2018
DOI: 10.7498/aps.67.20180456
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Poly-L-lysine induced shape change of negatively charged giant vesicles

Abstract: Decoration of biomembrane with polymer may improve its physical properties, biocompatibility, and stability. In this study, we employ the inverted fluorescence microscopy to characterize the polylysine (PLL) induced shape transformation of the negatively charged giant unilamellar vesicles (GUVs) in low ionic medium. It is found that PLL may be adsorbed to the 1, 2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1, 2-dioleoyl-sn-glycero-3-phosphatidic acid (DOPA) binary mixture vesicles, resulting in the attach… Show more

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“…The MD simulations are widely used to study the interaction of lipid molecules and proteins in the membrane. [29][30][31][32] However, when studying the large scale membrane deformation, MD simulations are computationally too intensive and expensive. In this paper, we adopt the classical Helfrich theory of membrane which is a continuum model and has broad applications in studying the large scale deformation of membrane.…”
Section: Modelmentioning
confidence: 99%
“…The MD simulations are widely used to study the interaction of lipid molecules and proteins in the membrane. [29][30][31][32] However, when studying the large scale membrane deformation, MD simulations are computationally too intensive and expensive. In this paper, we adopt the classical Helfrich theory of membrane which is a continuum model and has broad applications in studying the large scale deformation of membrane.…”
Section: Modelmentioning
confidence: 99%