Poly(organophosphazenes) with oligopeptides as side groups: prospective biomaterials

Allcock, Harry R.; Chang, Ji Young

doi:10.1021/ma00005a005

Cited by 41 publications

(19 citation statements)

References 8 publications

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“…Amino acid substituted polyphosphazenes with various functional groups have been successfully synthesized [8–15]. The rate of hydrolysis for polyphosphazenes depends on the nature of the group attached to the α-carbon of the amino acid ester side group; bulkier side groups result in less hydrolytically sensitive polymers [16–20].…”

Section: Introductionmentioning

confidence: 99%

Mechanical properties and osteocompatibility of novel biodegradable alanine based polyphosphazenes: Side group effects

et al. 2010

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The versatility of polymers for tissue regeneration lies in the feasibility to modulate the physical and biological properties by varying the side groups grafted to the polymers. Biodegradable polyphosphazenes are high molecular weight polymers with alternating nitrogen and phosphorus atoms in the backbone. This study is the first of its kind to systematically investigate the effect of side group structure on the compressive strength of novel biodegradable polyphosphazene based polymers as potential materials for tissue regeneration. The alanine polyphosphazene based polymers, poly [bis(ethyl alanato) Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Moreover cells on the surface of the polymers expressed type I collagen, alkaline phosphatase, osteocalcin, osteopontin, and bone sialoprotein which are characteristic genes for osteoblast maturation, differentiation, and mineralization. NIH Public Access

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Section: Introductionmentioning

confidence: 99%

Mechanical properties and osteocompatibility of novel biodegradable alanine based polyphosphazenes: Side group effects

et al. 2010

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“…These polymers are quite well known and are the most widely studied inorganic functional polymers containing nitrogen and phosphorus atoms with a variety of organic substitutents attached to phosphorus. POPs are the useful polymeric matrices in controlled release (CR) applications as well as biomaterials [3][4][5][6][7][8]. This is partly due to the ability of hydrophobic segments that degrade slowly in aqueous solutions, making them useful materials in the CR of bioactive molecules.…”

Section: Introductionmentioning

confidence: 99%

“…Allcock et al [10,11] have reported that amino-substituted polyphosphazenes are susceptible to hydrolytic degradation and hence, they hold good promise as biodegradable matrices. Hitherto, a number of hydrophobic and biodegradable polyphosphazenes have been evaluated as CR devices as well as biomaterials [12][13][14][15]. Interest in POPs is mainly attributed to their physico-chemical properties that are dictated depending upon the nature of the substituents attached to the phosphorus atom.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of novel polyorganophosphazenes substituted with 4-methoxybenzylamine and 4-methoxyphenethylamine for in vitro release of indomethacin and 5-fluorouracil

Gudasi

Vadavi

Shelke

et al. 2006

Reactive and Functional Polymers

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“…To gain a better initial insight into the synthetic pathways, attempts were first made to prepare model singlesubstituent and mixed-substituent cyclic trimer derivatives (15)(16)(17)(18)(19)(20)(21) listed in Chart 2.…”

Section: Introductionmentioning

confidence: 99%

Functionalized Polyphosphazenes: Polymers with Pendent Tertiary Trialkylamino Groups

et al. 1998

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Attempts have been made to synthesize polyphosphazenes with pendent tertiary amino side units via macromolecular substitution. Incorporation of -OCH2CH2N(CH3)2, -OCH2CH2OCH2-CH2N(CH3)2, and -NHCH2CH2N(CH3)2 groups was studied. Polymers in which all the side groups consisted of one type of aliphatic tertiary amino-containing unit and species that also contained 2,2,2-trifluoroethoxy or phenoxy groups as cosubstituents were examined. Related phosphazene cyclic trimers were also prepared as small molecule model systems to examine synthetic variables, characterization techniques, and hydrolytic behavior. Those phosphazenes in which the tertiary amino-containing side groups are linked to the skeleton through an aliphatic oxygen-phosphorus bond are sensitive to hydrolysis induced by the basicity of the terminal amino group. However, species in which the tertiary aminocontaining units are linked to the backbone through an alkyl nitrogen-phosphorus bond are stable to water and are candidate materials for use in a range of membrane and surface applications. Small molecule model studies also identified reactions of P-Cl bonds in (NPCl2)3 with N,N-dimethylbutylamine to form dialkylamino-substituted phosphazenes and hydrolysis products.

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Poly(organophosphazenes) with oligopeptides as side groups: prospective biomaterials

Cited by 41 publications

References 8 publications

Mechanical properties and osteocompatibility of novel biodegradable alanine based polyphosphazenes: Side group effects

Mechanical properties and osteocompatibility of novel biodegradable alanine based polyphosphazenes: Side group effects

Synthesis and characterization of novel polyorganophosphazenes substituted with 4-methoxybenzylamine and 4-methoxyphenethylamine for in vitro release of indomethacin and 5-fluorouracil

Functionalized Polyphosphazenes: Polymers with Pendent Tertiary Trialkylamino Groups

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