Poly(l-lactide-co-glycolide) biodegradable microfibers and electrospun nanofibers for nerve tissue engineering: an in vitro study

Bini, T. B.; Gao, Shujun; Wang, Shu; Ramakrishna, Seeram

doi:10.1007/s10853-006-0714-3

Cited by 104 publications

(63 citation statements)

References 20 publications

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“…During the electrospinning process, a strong electrostatic field is applied to a polymer solution and, when the electric forces overcome the surface tension of the solution, a charged jet of solution is ejected towards the collecting material screen, where a continuous stretch of nanofibres is obtained (Zong et al, 2002;Zeng et al, 2003;Yarin et al, 2001). Electrospun nanofibrous scaffolds of PCL, PCL-gelatin, poly(L-lactic acid), PCL-collagen, PCL-chitosan, poly(lactic acid-coglycolic acid) have been used for nerve tissue engineering (Yang et al, 2004;Xu et al, 2004;Bini et al, 2006;Schnell et al, 2007;Yang et al, 2005;Murugan and Ramakrishna, 2007;Lee et al, 2009c). To take advantage of the nanofibrous structures together with the electrical stimulations in tissue engineering, conductive nanofibrous scaffolds were applied for nerve tissue engineering.…”

Section: Electrospun Conductive Polymers For Nerve Tissue Engineeringmentioning

confidence: 99%

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

603

389

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Among the numerous attempts to integrate tissue engineering concepts into strategies to repair nearly all parts of the body, neuronal repair stands out. This is partially due to the complexity of the nervous anatomical system, its functioning and the inefficiency of conventional repair approaches, which are based on single components of either biomaterials or cells alone. Electrical stimulation has been shown to enhance the nerve regeneration process and this consequently makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering. In this review, by taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, we discuss the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering. Other electrospun, composite, conductive scaffolds, such as PANI/gelatin and PPy/poly(ε-caprolactone), with or without electrical stimulation, are also discussed. Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed.

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Section: Electrospun Conductive Polymers For Nerve Tissue Engineeringmentioning

confidence: 99%

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

603

389

View full text Add to dashboard Cite

show abstract

“…The electrospun biodegradable polymers were successfully tested for their efficacy to stimulate axonal regeneration and neural stem cell differentiation, taking into account their different structural properties such as the diameter and alignment of the nanofibers. [16][17][18][19][20][21][22] The biodegradable polymers used for this purpose mostly include polylactic-co-glycolic acid (PLGA), polyvinyl alcohol (PVA), collagen, and chitosan. 23,24 Of these, PVA is a non-toxic, hydrophilic, and biocompatible material which has also been used for other tissue engineering applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of electrospun polyvinyl alcohol nanofibrous scaffolds modified by blending with chitosan for neural tissue engineering

Alhosseini¹,

Moztarzadeh²,

Mozafari³

et al. 2012

IJN

124

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Among several attempts to integrate tissue engineering concepts into strategies to repair different parts of the human body, neuronal repair stands as a challenging area due to the complexity of the structure and function of the nervous system and the low efficiency of conventional repair approaches. Herein, electrospun polyvinyl alcohol (PVA)/chitosan nano-fibrous scaffolds have been synthesized with large pore sizes as potential matrices for nervous tissue engineering and repair. PVA fibers were modified through blending with chitosan and porosity of scaffolds was measured at various levels of their depth through an image analysis method. In addition, the structural, physicochemical, biodegradability, and swelling of the chitosan nanofibrous scaffolds were evaluated. The chitosan-containing scaffolds were used for in vitro cell culture in contact with PC12 nerve cells, and they were found to exhibit the most balanced properties to meet the basic required specifications for nerve cells. It could be concluded that addition of chitosan to the PVA scaffolds enhances viability and proliferation of nerve cells, which increases the biocompatibility of the scaffolds. In fact, addition of a small percentage of chitosan to the PVA scaffolds proved to be a promising approach for synthesis of a neural-friendly polymeric blend.

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“…The scaffolds are porous and have fibers that can be tailored to affect cell differentiation, proliferation, and migration [34][35][36][37][38]. These characteristics make electrospun constructs ideal for wound dressings [39,40] and grafts for various tissues such as skin [32,[41][42][43][44][45][46], nerves [32,33,[47][48][49][50][51], vasculature [32,33,41,[51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66], muscle [33,51,67,68], bone [15,32,33,41,51,[69]…”

Section: Electrospinningmentioning

confidence: 99%

A review of electrospinning manipulation techniques to direct fiber deposition and maximize pore size

et al. 2017

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Electrospinning has been widely accepted for several decades by the tissue engineering and regenerative medicine community as a technique for nanofiber production. Owing to the inherent flexibility of the electrospinning process, a number of techniques can be easily implemented to control fiber deposition (i.e. electric/magnetic field manipulation, use of alternating current, or air-based fiber focusing) and/or porosity (i.e. air impedance, sacrificial porogen/sacrificial fiber incorporation, cryo-electrospinning, or alternative techniques). The purpose of this review is to highlight some of the recent work using these techniques to create electrospun scaffolds appropriate for mimicking the structure of the native extracellular matrix, and to enhance the applicability of advanced electrospinning techniques in the field of tissue engineering.

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Poly(l-lactide-co-glycolide) biodegradable microfibers and electrospun nanofibers for nerve tissue engineering: an in vitro study

Cited by 104 publications

References 20 publications

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Synthesis and characterization of electrospun polyvinyl alcohol nanofibrous scaffolds modified by blending with chitosan for neural tissue engineering

A review of electrospinning manipulation techniques to direct fiber deposition and maximize pore size

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