Poly (methacrylic acid–ethylene glycol dimethacrylate) monolithic capillary for in-tube solid phase microextraction coupled to high performance liquid chromatography and its application to determination of basic drugs in human serum

Yi, Fan; Feng, Yu‐Qi; Da, Shi‐Lu; Shi, Zhi‐Guo

doi:10.1016/j.aca.2004.07.052

Cited by 162 publications

(116 citation statements)

References 24 publications

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“…was a little more complex. Before filling the pre-polymerization mixture into it, the capillary was required to first derivatize with 3-(triethoxysilyl)propyl methacrylate [44] and then dried with N 2 . The following procedure was the same as the above description.…”

Section: Preparation Of Poly(aa-vp-bis) Monolithic Extraction Columnmentioning

confidence: 99%

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Analysis of estrogens in environmental waters using polymer monolith in-polyether ether ketone tube solid-phase microextraction combined with high-performance liquid chromatography

Zhou

et al. 2006

Journal of Chromatography A

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123

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Section: Preparation Of Poly(aa-vp-bis) Monolithic Extraction Columnmentioning

confidence: 99%

“…Because the in-tube SPME-HPLC system used in this study and its operation procedures have been described in detail in the previous papers [44][45][46], they will not be discussed here. The whole system consists of a pre-extraction segment and an analytical segment.…”

Section: Instrumentation and Analytical Conditionsmentioning

confidence: 99%

Analysis of estrogens in environmental waters using polymer monolith in-polyether ether ketone tube solid-phase microextraction combined with high-performance liquid chromatography

Zhou

et al. 2006

Journal of Chromatography A

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123

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“…Thus, the SPME fiber coatings with such properties are definitely in demand; the efforts in this field should be further strengthened. The research on monolith materials is a hot topic in analytical chemistry in recent years, but their application in the SPME field is very limited (101,102). However, we believe that the SPME fiber coatings based on monolith materials should have a bright future because of their unique properties, such as very rapid extraction kinetics, high extraction effect, and good compatibility with biological samples.…”

Section: Resultsmentioning

confidence: 99%

Progress of Solid‐Phase Microextraction Coatings and Coating Techniques

et al. 2006

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(SPME) has been popular as an environmentally friendly sample pretreatment technique to extract a very wide range of analytes. This is partly owing to the development of SPME coatings. One of the key factors affecting the extraction performances, such as the sensitivity, selectivity, and reproducibility, is the properties of the coatings on SPME fibers. This paper classifies the materials used as SPME coatings and introduces some common preparation techniques of SPME coating in detail, such as sol-gel technique, electrochemical polymerization technique, particle direct pasting technique, restricted access matrix SPME technique, and molecularly imprinted SPME technique. IntroductionSolid-phase microextraction (SPME) is a sample preparation technique developed by Pawliszyn et al. (1,2). The process of SPME includes two major operation steps: extraction and desorption. Because both extraction and desorption take place on the coatings, the properties of the coatings determine the performance of SPME. Based on this fact, the development of new coatings has been in great demand for a long time. In recent years, the quantity of papers discussing new coatings for SPME has increased rapidly. In this paper, many of the present coatings are classified, and the common preparation techniques are described in detail. Discussion The classifying of coatingsIn the book Applications of Solid-Phase Microextraction, Górecki (3) sorted the coatings from Supelco (Bellefonte, PA) into two different categories: high-viscosity liquid coatings and solid coatings. He also described the extraction mechanism for both kinds of coatings, respectively. For liquid coatings, the extraction of analytes is obtained by the absorption, in which the analytes can transfer from the surface of coatings to the inside. This kind of coating includes the common stationary phases polydimethylsiloxane (PDMS) and polyacrylate (PA). For solid coatings, the extraction of analytes is based on adsorption, in which the analytes may only stay on the surface of the coatings. Some composite coatings such as PDMS-divinylbenzene (DVB), carbowax-DVB, carbowax-templete resin, etc. from Supelco are solid coatings with porous surfaces. They can only extract analytes by adsorption. During the extraction process, the mechanism of adsorption is much more complex than absorption.With the development of the SPME technique, more and more new materials are utilized in the preparation of coatings. More than half of currently available coatings are solid coatings. However, they are divided by the properties of the materials; the solid coatings are multifarious. Based on organic and inorganic types, there are two primary kinds of coatings: organic and inorganic. Organic coatingOrganic polymer materials are the first kind of material used as SPME coatings. Because traditional SPME fibers utilize fusedsilica fiber as solid-phase carriers, compared with inorganic materials, organic polymer materials are easier to affix with fiber. In addition, at high temperature, the thermal coefficien...

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“…The poly(MAA-co-EDMA) column was prepared as reported by Fan et al 24 The blank urine sample was collected and preprocessed as reported by Zheng et al 25 The preprocessed blank urine sample was directly spiked with CLB and diluted two times with 20 mM phosphate buffer (pH = 7.0) to get the final CLB concentrations of 50, 150 and 250 μg/L.…”

Section: Preparations Of Spe Column and Urine Samplesmentioning

confidence: 99%

“…As a result, we deemed the acceptable sample flow rate should be lower than 45 μL/min. As the effluent flow rates are typically in the range of 3.3 -40 μL/min in the SPE using the capillary columns, 15,24,26,27 the acceptable flow rate of 45 μL/min is sufficient for the coupling between the microcolumn SPE and CE in practice.…”

Section: Operation Parameters Of the μ-Tfgimentioning

confidence: 99%

A Miniaturized Transverse Flow Gating Interface for the On-line Coupling of Solid-phase Extraction with Capillary Electrophoresis

Weng

et al. 2014

ANAL. SCI.

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A miniaturized transverse flow gating interface (μ-TFGI) is presented for the on-line coupling of solid-phase extraction with capillary electrophoresis (SPE-CE). The fabrication and operation procedures of the μ-TFGI are described in detail. After the operation conditions were investigated and selected, the μ-TFGI was evaluated on an SPE-CE-UV setup using clenbuterol (CLB) as the test analyte. The preconcentration factors obtained with the SPE-CE-UV system and the SPE-UV part were 600 and 620, respectively. The plate numbers obtained within 3 min were 100000 and 80000 for automatic injection via the μ-TFGI and manual direct injection, respectively. The precisions were 2.4 -6.8% (RSD, %, n = 9) and 3.1% (RSD, %, n = 27) for the recovery (94.3 -101.9%) and migration time of CLB spiked in urine samples, respectively. These results demonstrate that the μ-TFGI has the ability to exactly and reproducibly transfer nanoliters of fractions from SPE onto CE with no degradation of the efficiencies of SPE and CE.

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Poly (methacrylic acid–ethylene glycol dimethacrylate) monolithic capillary for in-tube solid phase microextraction coupled to high performance liquid chromatography and its application to determination of basic drugs in human serum

Cited by 162 publications

References 24 publications

Analysis of estrogens in environmental waters using polymer monolith in-polyether ether ketone tube solid-phase microextraction combined with high-performance liquid chromatography

Analysis of estrogens in environmental waters using polymer monolith in-polyether ether ketone tube solid-phase microextraction combined with high-performance liquid chromatography

Progress of Solid‐Phase Microextraction Coatings and Coating Techniques

A Miniaturized Transverse Flow Gating Interface for the On-line Coupling of Solid-phase Extraction with Capillary Electrophoresis

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