Poly-L-ornithine blocks the inhibitory effects of fibronectin on oligodendrocyte differentiation and promotes myelin repair

Ping, Jie; Fu, Hui; Xiong, Yajie; Soomro, ShahidHussain; Huang, Zhonghai

doi:10.4103/1673-5374.353493

Cited by 4 publications

(2 citation statements)

References 84 publications

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“…SCI leads to axonal demyelination. The normal myelin sheath is crucial for the conduction of nerve impulses in the nervous system. , LFB staining was performed to analyze axonal demyelination and evaluate the degree of damage to myelin sheaths at the lesion site. Compared with mice in the injury group, those in the Zn@MOF and Zn@MOF-TPD treatment groups exhibited better preservation of myelin sheaths as evidenced by a reduction in the formation of cystic cavities and gray matter in the epicenter of the lesion (Figure C).…”

Section: Resultsmentioning

confidence: 99%

Engineered Multifunctional Zinc–Organic Framework-Based Aggregation-Induced Emission Nanozyme for Accelerating Spinal Cord Injury Recovery

Zheng,

Chen,

Wang

et al. 2024

ACS Nano

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Functional recovery following a spinal cord injury (SCI) is challenging. Traditional drug therapies focus on the suppression of immune responses; however, strategies for alleviating oxidative stress are lacking. Herein, we developed the zinc−organic framework (Zn@MOF)-based aggregationinduced emission−active nanozymes for accelerating recovery following SCI. A multifunctional Zn@MOF was modified with the aggregation-induced emission−active molecule 2-(4-azidobutyl)-6-(phenyl(4-(1,2,2-triphenylvinyl)phenyl)amino)-1Hphenalene-1,3-dione via a bioorthogonal reaction, and the resulting nanozymes were denoted as Zn@MOF-TPD. These nanozymes gradually released gallic acid and zinc ions (Zn 2+ ) at the SCI site. The released gallic acid, a scavenger of reactive oxygen species (ROS), promoted antioxidation and alleviated inflammation, re-establishing the balance between ROS production and the antioxidant defense system. The released Zn 2+ ions inhibited the activity of matrix metalloproteinase 9 (MMP-9) to facilitate the regeneration of neurons via the ROS-mediated NF-κB pathway following secondary SCI. In addition, Zn@MOF-TPD protected neurons and myelin sheaths against trauma, inhibited glial scar formation, and promoted the proliferation and differentiation of neural stem cells, thereby facilitating the repair of neurons and injured spinal cord tissue and promoting functional recovery in rats with contusive SCI. Altogether, this study suggests that Zn@MOF-TPD nanozymes possess a potential for alleviating oxidative stress-mediated pathophysiological damage and promoting motor recovery following SCI.

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Section: Resultsmentioning

confidence: 99%

Engineered Multifunctional Zinc–Organic Framework-Based Aggregation-Induced Emission Nanozyme for Accelerating Spinal Cord Injury Recovery

Zheng,

Chen,

Wang

et al. 2024

ACS Nano

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“…This is of particular importance, since one of the key challenges in NSC therapies is directing the Bioengineering 2023, 10, 1309 2 of 13 differentiation of neural stem cells towards the neuronal lineage. Finally, Ping, Jie et al demonstrated that poly-l-ornithine enhances myelin regeneration and promotes locomotor recovery in an animal model of focal demyelination [24], suggesting that PLO has potential to be part of a regenerative therapeutic strategy for injuries of the central nervous system. Likewise, NH 2 -terminated surfaces have been shown to promote neuronal differentiation of NSCs [20].…”

Section: Introductionmentioning

confidence: 99%

Plant Cellulose as a Substrate for 3D Neural Stem Cell Culture

Couvrette,

Walker,

Bui

et al. 2023

Bioengineering

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Neural stem cell (NSC)-based therapies are at the forefront of regenerative medicine strategies for various neural defects and injuries such as stroke, traumatic brain injury, and spinal cord injury. For several clinical applications, NSC therapies require biocompatible scaffolds to support cell survival and to direct differentiation. Here, we investigate decellularized plant tissue as a novel scaffold for three-dimensional (3D), in vitro culture of NSCs. Plant cellulose scaffolds were shown to support the attachment and proliferation of adult rat hippocampal neural stem cells (NSCs). Further, NSCs differentiated on the cellulose scaffold had significant increases in their expression of neuron-specific beta-III tubulin and glial fibrillary acidic protein compared to 2D culture on a polystyrene plate, indicating that the scaffold may enhance the differentiation of NSCs towards astrocytic and neuronal lineages. Our findings suggest that plant-derived cellulose scaffolds have the potential to be used in neural tissue engineering and can be harnessed to direct the differentiation of NSCs.

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Delivery technologies for therapeutic targeting of fibronectin in autoimmunity and fibrosis applications

Bonadio,

Bashiri,

Halligan

et al. 2024

Advanced Drug Delivery Reviews

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Poly-L-ornithine blocks the inhibitory effects of fibronectin on oligodendrocyte differentiation and promotes myelin repair

Cited by 4 publications

References 84 publications

Engineered Multifunctional Zinc–Organic Framework-Based Aggregation-Induced Emission Nanozyme for Accelerating Spinal Cord Injury Recovery

Engineered Multifunctional Zinc–Organic Framework-Based Aggregation-Induced Emission Nanozyme for Accelerating Spinal Cord Injury Recovery

Plant Cellulose as a Substrate for 3D Neural Stem Cell Culture

Delivery technologies for therapeutic targeting of fibronectin in autoimmunity and fibrosis applications

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