Poly (<i>ɛ</i>-Caprolactone-<i>co</i>-<scp>l</scp>,<scp>l</scp>-Lactide) Vascular External Sheath Carrying Prednisone for Improving Patency Rate of the Vein Graft

Wang, Yang; Tao, Meihan; Wei, Huan; Ma, Yizhan; Mao, Xiaoyan; Liang, H.; Ao, Qiang

doi:10.1089/ten.tea.2021.0118

Cited by 4 publications

(7 citation statements)

References 43 publications

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“…The placement of a biodegradable copolymer, poly (εcaprolactone-co-L, L-lactide), with prednisone sheaths around vein graft in a rabbit CABG model successfully prevented the expansion of the graft and slowly released prednisone to effectively inhibit intimal hyperplasia. 32 Moreover, the same significant outcome could be observed in the biodegradable external sheath carrying slow release bosentan in an animal model. 39 The novel complex electro-spun external sheath, which can timedependently and slowly release loaded fasudil dihydrochloride, everolimus, and simvastatin, had prevented neointimal hyperplasia and graft stenosis.…”

Section: Discussionmentioning

confidence: 55%

“…Considering the multiple mechanisms and the different periods of the pathophysiology of SVG failure, drug eluting stenting, which contains a combination of different inhibitors, has emerged. The placement of a biodegradable copolymer, poly (ε‐caprolactone‐co‐L, L‐lactide), with prednisone sheaths around vein graft in a rabbit CABG model successfully prevented the expansion of the graft and slowly released prednisone to effectively inhibit intimal hyperplasia 32 . Moreover, the same significant outcome could be observed in the biodegradable external sheath carrying slow release bosentan in an animal model 39 .…”

Section: Discussionmentioning

confidence: 71%

“…Our analysis showed that the external support devices did not significantly increase the overall SVG failure rate (≥ 50% stenosis) and SVG occlusion (99%–100% stenosis) compared with non‐stents support SVGs in the short follow‐up period. The graft patency was in influenced by many factors 29 such as target artery quality and runoff, quality of the SVG, SVG harvest technique (open harvest or endoscopic harvest, no‐touch harvest or skeletonized harvest), 30 side branch ligation (suture or metallic clips), 31 stent material and size, 32,33 and flow patterns 34 in the external stented SVGs. The post‐analysis of the VEST at 3 years showed that the open SVG harvest technique was associated with graft patency compared to endoscopic SVG harvest 29 .…”

Section: Discussionmentioning

confidence: 99%

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External stenting for saphenous vein grafts in coronary artery bypass grafting: A meta‐analysis

Chen

Wang

et al. 2023

Eur J Clin Investigation

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ObjectivesAutologous saphenous vein grafts (SVGs) are the most commonly used bypass conduits in coronary artery bypass grafting (CABG) with multivessel coronary artery disease. Although external support devices for SVGs have shown promising outcomes, the overall efficacy and safety remains controversial. We aimed to evaluate external stenting for SVGs in CABG versus non‐stented SVGs.MethodsMEDLINE, EMBASE, Cochrane Library and clinicaltrails.gov were searched for randomized controlled trials (RCTs) to evaluate external‐stented SVGs versus non‐stented SVGs in CABG up to 31 August 2022. The risk ratio and mean difference with 95% confidence interval were analysed. The primary efficacy outcomes included intimal hyperplasia area and thickness. The secondary efficacy outcomes were graft failure (≥50% stenosis) and lumen diameter uniformity.ResultsWe pooled 438 patients from three RCTs. The external stented SVGs group showed significant reductions in intimal hyperplasia area (MD: −0.78, p < 0.001, I2 = 0%) and thickness (MD: −0.06, p < 0.001, I2 = 0%) compared to the non‐stented SVGs group. Meanwhile, external support devices improved lumen uniformity with Fitzgibbon I classification (risk ratio (RR):1.1595, p = 0.05, I2 = 0%). SVG failure rates were not increased in the external stented SVGs group during the short follow‐up period (RR: 1.14, p = 0.38, I2 = 0%). Furthermore, the incidences of mortality and major cardiac and cerebrovascular events were consistent with previous reports.ConclusionsExternal support devices for SVGs significantly reduced the intimal hyperplasia area and thickness, and improved the lumen uniformity, assessed with the Fitzgibbon I classification. Meanwhile, they did not increase the overall SVG failure rate.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

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External stenting for saphenous vein grafts in coronary artery bypass grafting: A meta‐analysis

Chen

Wang

et al. 2023

Eur J Clin Investigation

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“…25,47 The addition of PEG and BG increased the swelling ratio 46 PLCL alone exhibited a gradual degradation profile, with approximately 7% degradation observed on day 45 of the assay, consistent with the findings of a previous study. 50 Thermal gravimetric analysis (Figure 4F) provided evidence of efficient bioglass incorporation. This analysis measures the changes in mass concerning temperature over time.…”

