Poly(ethylene glycol) shell-sheddable TAT-modified core cross-linked nano-micelles: TAT-enhanced cellular uptake and lysosomal pH-triggered doxorubicin release

Zhang, Yuliu; Xiao, Yi; Huang, Yushu; He, Yang; Xu, Yanyun; Lü, Wei; Yu, Jiahui

doi:10.1016/j.colsurfb.2020.110772

Cited by 20 publications

(13 citation statements)

References 36 publications

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“…Details of the synthesis route of the redox-sensitive polymer, HA-ss-PLLZ, are presented in Supplementary Figure S1 . Polymers with low critical micelle concentrations (CMC) may overcome the effects of hemodilution, thereby avoiding premature drug leakage in the blood circulation (Hu et al., 2016 ; Zhang et al., 2020 ). Moreover, an appropriate size may be required to maximize nanomedicine accumulation in tumor sites mediated by the enhanced permeability and retention (EPR) effect (Kinoshita et al., 2017 ).…”

Section: Resultsmentioning

confidence: 99%

Hyaluronic acid reduction-sensitive polymeric micelles achieving co-delivery of tumor-targeting paclitaxel/apatinib effectively reverse cancer multidrug resistance

et al. 2020

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Multidrug resistance (MDR) of cancer cells is a significant challenge in chemotherapy, highlighting the urgent medical need for simple and reproducible strategies to reverse this process. Here, we report the development of an active tumor-targeting and redox-responsive nanoplatform (PA-ss-NP) using hyaluronic acid- g -cystamine dihydrochloride-poly-ε-(benzyloxycarbonyl)-L-lysine (HA-ss-PLLZ) to co-deliver paclitaxel (PTX) and apatinib (APA) for effective reversal of MDR. This smart nanoplatform specifically bound to CD44 receptors, leading to selective accumulation at the tumor site and uptake by MCF-7/ADR cells. Under high concentrations of cellular glutathione (GSH), the nanocarrier was degraded rapidly with complete release of its encapsulated drugs. Released APA effectively inhibited the function of the P-glycoprotein (P-gp) drug pump and improved the sensitivity of MDR cells to chemotherapeutic agents, leading to the recovery of PTX chemosensitivity in MDR cells. As expected, this newly developed intelligent drug delivery system could effectively control MDR, both in vitro and in vivo .

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Section: Resultsmentioning

confidence: 99%

Hyaluronic acid reduction-sensitive polymeric micelles achieving co-delivery of tumor-targeting paclitaxel/apatinib effectively reverse cancer multidrug resistance

et al. 2020

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“…23,29,51 Transition metal coordination complexes may also be implemented as pH responsive cross-linkers. 52 The metal center and cross-linking ligands are strategically selected, forming coordination bonds between them that can be cleaved at acidic pH. The higher concentration of free protons in the tumor microenvironment can also interfere with electrostatic interactions that hold different components of drug delivery platforms together.…”

Section: ■ Moieties For Stimuli Responsivenessmentioning

confidence: 99%

“…Zhang et al reported the use of the Fe(III) coordination complex, where two separate catechol groups from individual copolymer chains would result in cross-linking of the nanomicelle system. 52 Under acidic conditions, most notably in the lysosome, the protonation of oxygen donors yields mono coordination complexes, where only one catechol coordinates with the iron center. Because of the disruption of the coordination complex and thus totality of the system, disassembly of the nanomicelles is facilitated under acidic conditions.…”

Section: ■ Modes Of Enhancing Therapeutics Upon Stimuli Exposurementioning

confidence: 99%

“…Hydrazone bonds offer both stability from their covalent nature and stimuli responsiveness as they are readily hydrolyzed under acidic conditions . These bonds can be incorporated as cross-linkers to stabilize drug delivery vessels under physiological conditions and as connectors between anticancer agents and polymer carriers to create prodrugs. ,, Transition metal coordination complexes may also be implemented as pH responsive cross-linkers . The metal center and cross-linking ligands are strategically selected, forming coordination bonds between them that can be cleaved at acidic pH.…”

Section: Moieties For Stimuli Responsivenessmentioning

confidence: 99%

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Utilizing Stimuli Responsive Linkages to Engineer and Enhance Polymer Nanoparticle-Based Drug Delivery Platforms

Hershberger

Gauger

Bronstein

2021

ACS Appl. Bio Mater.

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The devastating nature of cancer continues to be one of the leading causes of death in the world. Chemotherapy is among the most common forms of cancer treatment but comes with a host of adverse effects caused by the therapeutic agents damaging healthy tissue and organs. To limit these side effects, scientists have been designing stimuli responsive drug delivery vessels for targeted release. This Review focuses on the incorporation of stimuli responsive linkages in targeted drug delivery systems to enhance therapeutic efficiency. These platforms are primarily employed to control the distribution of anticancer agents in the body to reduce the adverse side effects caused by their toxicities. We will outline how drug delivery vessels are constructed so that exposure to select environmental and external stimuli releases the enclosed drug only at the target site. Stimuli responsive components are integrated within drug delivery vessels in the form of cross-linkers, polymers, and surface modifications. The changes, these moieties undergo upon stimuli exposure, cascade into larger scale alterations to the platforms, resulting in complete disassembly, reversible morphological variations, and enhanced cellular uptake. The ability for these modes of delivery to be initiated exclusively under stimuli exposure allows for release of toxic therapeutic agents to be confined only to the affected area.

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“…Chu et al [47] used cystamine-modified mPEG as a macroinitiator to initiate the polymerization of BLA-NCA, and then obtained a redox-responsive mPEG-block-PASPAm derivative, which contains a disulfide linkage between mPEG segment and PASPAm segment. Redox-responsive PASPAm derivatives, which have mPEG pendants with disulfide linkages, can also be synthesized through grafting 3,3'-dithiodipropionic acid-modified mPEG [74] or the aminolysis reaction between PSI and amino-terminated disulfide functionalized mPEG [48]. Moreover, some cationic polymers [75,76] or other compounds [77] can also be functionalized with cystamine and then used to design reduction-responsive PASPAm derivatives for DNA/RNA delivery.…”

Section: Redox-responsive Poly(aspartamide) Derivativesmentioning

confidence: 99%

Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers

Zhang

Bao

2021

IJMS

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Poly(aspartamide) derivatives, one kind of amino acid-based polymers with excellent biocompatibility and biodegradability, meet the key requirements for application in various areas of biomedicine. Poly(aspartamide) derivatives with stimuli-responsiveness can usually respond to external stimuli to change their chemical or physical properties. Using external stimuli such as temperature and pH as switches, these smart poly(aspartamide) derivatives can be used for convenient drug loading and controlled release. Here, we review the synthesis strategies for preparing these stimuli-responsive poly(aspartamide) derivatives and the latest developments in their applications as drug carriers.

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Poly(ethylene glycol) shell-sheddable TAT-modified core cross-linked nano-micelles: TAT-enhanced cellular uptake and lysosomal pH-triggered doxorubicin release

Cited by 20 publications

References 36 publications

Hyaluronic acid reduction-sensitive polymeric micelles achieving co-delivery of tumor-targeting paclitaxel/apatinib effectively reverse cancer multidrug resistance

Hyaluronic acid reduction-sensitive polymeric micelles achieving co-delivery of tumor-targeting paclitaxel/apatinib effectively reverse cancer multidrug resistance

Utilizing Stimuli Responsive Linkages to Engineer and Enhance Polymer Nanoparticle-Based Drug Delivery Platforms

Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers

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