Poly(ethylene glycol) Surface Coated Magnetic Particles

Flesch, Christophe; Unterfinger, Yves; Bourgeat‐Lami, Élodie; Duguet, Étienne; Delaite, Christelle; Dumas, Philippe

doi:10.1002/marc.200500402

Cited by 50 publications

(43 citation statements)

References 23 publications

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“…It is worth to mention that poly(ethylene glycol) (PEG) is one of the polymers most commonly employed in nano-biomedicine, due to its biocompatibility and steric repulsion features. It is possible to find in the literature many different ways under which PEG can be bound onto magnetic nanoparticles, to mention a few: sol-gel technique (Gupta et al, 2007), polymerization in the presence of nanoparticles (Flesch et al, 2005), implantation of silane groups on the surface of the nanoparticles (Pilloni et al, 2010) among others. Besides PEG, dextran is another candidate largely used as surface modifying agent.…”

Section: Stabilization Methodsmentioning

confidence: 99%

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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In this paper we describe the preparation and characterization of magnetic nanocomposites designed for applications in targeted drug delivery. Combining superparamagnetic behavior with proper surface functionalization in a single entity makes it possible to have altogether controlled location and drug loading, and release capabilities. The colloidal vehicles consist of maghemite (γ-Fe2O3) cores surrounded by a gold shell through an intermediate silica coating. The external Au layer confers the particles a high degree of biocompatibility and reactive sites for the transported drug binding. In addition, it permits to take advantage of the strong optical resonance, making it easy to visualize the particles or even control their payload release through temperature changes. The results of the analysis of relaxivity demonstrate that these nanostructures can be used as T 2 contrast agents in magnetic resonance imaging (MRI), but the magnetic cores will be mainly useful in manipulating the particles using external magnetic fields. We describe how optical absorbance and electrokinetic data provide a followup of the progress of the nanostructure formation. Additionally, these techniques, together with confocal microscopy, are employed to demonstrate that the component nanoparticles are capable of loading significant amounts of the antitumor drug doxorubicin, very efficient in the chemotherapy of a wide range of tumors. Colon adenocarcinoma cells were used to test the in vitro release capabilities of the drug-loaded nanocomposites.

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Section: Stabilization Methodsmentioning

confidence: 99%

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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“…Ring-opening polymerization (ROP) has also been employed to obtain IONPs coated with linear biodegradable poly(esters) [19] or hyper-branched polymers [20]. Finally, a grafting 'through' method has been described using IONPs coated with methacrylic bonds to yield well-dispersed particle solutions [21].…”

Section: Stabilization Of Ionps Using Polymer Chainsmentioning

confidence: 99%

“…Polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA) and PEG have also been used to stabilize IONPs [3,21]. These polymers are widely termed 'biocompatible', however both PVA and PVP can adsorb proteins through hydrogen-bonding interactions [35].…”

Section: Polymer Propertiesmentioning

confidence: 99%

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

et al. 2010

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Iron-oxide nanoparticles (IONPs) represent a significant class of inorganic nanomaterial that is contributing to the current revolution in nanomedicine [1][2]. Their unique physical properties, including high surface area to volume ratios and superparamagnetism, confer useful attributes for medical applications such as magnetic resonance imaging (MRI), drug and gene delivery, tissue engineering and bioseparation [3].Two distinct classes of superparamagnetic IONP-based materials are currently used for medical applications: superparamagnetic iron-oxide (SPIO) nanoparticles with a mean particle diameter of 50-100 nm, and ultra-small superparamagnetic iron-oxide (USPIO) nanoparticles with a size below 50 nm. Th ese two classes of IONPs have been studied widely for medical applications, particularly as the next (potential) generation of MRI contrast agents. Th ey are also seen as potential vectors for drug and gene delivery. Th e biodistribution of these nanoparticles can be altered by the application of an external magnetic fi eld; they also have potential applications in hyperthermia therapy as some magnetic particles can heat up under the infl uence of a localized high-frequency magnetic fi eld.Th e intent of this review is to present recent advances in the synthesis of IONPs and their subsequent stabilization in biological fluids using polymers, focusing on the current strategies used to graft polymers onto IONPs surfaces (see Figure 1) and the diff erent types of polymers used. Th e additional properties conferred by the polymers, such as targeting, eff ects on biodistribution and pharmacokinetics, are also discussed, and the main applications of IONPs are reviewed. Synthesis and properties of iron-oxide nanoparticlesSPIO and USPIO nanoparticles are the most extensively studied magnetic nanoparticles for biomedical applications as they are both biocompatible and easy to synthesize. Both are composed of ferrite nanocrystallites of magnetite (Fe 3 O 4 ) or maghemite (Fe 2 O 3 , γ). Over the last ten years, there has been an explosion of interest in these materials and this has been reflected in a large number of recent publications describing the synthesis and modifi cation of hybrid IONPs. In this review, we focus on the polymer modifi cation of the nanoparticles, and provide only minimal information on the inorganic synthesis of IONPs. For more detailed information on IONP synthesis, readers are referred to other reviews [3,4]. The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applicationsCyrille Boyer 1 * , Michael R. Whittaker 1 , Volga Bulmus 2 , Jingquan Liu 1 and Thomas P. Davis 1 * University of New South Wales, AustraliaOver the past decade, the synthesis of superparamagnetic nanoparticles, especially iron-oxide nanoparticles (IONPs), has been researched intensively for many high-technology applications, including enhanced storage media, biosensing and medical applications. In medicine, IONPs are used as contrast agents in magnetic resonance imaging and in hyperthermia...

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“…Mechanisms of preventing opsonization by PEG include the shielding of the surface charges, increased surface hydrophilicity (Gabizon & Papahadjopoulos, 1992), and enhanced repulsive interaction between polymer-coated nanoparticles and blood components (Needham et al, 1992). Various methods have been utilized to attach PEG to the MNP surface, including silane grafting to the oxide surface (Butterworth et al, 2001), alkaline coprecipitation of ferric and ferrous ions in the presence of PEG-containing block copolymers (Wan et al, 2005), direct attachment of PEG-containing block copolymers (Guo et al, 2010), polymerization at the MNP surface (Flesch et al, 2005), and modification through sol-gel approaches (Y. Lu et al, 2002).…”

Section: Polymer Coatingsmentioning

confidence: 99%