Poly-L-lactic acid — hydroxyapatite (PLLA-HA) bioabsorbable interference screws for tibial graft fixation in anterior cruciate ligament (ACL) reconstruction surgery: MR evaluation of osteointegration and degradation features

Macarini, Luca; Milillo, Paola; Mocci, A.; Vinci, Raffaele; Ettorre, G

doi:10.1007/s11547-008-0334-x

Cited by 38 publications

(31 citation statements)

References 26 publications

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“…With 54% follow-up, the authors found that all of the Biosteon interference screws (Stryker, Mahwah, New Jersey), composed of hydroxyapatite-PLLA, had been resorbed and density in the screw tracks was comparable with that in the surrounding bone. Macarini et al evaluated thirty-one patients using MRI over a forty-month period after surgery 24 . The authors found evidence of edema and cyst formation in a group of fifteen patients ten to thirteen months after implantation of hydroxyapatite-PLLA interference screws, but this resolved over time and was absent, having been replaced by fibrous tissue, on repeat MRI scans in a separate group of sixteen patients thirty to forty months after surgery.…”

Section: Discussionmentioning

confidence: 99%

Do Newer-Generation Bioabsorbable Screws Become Incorporated into Bone at Two Years After ACL Reconstruction with Patellar Tendon Graft?

Cox

Spindler

Leonard

et al. 2014

Journal of Bone and Joint Surgery

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CALAXO screws in the tibial tunnel were more likely to be rated as degraded or partially degraded compared with MILAGRO screws at a mean of three years after implantation for ACL reconstruction. Although these newer-generation bioabsorbable screws were designed to promote osseointegration, no tunnel narrowing was noted, and in the majority of cases the remains of the screws were present at approximately three years.

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Section: Discussionmentioning

confidence: 99%

Do Newer-Generation Bioabsorbable Screws Become Incorporated into Bone at Two Years After ACL Reconstruction with Patellar Tendon Graft?

Cox

Spindler

Leonard

et al. 2014

Journal of Bone and Joint Surgery

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show abstract

“…In fact, one study completed a 10-year follow-up and found that all patients had an osseous cyst in the place of the degraded screws as observed with MRI (Warden et al 2008). To address the problem of osteointegration, biocomposite materials, composed of polyesters combined with ceramic particles (typically tricalcium phosphate [TCP] or hydroxyapatite), have been recently introduced (Macarini et al 2008;Tecklenburg et al 2006;Hunt and Callaghan 2008;LeGeros 2002;Tay et al 1999;Lu et al 2009). However, their effectiveness in terms of osteointegration has been promising but inconclusive (Warden et al 2008;Barber and Dockery 2008), and breakage during implantation still remains a significant problem for these polymer-based materials (Tecklenburg et al 2006).…”

Section: Need For Novel Biomaterials and Devicesmentioning

confidence: 99%

Nanotechnology Enabled In situ Sensors for Monitoring Health

2011

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except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. PrefaceNanotechnology is the use of materials with at least one direction less than 100 nm, so called nanomaterials. Examples of common nanomaterials include particles, fibers, tubes, coating features, etc. all with at least one dimension less than 100 nm. Nanotechnology has already begun to revolutionize numerous science and engineering fields, including, but not limited to fabricating faster and more light-weight computers, stronger buildings (even the consideration of building an elevator from the earth to the moon), improved catalytic devices, and medicine where several nanomaterials have been FDA approved for clinical use. In medicine, numerous researchers are searching for ways to make medicine more personal, and, nanotechnology may provide the answer. Imagine the day when we can utilize sensors placed in various parts throughout the body to determine, in real-time, biological events. Moreover, imagine a day when that same device can send information from inside to outside the body to help a clinician treat a medical problem that would be diagnosed using traditional medical imaging. Lastly, imagine a day when that same device could be programmed to reverse adverse biological events to ensure a healthier, more active patient. This book will examine the role that nanomaterials are playing in the above, specifically, in designing sensors that can diagnosis and treat diseases inside the body.To introduce the reader to this exciting and fast-moving subject, this book will first provide a forward from the medical device industry concerning the importance of developing in situ sensors to diagnosis and treat diseases in ways we are currently not able to (since, after all, the best way to a fight disease or a medical problem is at the site at which it occurs, not necessarily through conventional systemic drug delivery which takes time and efficacy is lost as drugs pass through the body partially ending up at the disease location). The first chapter will then describe fundamentals of cancer and how in situ sensors are being used to treat cancer. Clearly, cancer remains one of our foremost diseases and nanotechnology-derived sensors are making much progress towards a personalized care of select cancers. The second chapter will then cover the fundamentals of how our tissues heal and how nanosensors can be used to promote tissue healing. Excessive inflammation (often leading to scar tissue growth) and infection often disrupt healing. Thus, the third chapter will cover the fundamentals of inflammation and infection a...

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“…Degradation kinetics differ substantially among different bioabsorbable polymers and numerous factors affect degradation rates, including molecular weight, sterilization, implant size, self-reinforcement, copolymer or stereocopolymer ratios, and processing techniques [2]. Postoperative radiographic evaluation of early generation poly-L-lactic acid (PLLA), polyglycolide and poly-D,L-lactide-co-glycolide screws revealed slow resorption rates and minimal, if any, osteoconductivity, despite good to excellent clinical results [3][4][5][6][7][8][9][10][11]. The addition of β-tricalcium phosphate (βTP) or hydroxyapatite (HA) helps buffer PLLA acidic breakdown providing a scaffold for bony ingrowth [12,13].…”

Section: Introductionmentioning

confidence: 99%

In situ comparison of varying composite tibial tunnel interference screws used for ACL soft tissue graft fixation

et al. 2015

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Poly-L-lactic acid — hydroxyapatite (PLLA-HA) bioabsorbable interference screws for tibial graft fixation in anterior cruciate ligament (ACL) reconstruction surgery: MR evaluation of osteointegration and degradation features

Cited by 38 publications

References 26 publications

Do Newer-Generation Bioabsorbable Screws Become Incorporated into Bone at Two Years After ACL Reconstruction with Patellar Tendon Graft?

Do Newer-Generation Bioabsorbable Screws Become Incorporated into Bone at Two Years After ACL Reconstruction with Patellar Tendon Graft?

Nanotechnology Enabled In situ Sensors for Monitoring Health

In situ comparison of varying composite tibial tunnel interference screws used for ACL soft tissue graft fixation

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