Poly(sodium-4-styrene)sulfonate−Iron Oxide Nanocomposite Dispersions with Controlled Magnetic Resonance Properties

Abstract

We report synthesis and studies of magnetic suspensions with tunable low-field relaxivities. Using a one-step procedure, we have prepared magnetic fluids composed of polyelectrolyte stabilized magnetite nanoparticles. We have demonstrated the effect of varying the synthetic conditions, in particular, the iron and PSSS polyelectrolyte content for a fixed polymer chain length, on the emergent magnetic resonance properties of the iron oxide nanoparticle suspensions. The new magnetic fluids have a potential for in vivo MRI diagnostics.

Heparin-stabilised iron oxide for MR applications: a relaxometric study

“…DNA or DNA-mimics, such as poly(sodium-4-styrene) sulfonate (PSSS)) during the synthesis of magnetite nanoparticles has been observed to provide stable magnetic fluids with enhanced magnetic resonance properties. 10,[12][13][14][15] Dispersive nuclear magnetic resonance (NMRD) is a useful tool in the analysis of the relaxation properties of colloidal magnetic nanoparticles. 8,16 It can provide a quantitative assessment of the potential usefulness of a CA species in the clinical MRI frequency range .…”

Epoxy Ring Opening Phase Transfer as a General Route to Water Dispersible Superparamagnetic Fe3O4 Nanoparticles and Their Application as Positive MRI Contrast Agents

“…Secondly, they must also be biocompatible and fully dispersed in biological media without aggregation. Despite extensive efforts aimed at improving the outcome of the aqueous co‐precipitation route to MNPs,4, 5 the high temperature thermal decomposition pathways remain preferable by the first criterion. However, it is disadvantageous by the second criterion, as the particles are usually surface coated with a chemisorbed layer of aliphatic acids 6…”

Synthesis of highly loaded and well‐controlled magnetic beads via emulsion polymerization

“…The SPIO aggregation started before the latex formation, resulting in the formation of a single black piece of aggregated SPIO, whereas the PSL contained only traces of iron oxide. One of the possible explanations for the observed phenomenon can be as follows: despite the fact that both acrylic and styrenic groups are reactive to free radical polymerization and have been successfully copolymerized in a random way in many cases,27 their relative reactivity may change in the presence of SPIO. The electron density is shifted to the acetylacetone moiety when AAEM is coordinated to the iron oxide NP.…”