicrobial properties of obtained copolymers were tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis, and Staphylococcus aureus. Both tested quaternized copolymers were more active against the Gram-negative E. coli than against the Gram-positive S. aureus. The copolymer modified with both iodides was best when tested against E. coli and, comparing all three copolymers, also exhibited the best effect against S. aureus. Moreover, it shows (limited) selectivity to differentiate between mammalian cells and bacterial cell walls. Comparing the minimum inhibitory concentration (MIC) of Nisin against the Gram-positive bacteria on the molar basis instead on the weight basis, the difference between the effect of Nisin and the copolymer is significantly lower.

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Poly(sulfobetaine)s and corresponding cationic polymers. VIII. Synthesis and aqueous solution properties of a cationic poly(methyl iodide quaternized styrene–n,n‐dimethylaminopropyl maleamidic acid) copolymer

Cited by 14 publications

References 43 publications

A NIPAM–Zwitterion Copolymer: Rheological Interpretation of the Specific Ion Effect on the LCST

A NIPAM–Zwitterion Copolymer: Rheological Interpretation of the Specific Ion Effect on the LCST

Poly(sulfobetaine)s and corresponding cationic polymers. XI. Synthesis and aqueous solution properties of a cationic poly(methyl iodide quaternized ethyl vinyl ether/N,N‐dimethylaminopropyl maleamidic acid) copolymer

Synthesis, Characterization, and Antimicrobial Properties of Peptides Mimicking Copolymers of Maleic Anhydride and 4-Methyl-1-pentene

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