Poly-l-Lactic Acid Injected in the Temples Improves Excessive Upper Eyelid Skin

Effect of poly‐L‐lactic acid and polydioxanone biostimulators on type I and III collagen biosynthesis

“…Inducing collagenesis through the intradermal application of poly‐L‐lactic acid (PLLA) has wide validation in the literature, which confirms its performance in correcting the decrease in volume, forming structural points for repositioning the soft tissues of the face. 12 , 13 , 14 , 15 …”

“…[8][9][10] Therefore, minimally invasive procedures aimed at facial rejuvenation have brought great versatility when choosing and using collagen biostimulators, which treat fine lines and wrinkles, while correcting the loss of volume of the aged face from the induction of collagenesis, resulting in improved thickness, sagging and dermal quality 11 Inducing collagenesis through the intradermal application of poly-Llactic acid (PLLA) has wide validation in the literature, which confirms its performance in correcting the decrease in volume, forming structural points for repositioning the soft tissues of the face. [12][13][14][15] Polydioxanone (PDO) is used as an absorbable material in the form of PDO threads to induce the formation of collagen. 16 Recently, a new presentation of PDO powder is being marketed with the same indication of collagenesis activation; however, more detailed research on its performance in activating collagenesis and increasing dermal thickness and quality is still lacking.…”

Vascular anatomy of temporal fossa

“…A recent publication (2021) reported two cases where upper eyelid skin tightening was observed after poly-L-lactic acid (PLLA) treatment into the temples. 108 Another study found that the use of a posterior temporal supraperiosteal (supra)-SMAS minimally invasive lifting procedure was shown to treat temporal hollowing and age-related changes in the mid-and lower face (e.g., marionette lines and jowl deformity). 109 The investigators found that as injection of HA increased the volume of the temporal fat compartment, the skin shifted upwards.…”

“…117 PLLA has been used to rejuvenate the temporal regions. 108,118 In a retrospective review of over 130 cases, injections of PLLA into the temporal region resulted in the highest subject satisfactions rates, in comparison to treatments of the cheeks (medial and lateral), tear troughs, nasolabial folds, marionette lines, chest, hands, and thighs. In addition, PLLA has been approved by the Food and Drug Administration (FDA) for the correction of facial lipoatrophy (FLA) in patients with human immunodeficiency virus (HIV).…”