Poly(ethylene glycol)–poly(lactic-co-glycolic acid) based thermosensitive injectable hydrogels for biomedical applications

Alexander, Amit; AJAZUDDIN, .; Khan, Junaid; Saraf, Swarnlata; Saraf, Shailendra

doi:10.1016/j.jconrel.2013.10.006

Cited by 153 publications

(75 citation statements)

References 142 publications

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“…A variety of biomaterials, both natural and synthetic, have been exploited to prepare injectable hydrogels; these biomaterials include chitosan, 43 collagen or gelatin, 48,49 alginate, 50 hyaluronic acid, 51 heparin, 52 chondroitin sulfate, 53 poly(ethylene glycol) (PEG), 54 and poly(vinyl alcohol). 55 Injectable hydrogels can be fabricated through both physical and chemical methods.…”

Section: Introductionmentioning

confidence: 99%

Injectable hydrogels for cartilage and bone tissue engineering

et al. 2017

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Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix (ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed.

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Section: Introductionmentioning

confidence: 99%

Injectable hydrogels for cartilage and bone tissue engineering

et al. 2017

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“…Thermoreversible injectable systems have gained attention due to their non-invasiveness, compared to the other localized implantable systems, with the ability to carry therapeutic agents for site specific delivery, prolonged drug action and improved patient compliance (Alexander et al, 2013;Supper et al, 2014). Their ability to deliver chemotherapeutic agents intratumorally or intralesionally has been explored as a potential strategy to maximize anti-tumor effect, reduce systemic toxicity providing a continuous and sustained drug delivery (Kim et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Defining cisplatin incorporation properties in thermosensitive injectable biodegradable hydrogel for sustained delivery and enhanced cytotoxicity

Abdel-Bar

Abdel-Reheem

Osman

et al. 2014

International Journal of Pharmaceutics

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“…In the use of functional hydrogel for treating articular cartilage damage, suitable manufacture approaches and superb bio-materials act as important parts in developing perfect injectable polymeric hydrogels which could be considered as bio-scaffolds for bone and articular cartilage tissue engineering uses. A choice of biomedical materials, either synthetic or natural, has been elucidated to fabricate injectable polymeric hydrogels; those materials comprise poly(vinyl alcohol) [69], poly(ethylene glycol) (PEG) [70] or collagen, hyaluronic acid [71] (Figure 2, [72]), alginate [73], Advances in Materials Science and Engineeringchondroitin sulfate [74], heparin [75], gelatin [76,77] ( Figure 3, [78]), and chitosan [79]. Injectable polymeric hydrogel enables to be prepared via both chemical and physical ways.…”

Section: Different Treatments For Articular Cartilage Damage (Healingmentioning

confidence: 99%

Hydrogels for the Application of Articular Cartilage Tissue Engineering: A Review of Hydrogels

Chuang

Chiang

Wong

et al. 2018

Advances in Materials Science and Engineering

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e treatment of articular cartilage damage is a major task in the medical science of orthopedics. Hydrogels possess the ability to form multifunctional cartilage grafts since they possess polymeric swellability upon immersion in an aqueous phase. Polymeric hydrogels are capable of physiological swelling and greasing, and they possess the mechanical behavior required for use as articular cartilage substitutes. e chondrogenic phenotype of these materials may be enhanced by embedding living cells. Artificial hydrogels fabricated from biologically derived and synthesized polymeric materials are also used as tissue-engineering scaffolds; with their controlled degradation profiles, the release of stimulatory growth factors can be achieved. In order to make use of these hydrogels, cartilage implants were formulated in the laboratory to demonstrate the bionic mechanical behaviors of physiological cartilage. is paper discusses developments concerning the use of polymeric hydrogels for substituting injured cartilage tissue and assisting tissue growth. ese gels are designed with consideration of their polymeric classification, mechanical strength, manner of biodegradation, limitations of the payload, cellular interaction, amount of cells in the 3D hydrogel, sustained release for the model drug, and the different approaches for incorporation into adjacent organs. is article also summarizes the different advantages, disadvantages, and the future prospects of hydrogels.

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Poly(ethylene glycol)–poly(lactic-co-glycolic acid) based thermosensitive injectable hydrogels for biomedical applications

Cited by 153 publications

References 142 publications

Injectable hydrogels for cartilage and bone tissue engineering

Injectable hydrogels for cartilage and bone tissue engineering

Defining cisplatin incorporation properties in thermosensitive injectable biodegradable hydrogel for sustained delivery and enhanced cytotoxicity

Hydrogels for the Application of Articular Cartilage Tissue Engineering: A Review of Hydrogels

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