Poly(lactic acid) for delivery of bioactive macromolecules

James, Roshan; Manoukian, Ohan S.; Kumbar, Sangamesh G.

doi:10.1016/j.addr.2016.06.009

Cited by 51 publications

(21 citation statements)

References 110 publications

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“…Therapeutic macromolecules (such as peptides and genes) are being actively developed as alternative to traditional chemotherapeutic drugs, which show widely observed serious side effects and poor patient compliance [133–135]. Yu et al designed pH-responsive polymeric micelles that were mannosylated using “click” chemistry to achieve CD206 (mannose receptor)-targeted delivery siRNA to TAMs.…”

Section: Nanomedicines Targeting Dysfunctional Macrophage-associatmentioning

confidence: 99%

Nanomedicines for dysfunctional macrophage-associated diseases

Ghosh

Yang

2017

Journal of Controlled Release

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Macrophages play vital functions in host inflammatory reaction, tissue repair, homeostasis and immunity. Dysfunctional macrophages have significant pathophysiological impacts on diseases such as cancer, inflammatory diseases (rheumatoid arthritis and inflammatory bowel disease), metabolic diseases (atherosclerosis, diabetes and obesity) and major infections like human immunodeficiency virus. In view of this common etiology in these diseases, targeting the recruitment, activation and regulation of dysfunctional macrophages represents a promising therapeutic strategy. With the advancement of nanotechnology, development of nanomedicines to efficiently target dysfunctional macrophages can strengthen the effectiveness of therapeutics and improve clinical outcomes. This review discusses the specific roles of dysfunctional macrophages in various diseases and summarizes the latest advances in nanomedicine-based therapeutics and theranostics for treating diseases associated with dysfunctional macrophages.

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Section: Nanomedicines Targeting Dysfunctional Macrophage-associatmentioning

confidence: 99%

Nanomedicines for dysfunctional macrophage-associated diseases

Ghosh

Yang

2017

Journal of Controlled Release

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“…Because it is biocompatible and biodegradable, it has become a material of choice in biomedical applications [14][15][16]. This also includes the use of PLA for long-term controlled release of active ingredients [17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

Wongkanya

Teeranachaideekul

Makarasen

et al. 2020

Mater. Res. Express

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A controlled release system of Plai (Zingiber cassumunar Roxb.) oil based on electrospun poly(lactic) acid (PLA) nanofiber mat was successfully developed. The physicochemical properties of the nanofibers loaded with select amounts of oil (15%, 20%, and 30% wt) were characterized using various techniques, including a morphological study using scanning electron microscopy (SEM), structural determination using Fourier transform infrared spectrometry (FTIR) and x-ray diffraction (XRD), as well as thermal properties study using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The loading content and the entrapment efficiency of Plai oil within the fiber mats were evaluated and were found to be remarkably high, ensuring that PLA was an appropriate material for Plai oil loading. The ability of the nanofiber mats to release (E)-1-(3,4dimethoxyphenyl) butadiene (DMPBD) was also examined and the fiber mats showed controlled release characteristics. As the nanofiber mats have particularly high specific surface area with fully accessible and interconnected pore structures, a liquid medium with active ingredients will not be trapped in blind pores but can be fully released out of the fiber matrix. Furthermore, in vitro skin permeation of the active compound as well as a skin irritation were assessed using reconstructed human epidermis (EpiSkin TM ). It was found that DMPBD could efficiently penetrate through the skin model. Moreover, the nanofiber mats containing Plai oil also showed no skin irritation, indicating them as promising prototypes for medical applications.

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“…demonstrated that primary articular chondrocytes can be cultured in vitro on extrusion‐printed Acrylonitrile butadiene styrene and poly(lactic acid) (PLA) scaffolds with 700 µm pore size . PLA has a long history of tissue engineering, regenerative medicine, and drug delivery applications as an FDA approved biocompatible and degradable biopolymer . Scaffolds were developed in the shape of intervertebral discs.…”

Section: D Printing Proceduresmentioning

confidence: 99%

Polymeric 3D printed structures for soft‐tissue engineering

Stratton

Manoukian

Patel

et al. 2017

J of Applied Polymer Sci

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Three-dimensional (3D) printing, or rapid prototyping, is a fabrication technique that is used for various engineering applications with advantages such as mass production and fine tuning of spatial-dimensional properties. Recently, this fabrication method has been adopted for tissue engineering applications due to its ability to finely tune porosity and create precise, uniform, and repeatable structures. This review aims to introduce 3D printing applications in soft-tissue engineering and regenerative medicine including state-of-the-art scaffolds and key future challenges. Furthermore, 3D printing of individual cells, an evolution of traditional 3D printing technology which represents a cutting-edge technique for the creation of cell seeded scaffolds in vitro, is discussed. Key advances demonstrate the advantages of 3D printing, while also highlighting potential shortcomings to improve upon. It is clear that as 3D printing technology continues to develop, it will serve as a truly revolutionary means for fabrication of structures and materials for regenerative applications.

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Poly(lactic acid) for delivery of bioactive macromolecules

Cited by 51 publications

References 110 publications

Nanomedicines for dysfunctional macrophage-associated diseases

Nanomedicines for dysfunctional macrophage-associated diseases

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

Polymeric 3D printed structures for soft‐tissue engineering

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