Poly-L-arginine Coated Silver Nanoprisms and Their Anti-Bacterial Properties

Abstract

The aim of this study was to test the effect of two different morphologies of silver nanoparticles, spheres, and prisms, on their antibacterial properties when coated with poly-L-arginine (poly-Arg) to enhance the interactions with cells. Silver nanoparticle solutions were characterized by UV–visible spectroscopy, transmission electron microscopy, dynamic light scattering, zeta potential, as well as antimicrobial tests. These ultimately showed that a prismatic morphology exhibited stronger antimicrobial effects against Escherichia coli, Pseudomonas aeruginosa and Salmonella enterica. The minimum bactericidal concentration was found to be 0.65 μg/mL in the case of a prismatic AgNP-poly-Arg-PVP (silver nanoparticle-poly-L-arginine-polyvinylpyrrolidone) nanocomposite. The anticancer cell activity of the silver nanoparticles was also studied, where the maximum effect against a HeLa cell line was 80% mortality with a prismatic AgNP-poly-Arg-PVP nanocomposite at a concentration of 11 μg/mL. The antimicrobial activity of these silver nanocomposites demonstrates the potential of such coated silver nanoparticles in the area of nano-medicine.

Comparative Effects of Particle Sizes of Cobalt Nanoparticles to Nine Biological Activities

“…Of the various properties of NPs that affect bacterial activity, solubilized metal ions from MNPs may be responsible for the observed inhibitory effects [27]. Positively charged metal ions from NPs would likely interact on the cell surface of Gram-negative bacteria, which is negatively charged at near-neutral pH due to the presence of lipopolysaccharides, potentially leading to inhibition of enzyme biosynthesis [28]. In this study, soluble cobalt concentrations were measured for bacterial bioluminescence strain experiments to determine the contribution of soluble metal concentrations on bacterial activity.…”

The effect of nanoencapsulation of ICG on two-photon bioimaging

“…[33][34][35][36][37][38][39] Additionally, it is a semi-essential amino-acid with various roles such as in cell metabolism, wound healing, protein synthesis, and it also shows antimicrobial and antitumor activity. [40][41][42][43][44][45] In particular, owing to their favorable properties, NPs comprised of PLA have garnered considerable interest for delivery of small molecules. [46][47][48] Hence, the synthesis of ICG-PLA NPs would not only help in cellular delivery but also would improve the optical stability of ICG.…”

Preparation and In-Vitro Assessment of Hierarchal Organized Antibacterial Breath Mask Based on Polyacrylonitrile/Silver (PAN/AgNPs) Nanofiber

“…However, many antibacterial additives such as phenols, inorganic salts, organometallics [ 5 ], organic material like honey [ 7 ], and metallic nanoparticles, as well as zinc oxide, titanium oxide [ 8 ], and silver nanoparticles (AgNPs) [ 9 ] with chemical characteristics [ 10 , 11 , 12 ] have been used in electrospun nanofibers for wound dressings. However, silver nanoparticles among the antibacterial materials showed the greatest potential to be employed in various fields such as biomedical textiles [ 13 ] or electronics [ 14 ], thanks to their unique properties in electroconductivity and antibacterial activity [ 15 ].…”