Poly(lactic acid)/TiO2 nanocomposites as alternative biocidal and antifungal materials

Fonseca, C.; Ochoa, A.; Ulloa, María Teresa; Álvarez, Enrique José Varela; Canales, Daniel; Zapata, Paula Andrea

doi:10.1016/j.msec.2015.07.069

Cited by 104 publications

(86 citation statements)

References 48 publications

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“…Figure A shows that the addition of 1 wt% TiO 2 nanoparticles results in a notable reduction in the viscosity values especially at low shear rate zone. This result could be attributed to the lubricating role of nanoparticles at very low contents which has been previously reported . Further addition of TiO 2 to 3 wt% caused the viscosity curve to be shifted to higher values, and a stronger shear‐thinning behavior was detected.…”

Section: Resultssupporting

confidence: 75%

“…Once immobilized within the polymer matrix, a substantial enhancement in polymer degradability under solar or UV irradiation could be attained . TiO 2 nanoparticles were also suggested as promising nucleating agents and shown to greatly increase the crystallization kinetics of PLA . Buzarovska and Grozdanov have demonstrated that the degree of crystallinity of PLA can be significantly increased with up to 5 wt% of TiO 2 , which was attributed to their nucleating role.…”

Section: Introductionmentioning

confidence: 99%

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Effect of nanoparticle type and content on morphology, rheology, and crystallinity of poly(lactic acid) using titanium dioxide and polyhedral oligomeric silsesquioxane nanoparticles

et al. 2019

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In this study, under the same conditions, two different nanoparticles, namely, titanium dioxide (TiO2) and polyhedral oligomeric silsesquioxane (POSS) were added to the poly(lactic acid) (PLA) matrix via the solution casting technique. Morphological analysis showed that POSS had a better distribution within the PLA matrix. However, rheological analysis revealed the stronger influence of TiO2 on shear viscosity values, and a more notable viscosity upturn at moderate to high inclusions of TiO2 within the low shear rate zone. On the other hand, POSS was found to act as a lubricant even at a content of 3 wt% which was attributed to the very small dimensions of POSS. Such lubricating role, found from rheology, caused a boost in the crystallinity of PLA based on differential scanning calorimetry results. Moreover, it was found that TiO2 had an adverse effect on the crystallinity of PLA which was ascribed to the hindered motions of PLA chains upon addition of moderate to high inclusions of TiO2. The results of this study emphasize the crucial role of nanoparticle type and content on the properties of PLA.

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Section: Resultssupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Effect of nanoparticle type and content on morphology, rheology, and crystallinity of poly(lactic acid) using titanium dioxide and polyhedral oligomeric silsesquioxane nanoparticles

et al. 2019

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“…Modifications and synthesis of Poly(lactic acid) (PLA), Poly(glycolic acid) (PGA), and their copolymer ratios are widely used in medicine ranging from structural cardiovascular applications to drug delivery . Recent advancements in photochemical crosslinking of Poly(propylene fumarate) (PPF) have been developed for orthopedic and oncological applications …”

Section: Discussionmentioning

confidence: 99%

“…[23][24][25] Recent advancements in photochemical crosslinking of Poly(propylene fumarate) (PPF) have been developed for orthopedic and oncological applications. 26,27 Using the same technique of initiator substitution, ciprofloxacin, was investigated as a possible initiator with therapeutic potential. Ciprofloxacin has a lower molecular weight than gadodiamide, but contains halogen fluorine.…”

Section: Discussionmentioning

confidence: 99%

Bacterial sensitivity assessment of multifunctional polymeric coatings for airway stents

Goodfriend

Welch²,

Thomas³

et al. 2016

J. Biomed. Mater. Res.

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Current interventional technology for pediatric airway obstruction consists of cardiovascular stents and silicon tubes. These devices are composed of permanent materials that have limitations in biocompatibility and mechanical properties that make them controversial for used in pediatrics. Bioresorbable stents offer a temporary intervention that dissolves in the body over time and can serve as a platform for local drug delivery. Here we investigate a novel approach to use an antibiotic, ciprofloxacin, as a polymerization initiator to synthesize poly(ciprofloxacin fumaric acid) (PCFA) and then a second polymer using gadodiamide as an initiator to synthesize poly(gadodiamide ciprofloxacin fumaric acid) (PGCFA). Polymer structure, degradation, thermal properties, and rheological behavior were analyzed. Ciprofloxacin released was determined and polymer degradation extracts were used in bacterial sensitivity assessments with four common airway pathogens. PCFA and PGCFA polymers and drug release properties were compared to our previously published polymer poly(fumaric acid) (PFA). These novel polymers enable new possibilities as coatings for bioresorbable biomedical applications that require antibiotic resistance and imaging capabilities. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2153-2161, 2017.

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“…Fonseca et al produced PLA/TiO 2 nanocomposite by a melting process that showcased an increased biocidal and antifungal characteristic under UV irradiation . The nanocomposite shows a reduction of Escherichia coli and Aspergillus fumigatus of 94.3% and 99.9%, respectively.…”

Section: Reinforcing Pla‐based Materials Through Nanocompositesmentioning

confidence: 99%

Poly(lactic acid)‐based nanocomposites

Basu

Nazarkovsky

Ghadi

et al. 2016

Polymers for Advanced Techs

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Classic plastics accumulate in nature causing environmental pollution, yet as a counterbalance they benefit society in many ways. They are versatile, cost‐effective, and can be tailored to have desired properties. The global environment has led to the fabrication of commodity plastics from environmentally degradable polymers. Poly(lactic acid) (PLA) is the most promising among the environmentally friendly polymers available. PLA‐based plastics have mechanical, thermal, and transparency similar to traditional plastics, and they can be molded and fabricated using the same equipment and procedures. Their material properties are enhanced through nanocomposites, compatibilizers, plasticizers, and other fillers (flame retardant, ultraviolet filter, etc.). This review summarizes mass production techniques and property reinforcements (focusing on nanocomposites and plasticizers) for PLA‐based plastics for commodity use. Copyright © 2016 John Wiley & Sons, Ltd.

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Poly(lactic acid)/TiO2 nanocomposites as alternative biocidal and antifungal materials

Cited by 104 publications

References 48 publications

Effect of nanoparticle type and content on morphology, rheology, and crystallinity of poly(lactic acid) using titanium dioxide and polyhedral oligomeric silsesquioxane nanoparticles

Effect of nanoparticle type and content on morphology, rheology, and crystallinity of poly(lactic acid) using titanium dioxide and polyhedral oligomeric silsesquioxane nanoparticles

Bacterial sensitivity assessment of multifunctional polymeric coatings for airway stents

Poly(lactic acid)‐based nanocomposites

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