Poly-Lysine Dendritic Nanocarrier to Target Epidermal Growth Factor Receptor Overexpressed Breast Cancer for Methotrexate Delivery

Narayanan, Pratibha; Anitha, A; Ajayakumar, Neethu; Kumar, K. Santhosh

doi:10.3390/ma15030800

Cited by 9 publications

(4 citation statements)

References 29 publications

(24 reference statements)

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“…The efficacy analysis using NOD-SCID mice also demonstrated that the DDS reduced tumor volume. The mice treated with the DDSs developed gained weight faster than those treated with the free drug, which allowed for a conclusion that dendrimer is more tolerated by mice than the free drug [129].…”

Section: Dendritic Polymersmentioning

confidence: 99%

An Overview of Biopolymers for Drug Delivery Applications

Opriș,

Mormile,

Lung

et al. 2024

Applied Sciences

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Nowadays, drug delivery has an important role in medical therapy. The use of biopolymers in developing drug delivery systems (DDSs) is increasingly attracting attention due to their remarkable and numerous advantages, in contrast to conventional polymers. Biopolymers have many advantages (biodegradability, biocompatibility, renewability, affordability, and availability), which are extremely important for developing materials with applications in the biomedical field. Additionally, biopolymers are appropriate when they improve functioning and have a number of positive effects on human life. Therefore, this review presents the most used biopolymers for biomedical applications, especially in drug delivery. In addition, by combining different biopolymers DDSs with tailored functional properties (e.g., physical properties, biodegradability) can be developed. This review summarizes and provides data on the progress of research on biopolymers (chitosan, alginate, starch, cellulose, albumin, silk fibroin, collagen, and gelatin) used in DDSs, their preparation, and mechanism of action.

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Section: Dendritic Polymersmentioning

confidence: 99%

An Overview of Biopolymers for Drug Delivery Applications

Opriș,

Mormile,

Lung

et al. 2024

Applied Sciences

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“…A dendrimer can be built on virtually any form of chemistry, and the nature of that chemistry greatly influences its solubility, degradability, and biological activity [ 159 ]. Polyamidoamines (PAMAM) [ 160 ], poly- l -lysine (PLL) [ 161 ], polyamides (polypeptides) [ 162 ], poly (propylene imine) [ 163 ], and carbohydrates [ 164 ] are some of the most frequently used forms of dendrimers in biological applications. However, PAMAM dendrimers are the most prevalent dendrimer scaffold, commercially available with a wide range of generations and surface properties.…”

Section: Types Of Nanocarriersmentioning

confidence: 99%

A Recent Review on Cancer Nanomedicine

Giri

Banerjee

Layek

2023

Cancers

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Cancer is one of the most prevalent diseases globally and is the second major cause of death in the United States. Despite the continuous efforts to understand tumor mechanisms and various approaches taken for treatment over decades, no significant improvements have been observed in cancer therapy. Lack of tumor specificity, dose-related toxicity, low bioavailability, and lack of stability of chemotherapeutics are major hindrances to cancer treatment. Nanomedicine has drawn the attention of many researchers due to its potential for tumor-specific delivery while minimizing unwanted side effects. The application of these nanoparticles is not limited to just therapeutic uses; some of them have shown to have extremely promising diagnostic potential. In this review, we describe and compare various types of nanoparticles and their role in advancing cancer treatment. We further highlight various nanoformulations currently approved for cancer therapy as well as under different phases of clinical trials. Finally, we discuss the prospect of nanomedicine in cancer management.

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“…MTX was linked to the nanocarrier by using cathepsin B cleavable spacer (glycine-phenylalanine-leucine-glycine (GFLG)). The results showed that MTX released from the nanosystem decreased the percentage of cells in the G2/M phase and enhanced the percentage of cells in the S and G0 phase in both MDA-MB-231 (EGFR overexpressed) and SiHa (EGFR negative) cells (Narayanan et al, 2022).…”

Section: Stimuli-responsive Polymeric Nanoparticlesmentioning

confidence: 99%

Nanocarriers for methotrexate delivery/codelivery in the frame of cancer diagnostics and treatment: a review

Mukhtar,

Ezra Manicum,

Shojaei Barjouei

et al. 2023

Front. Biomater. Sci.

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Cancer is one of the most life-threatening family of diseases that cause death worldwide. As a highly researched and successful therapeutic agent, methotrexate (MTX) treats many solid tumours, hematologic malignancies, and autoimmune illnesses. Despite many benefits, methotrexate induces drug resistance and limits plasma half-life due to its poor pharmacokinetics. The variable biological availability have prompted researchers to investigate innovative delivery strategies for enhancing its therapeutic qualities. To develop more suitable methotrexate formulations, nanoparticles (NPs) have recently gained a significant interest. A wide range of nanoparticles, including polymer-based nanoparticles, carbon-based nanoparticles, lipid-based nanoparticles, as well as inorganic nanoparticles, can be deliver cancer chemotherapeutics such as methotrexate. Loading methotrexate into NPs can provide a delivery system that has shown great promise to carcinoma therapy. In this review, we will describe the feasibility of NP-based strategies to deliver methotrexate in cancer therapy, outlining the current state of the art and the challenges/promises for the future.

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Poly-Lysine Dendritic Nanocarrier to Target Epidermal Growth Factor Receptor Overexpressed Breast Cancer for Methotrexate Delivery

Cited by 9 publications

References 29 publications

An Overview of Biopolymers for Drug Delivery Applications

An Overview of Biopolymers for Drug Delivery Applications

A Recent Review on Cancer Nanomedicine

Nanocarriers for methotrexate delivery/codelivery in the frame of cancer diagnostics and treatment: a review

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