Poly(meth)acrylate-based coatings

Nollenberger, Kathrin; Albers, Jessica

doi:10.1016/j.ijpharm.2013.09.029

Cited by 90 publications

(51 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Understanding the mechanisms behind the film formation is critical for selecting the appropriate coating excipients. Minimum film forming temperature (MFT) and glass transition temperature (Tg) are key parameters for the efficient film formation from aqueous dispersions (Nollenberger & Albers, 2013). In the work, TEC was used as plasticizers to lower MFT.…”

Section: Preparation Of Emz-mrpsmentioning

confidence: 99%

“…ERS (slightly permeable) and ERL (highly permeable) are poly(meth)acrylates, which can be mixed at any ratio in aqueous form to adjust permeability and obtain specific release patterns, as a result, it is commonly used for SR film coatings. After contacting with gastrointestinal fluids, the film coatings swell, independent of pH and release the active by a diffusion-controlled mechanism (Nollenberger & Albers, 2013).…”

Section: Subjectmentioning

confidence: 99%

“…As the growing concerns of the environment, safety and cost, pharmaceutical manufacturing has been moving from organic forms to aqueous coating systems, e.g. aqueous polymer dispersions were developed and marketed-drived to substitute organic coating solutions (Nollenberger and Albers, 2013). Eudragit Õ , including a series Poly(meth)acrylates, which is well known and widely used in the pharmaceutical industry allows the active ingredients of solid dosage form to perform during the passage of the human body.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preparation and in vitro/in vivo evaluation of esomeprazole magnesium-modified release pellets

et al. 2014

View full text Add to dashboard Cite

To reduce the drug plasma concentration fluctuation without being destroyed by gastric fluid, novel Esomeprazole magnesium modified-release pellets (EMZ-MRPs) with suitable in vitro release profiles and good in vitro and in vivo correlation (IVIVC) were developed. Fluid-bed was used to obtain EMZ-loaded pellets by spraying drug suspension onto blank sugar pellets. The drug-loaded pellets were subsequently coated with Eudragit Õ RS30D/RL30D (ERS/ERL) aqueous dispersion to achieve sustained-release (SR) characteristics. Furthermore, the SR pellets were coated with Eudragit Õ L30D-55 (EL-55) aqueous dispersion to achieve enteric properties. Besides, isolated coating film was necessary between drug layer and SR layer, as well as SR and enteric-coated layer to protect from their possible reaction. The resulting pellets were filled into the hard gelatin capsules for in vitro release processing and single-dose pharmacokinetic study in rats. The optimal formulation achieved good SR feature both in vitro and in vivo with a relative bioavailability of 103.50%. A good IVIVC was characterized by a high coefficient of determination (r ¼ 0.9945) by deconvolution method. Compared to those of EMZ entericcoated pellets (EMZ-ECPs, trade name NEXIUM), the in vivo study make known that the EMZ-MRPs with decreased maximum plasma concentration (C max ), prolonged peak concentration time (T max ) and mean residence time (MRT), and similar values both area under concentration-time curve from 0 to t (AUC 0-t ) and 0 to infinity (AUC 0-1 ). Collectively, these results manifested EMZ-MRPs had a satisfactory sustained-release behavior, a desired pharmacokinetic property, improved in vivo retention and decreased plasma drug concentration fluctuation.

show abstract

Section: Preparation Of Emz-mrpsmentioning

confidence: 99%

Section: Subjectmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation and in vitro/in vivo evaluation of esomeprazole magnesium-modified release pellets

et al. 2014

View full text Add to dashboard Cite

show abstract

“…So, antiadherents are added to the coating formulation. Most frequently, talc is used to decrease tackiness and is recommended for use with acrylic polymers (13). However, the addition of talc in coating formulations can result in sedimentation of the material during the spraying process, clogging of the spray nozzle, and incompatibilities with other materials in the coating and/or the substrate (14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Effect of Antiadherents on the Physical and Drug Release Properties of Acrylic Polymeric Films

et al. 2015

View full text Add to dashboard Cite

Abstract. Antiadherents are used to decrease tackiness of a polymer coating during both processing and subsequent storage. Despite being a common excipient in coating formulae, antiadherents may affect mechanical properties of the coating film as well as drug release from film-coated tablets, but how could addition of antiadherents affect these properties and to what extent and is there a relation between the physical characteristics of the tablet coat and the drug release mechanisms? The aim of this study was to evaluate physical characteristics of films containing different amounts of the antiadherents talc, glyceryl monostearate, and PlasACRYL TM T20. Eudragit RL30D and Eudragit RS30D as sustained release polymers and Eudragit FS30D as a delayed release material were used. Polymer films were characterized by tensile testing, differential scanning calorimetry (DSC), microscopic examination, and water content as calculated from loss on drying. The effect of antiadherents on in vitro drug release for the model acetylsalicylic acid tablets coated with Eudragit FS30D was also determined. Increasing talc concentration was found to decrease the ability of the polymer films to resist mechanical stress. In contrast, glyceryl monostearate (GMS) and PlasACRYL produced more elastic films. Talc at concentrations higher than 25% caused negative effects, which make 25% concentration recommended to be used with acrylic polymers. All antiadherents delayed the drug release at all coating levels; hence, different tailoring of drug release may be achieved by adjusting antiadherent concentration with coating level.

show abstract

“…The film formers in use today are polymers: polymethacrylates, cellulose-based polymers, polyvinyl derivativ and other copolymers [40,41]. The polymer layer is soluble (pH-dependent or pH-independent dissolution) or becomes permeable.…”

Section: Film Coatingsmentioning

confidence: 99%

Development and characterization of modified-release oral preparations containing riboflavin

Buchholcz

View full text Add to dashboard Cite

Poly(meth)acrylate-based coatings

Cited by 90 publications

References 36 publications

Preparation and in vitro/in vivo evaluation of esomeprazole magnesium-modified release pellets

Preparation and in vitro/in vivo evaluation of esomeprazole magnesium-modified release pellets

Effect of Antiadherents on the Physical and Drug Release Properties of Acrylic Polymeric Films

Development and characterization of modified-release oral preparations containing riboflavin

Contact Info

Product

Resources

About