Poly (lactide -co- glycolide) Fiber: An Overview

Azimi, Bahareh; Nourpanah, Parviz; Rabiee, Mohammad; Arbab, Shahram

doi:10.1177/155892501400900107

Cited by 28 publications

(31 citation statements)

References 104 publications

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“…In addition, both micro- and macroscale visualization and a lack of adhesion to the mandrel, resulted when the PLGA and PLCL polymers were electrospun in HFIP. This is in agreement with other work using PLGA, where PLGA concentration and flow rate, as related to inherent viscosity, is known to significantly impact fiber diameter [79, 80]. …”

Section: Discussionsupporting

confidence: 92%

“…In addition to swelling and matrix degradation, polymer crystallinity is also a primary factor affecting the degradation of different polymers. For a PLGA co-polymer, polymer chains in the amorphous regions initially degrade via hydrolysis and during this phase little sample mass is lost [79]. Correspondingly, as molecular weight decreases [79], there is an increase in solubility, mass loss, water uptake, and hydrophilicity.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of poly(lactic-co-glycolic acid) and poly( dl -lactide-co-ε-caprolactone) electrospun fibers for the treatment of HSV-2 infection

Aniagyei

Sims

Malik

et al. 2017

Materials Science and Engineering: C

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More diverse multipurpose prevention technologies are urgently needed to provide localized, topical pre-exposure prophylaxis against sexually transmitted infections (STIs). In this work, we established the foundation for a multipurpose platform, in the form of polymeric electrospun fibers (EFs), to physicochemically treat herpes simplex virus 2 (HSV-2) infection. To initiate this study, we fabricated different formulations of poly(lactic-co-glycolic acid) (PLGA) and poly(DL-lactide-co-ε-caprolactone) (PLCL) EFs that encapsulate Acyclovir (ACV), to treat HSV-2 infection in vitro. Our goals were to assess the release and efficacy differences provided by these two different biodegradable polymers, and to determine how differing concentrations of ACV affected fiber efficacy against HSV-2 infection and the safety of each platform in vitro. Each formulation of PLGA and PLCL EFs exhibited high encapsulation efficiency of ACV, sustained-delivery of ACV through one month, and in vitro biocompatibility at the highest doses of EFs tested. Additionally, all EF formulations provided complete and efficacious protection against HSV-2 infection in vitro, regardless of the timeframe of collected fiber eluates tested. This work demonstrates the potential for PLGA and PLCL EFs as delivery platforms against HSV-2, and indicates that these delivery vehicles may be expanded upon to provide protection against other sexually transmitted infections.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Evaluation of poly(lactic-co-glycolic acid) and poly( dl -lactide-co-ε-caprolactone) electrospun fibers for the treatment of HSV-2 infection

Aniagyei

Sims

Malik

et al. 2017

Materials Science and Engineering: C

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“…They are mainly used in the pharmaceutical industry to develop drug delivery systems, as a sutures for wound closure and as scaffolding materials for tissue engineering [43]. …”

Section: Fabrication Of Synthetic Biopolymersmentioning

confidence: 99%

Fabrication of Porous Materials from Natural/Synthetic Biopolymers and Their Composites

et al. 2016

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Biopolymers and their applications have been widely studied in recent years. Replacing the oil based polymer materials with biopolymers in a sustainable manner might give not only a competitive advantage but, in addition, they possess unique properties which cannot be emulated by conventional polymers. This review covers the fabrication of porous materials from natural biopolymers (cellulose, chitosan, collagen), synthetic biopolymers (poly(lactic acid), poly(lactic-co-glycolic acid)) and their composite materials. Properties of biopolymers strongly depend on the polymer structure and are of great importance when fabricating the polymer into intended applications. Biopolymers find a large spectrum of application in the medical field. Other fields such as packaging, technical, environmental, agricultural and food are also gaining importance. The introduction of porosity into a biomaterial broadens the scope of applications. There are many techniques used to fabricate porous polymers. Fabrication methods, including the basic and conventional techniques to the more recent ones, are reviewed. Advantages and limitations of each method are discussed in detail. Special emphasis is placed on the pore characteristics of biomaterials used for various applications. This review can aid in furthering our understanding of the fabrication methods and about controlling the porosity and microarchitecture of porous biopolymer materials.

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“…Table 1 shows estimations of the two characteristic kinetic parameters describing the typical erosion profile, onset time (ton) and observed pseudo-first-order rate of erosion constant (ke). The latter was characterized as a slope value according to the equation [41] ln(D t ) = A -k e t…”

Section: Mass Loss Kineticsmentioning

confidence: 99%

Investigation of the Influence of PLA Molecular and Supramolecular Structure on the Kinetics of Thermal-Supported Hydrolytic Degradation of Wet Spinning Fibres

Giełdowska¹,

Puchalski²,

Szparaga³

et al. 2020

Preprint

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In this study, differences in the kinetics of thermal-supported hydrolytic degradation of poly(lactic acid) (PLA) sample wet spinning fibres due to material variance in the initial molecular and supramolecular structure were analysed. The investigation was carried out at the microstructural and molecular levels by using readily available methods such as scanning electron microscopy, mass erosion measurement and estimation of intrinsic viscosity. The results show a varying degree of influence of the initial structure on the degradation rate of studied PLA fibres. The experiment shows that hydrolytic degradation at a temperature close to the cold crystallization temperature on a macroscopic level is definitely more rapid for the amorphous material, while on a molecular scale it is similar to a semi-crystalline material. Further, for the adopted degradation temperature of 90 °C, a marginal influence of pH of the degradation medium on the degradation kinetics was also demonstrated

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Poly (lactide -co- glycolide) Fiber: An Overview

Cited by 28 publications

References 104 publications

Evaluation of poly(lactic-co-glycolic acid) and poly( dl -lactide-co-ε-caprolactone) electrospun fibers for the treatment of HSV-2 infection

Evaluation of poly(lactic-co-glycolic acid) and poly( dl -lactide-co-ε-caprolactone) electrospun fibers for the treatment of HSV-2 infection

Fabrication of Porous Materials from Natural/Synthetic Biopolymers and Their Composites

Investigation of the Influence of PLA Molecular and Supramolecular Structure on the Kinetics of Thermal-Supported Hydrolytic Degradation of Wet Spinning Fibres

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