Poly(ionic liquid)/Ce‐Based Antimicrobial Nanofibrous Membrane for Blocking Drug‐Resistance Dissemination from MRSA‐Infected Wounds

Abstract

Resistant bacteria have become a global threat. Even if bacteria are killed, their carried drug‐resistant genes can remain in the environment and spread to other microbes via horizontal gene transfer. Development of antimicrobial materials with intrinsic gene break down activity can prevent the dissemination of released drug‐resistant genes from the dead bacteria. Herein, imidazolium type poly(ionic liquid) (PIL)/cerium (IV) ion‐based electrospun nanofibrous membranes (PIL‐Ce) are synthesized. The effects of PIL and Ce moieties on the antimicrobial properties against Gram‐negative Escherichia coli and kanamycin‐resistant E. coli, and Gram‐positive Staphylococcus aureus and methicillin‐resistant S. aureus (MRSA), as well as deoxyribonuclease‐mimic activities to the drug‐resistant genes of KanR (E. coli) and mecA (MRSA) are investigated. The Ce‐containing PIL membranes show the high efficiencies to eradicate bacteria and disintegrate drug‐resistant genes. A wound treatment test using MRSA infected mice as the model further demonstrate that PIL‐Ce membranes combine both antibacterial and DNase‐mimic properties, and may have the potential application as a new “green” wound dressing to block the drug resistance spread in a clinical setting.

Moisture‐Wicking, Breathable, and Intrinsically Antibacterial Electronic Skin Based on Dual‐Gradient Poly(ionic liquid) Nanofiber Membranes

“…As a result, they exhibit a broad spectrum of antibacterial characteristics and have been extensively investigated as antimicrobial materials. [51][52][53] Herein, we fabricated an electronic skin with moisturewicking and breathable properties, which can be used for monitoring bioelectronic signals. The electronic skin of the PIL-based nanofiber membrane (PIL membrane) comprises multilayer PIL nanofibers with a considerable dual gradient of hydrophilicity and pore size in the longitudinal direction.…”

A Cation‐Methylene‐Phenyl Sequence Encodes Programmable Poly(Ionic Liquid) Coacervation and Robust Underwater Adhesion

“…[28] Our work introduces a modular preparation of coacervation driven by cation-π interactions in poly(ionic liquid)s (PILs), a sub-class of polyelectrolytes with intriguing properties and materials functionalities. [29][30][31][32] A "cation-methylene-phenyl" (C-M-P) motif which combines cations and π entities was designed and built into the ionic liquid (IL) monomers. The synthesis of IL monomers requires only a one-step quaternization.…”

“…Importantly, this design enables the unprecedented modular formation of PILs coacervates without hindering the various other beneficial properties of PILs. [29][30][31][32] The C-M-P sequence was explicitly translated into saline-triggered coacervation and exhibited unprecedented wet adhesion in marine applications.…”

The synthesis and application of poly(ionic liquid)s functional materials

“…王树教授等 [90] 吸收性能(q=410 mg g -1 )，有望用于多组分废水的处理 41 [97] . 42 43 图 17 PIL-Ce 纳米纤维膜的制备流程图以及其杀死细 44 菌分解耐药基因(ARGs)示意图 [98] . 45…”

“…Figure 17 Synthesis of poly(ionic liquid)/Ce-based 46 nanofibrous membranes (PIL-Ce) for killing bacteria and 47 decomposing antibiotic resistance genes (ARGs) [98] . 48 49 此外，聚离子液体的呈现形式多样，可以通过调 50…”