Section: Discussionmentioning

confidence: 97%

Biodegradable electrospun poly(L‐lactide‐co‐ε‐caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering

de Souza,

Cardoso,

de Toledo

et al. 2024

J Biomed Mater Res

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The field of tissue engineering has witnessed significant advancements in recent years, driven by the pursuit of innovative solutions to address the challenges of bone regeneration. In this study, we developed an electrospun composite scaffold for bone tissue engineering. The composite scaffold is made of a blend of poly(L‐lactide‐co‐ε‐caprolactone) (PLCL) and polyethylene glycol (PEG), with the incorporation of calcined and lyophilized silicate‐chlorinated bioactive glass (BG) particles. Our investigation involved a comprehensive characterization of the scaffold's physical, chemical, and mechanical properties, alongside an evaluation of its biological efficacy employing alveolar bone‐derived mesenchymal stem cells. The incorporation of PEG and BG resulted in elevated swelling ratios, consequently enhancing hydrophilicity. Thermal gravimetric analysis confirmed the efficient incorporation of BG, with the scaffolds demonstrating thermal stability up to 250°C. Mechanical testing revealed enhanced tensile strength and Young's modulus in the presence of BG; however, the elongation at break decreased. Cell viability assays demonstrated improved cytocompatibility, especially in the PLCL/PEG+BG group. Alizarin red staining indicated enhanced osteoinductive potential, and fluorescence analysis confirmed increased cell adhesion in the PLCL/PEG+BG group. Our findings suggest that the PLCL/PEG/BG composite scaffold holds promise as an advanced biomaterial for bone tissue engineering.

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“…In recent years, PLCL has been widely studied for the regeneration of soft tissue, such as blood vessels, tendons, skin, esophageal tissue, and heart tissue, due to its good biocompatibility, controlled degradation, and excellent flexibility ( Jang et al, 2018 ; Wang et al, 2022 ). Blood vessels require a degree of strength to withstand high blood pressure.…”

Section: Introductionmentioning

confidence: 99%

Preparation and performance of random- and oriented-fiber membranes with core–shell structures via coaxial electrospinning

Jin²,

Fan³

et al. 2023

Front. Bioeng. Biotechnol.

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The cells and tissue in the human body are orderly and directionally arranged, and constructing an ideal biomimetic extracellular matrix is still a major problem to be solved in tissue engineering. In the field of the bioresorbable vascular grafts, the long-term functional prognosis requires that cells first migrate and grow along the physiological arrangement direction of the vessel itself. Moreover, the graft is required to promote the formation of neointima and the development of the vessel walls while ensuring that the whole repair process does not form a thrombus. In this study, poly (l-lactide-co-ε-caprolactone) (PLCL) shell layers and polyethylene oxide (PEO) core layers with different microstructures and loaded with sodium tanshinone IIA sulfonate (STS) were prepared by coaxial electrospinning. The mechanical properties proved that the fiber membranes had good mechanical support, higher than that of the human aorta, as well as great suture retention strengths. The hydrophilicity of the oriented-fiber membranes was greatly improved compared with that of the random-fiber membranes. Furthermore, we investigated the biocompatibility and hemocompatibility of different functional fiber membranes, and the results showed that the oriented-fiber membranes containing sodium tanshinone IIA sulfonate had an excellent antiplatelet adhesion effect compared to other fiber membranes. Cytological analysis confirmed that the functional fiber membranes were non-cytotoxic and had significant cell proliferation capacities. The oriented-fiber membranes induced cell growth along the orientation direction. Degradation tests showed that the pH variation range had little change, the material mass was gradually reduced, and the fiber morphology was slowly destroyed. Thus, results indicated the degradation rate of the oriented-fiber graft likely is suitable for the process of new tissue regeneration, while the random-fiber graft with a low degradation rate may cause the material to reside in the tissue for too long, which would impede new tissue reconstitution. In summary, the oriented-functional-fiber membranes possessing core–shell structures with sodium tanshinone IIA sulfonate/polyethylene oxide loading could be used as tissue engineering materials for applications such as vascular grafts with good prospects, and their clinical application potential will be further explored in future research.

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Poly (ɛ-Caprolactone-co-l,l-Lactide) Vascular External Sheath Carrying Prednisone for Improving Patency Rate of the Vein Graft

Cited by 4 publications

References 43 publications

External stenting for saphenous vein grafts in coronary artery bypass grafting: A meta‐analysis

External stenting for saphenous vein grafts in coronary artery bypass grafting: A meta‐analysis

Biodegradable electrospun poly(L‐lactide‐co‐ε‐caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering

Preparation and performance of random- and oriented-fiber membranes with core–shell structures via coaxial electrospinning

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