Poly(ethylene glycol) methacrylate hydrolyzable microspheres for transient vascular embolization

Louguet, Stéphanie; Verret, Valentin; Bédouet, Laurent; Servais, Emeline; Pascale, Florentina; Wassef, Michel; Labarre, Denis; Laurent, Alexandre; Moine, Laurence

doi:10.1016/j.actbio.2013.11.028

Cited by 45 publications

(36 citation statements)

References 39 publications

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“…Gelatin sponge provides quick embolization at a low material cost. The flow reduction is temporary, with most vessels recanalizing between 3 weeks and 4 months [7,49]. Recanalization, however, is unpredictable and may not occur at all.…”

Section: Commercially Available Materialsmentioning

confidence: 99%

“…Composed of cross-linked hydrolyzed starch, amilomeres, material half-life is approximately 40 min per the manufacturer (EmboCept ® S (PharmaCept) or Spherex ® (Magle Life Sciences)) [53]. In practice, the half-life ranges between 25 to 60 minutes [49,54,55]. The microspheres are degraded in vivo by plasma α-amylase into oligosaccharides, maltose, and eventually glucose that enters the normal metabolic cycle.…”

Section: Commercially Available Materialsmentioning

confidence: 99%

“…The hydrolyzable starch has a short half-life, minute scale, and the particles have very small diameters, averaging 50 μm, limiting clinical applications. The advancement of degradable embolics has been slower, but several labs are currently developing improved materials [49,110,111]. Treatment of uterine fibroids, for example, requires transient embolization of the uterine artery, particularly in patients who want to remain fertile.…”

Section: Research and Development Of Advanced Materialsmentioning

confidence: 99%

“…have synthesized poly(ethylene glycol) methacrylate (PEGMA) hydrolyzable microspheres for predictable transient embolization that require several hours as compared to minutes to degrade [49,113]. These microspheres were prepared using a suspension polymerization process of poly(lactide- co -glycolide)-poly(ethylene glycol) crosslinker and PEGMA monomer.…”

Section: Research and Development Of Advanced Materialsmentioning

confidence: 99%

See 3 more Smart Citations

Polymeric materials for embolic and chemoembolic applications

Poursaid

Jensen

Huo

et al. 2016

Journal of Controlled Release

111

102

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Percutaneous transcatheter embolization procedures involve the selective occlusion of blood vessels. Occlusive agents, referred to as embolics, vary in material characteristics including chemical composition, mechanical properties, and the ability to concurrently deliver drugs. Commercially available polymeric embolics range from gelatin foam to synthetic polymers such as poly(vinyl alcohol). Current systems under investigation include tunable, bioresorbable microspheres composed of chitosan or poly(ethylene glycol) derivatives, in situ gelling liquid embolics with improved safety profiles, and radiopaque embolics that are trackable in vivo. This article reviews commercially available materials used for embolization as well as polymeric materials that are under investigation.

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Section: Commercially Available Materialsmentioning

confidence: 99%

Section: Commercially Available Materialsmentioning

confidence: 99%

Section: Research and Development Of Advanced Materialsmentioning

confidence: 99%

Section: Research and Development Of Advanced Materialsmentioning

confidence: 99%

See 2 more Smart Citations

Polymeric materials for embolic and chemoembolic applications

Poursaid

Jensen

Huo

et al. 2016

Journal of Controlled Release

111

102

View full text Add to dashboard Cite

show abstract

“…properties, it is of special importance that both polymers possess non-immunogeneity and bioand blood compatibility (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). For all these reasons, it is expected that the integration of these two types of polymer segments into one macromolecule may lead to a variety of new application possibilities.…”

Section: Refs 1-29 and References Therein) In Addition To Their Intmentioning

confidence: 99%

Synthesis of Poly(methyl methacrylate)-poly(poly(ethylene glycol) methacrylate)-polyisobutylene ABCBA Pentablock Copolymers by Combining Quasiliving Carbocationic and Atom Transfer Radical Polymerizations and Characterization Thereof

Szabó¹,

Wacha²,

Thomann³

et al. 2015

Journal of Macromolecular Science, Part A

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Review of the Development of Methods for Characterization of Microspheres for Use in Embolotherapy: Translating Bench to Cathlab

Caine

Carugo

Zhang

et al. 2017

Adv Healthcare Materials

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Microspheres in Advanced Healthcare ApplicationsMicrospheres are small spherical particles with a diameter in the range 1-1000 µm, typically free-flowing in nature that can be made from either synthetic or natural materials (or a combination thereof). They have found widespread use in healthcare applications because numerous methods exist to manufacture Therapeutic embolotherapy is the deliberate occlusion of a blood vessel within the body, which can be for the prevention of internal bleeding, stemming of flow through an arteriovenous malformation, or occlusion of blood vessels feeding a tumor. This is achieved using a wide selection of embolic devices such as balloons, coils, gels, glues, and particles. Particulate embolization is often favored for blocking smaller vessels, particularly within hypervascularized tumors, as they are available in calibrated sizes and can be delivered distally via microcatheters for precise occlusion with associated locoregional drug delivery. Embolic performance has been traditionally evaluated using animal models, but with increasing interest in the 3R's (replacement, reduction, refinement), manufacturers, regulators, and clinicians have shown interest in the development of more sophisticated in vitro methods for evaluation and prediction of in vivo performance. Herein the current progress in developing bespoke techniques incorporating physical handling, fluid dynamics, occlusive behavior, and sustained drug elution kinetics within vascular systems is reviewed. While it is necessary to continue to validate the safety of such devices in vivo, great strides have been made in the development of bench tests that better predict the behavior of these products aligned with the principles of the 3R's.

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Poly(ethylene glycol) methacrylate hydrolyzable microspheres for transient vascular embolization

Cited by 45 publications

References 39 publications

Polymeric materials for embolic and chemoembolic applications

Polymeric materials for embolic and chemoembolic applications

Synthesis of Poly(methyl methacrylate)-poly(poly(ethylene glycol) methacrylate)-polyisobutylene ABCBA Pentablock Copolymers by Combining Quasiliving Carbocationic and Atom Transfer Radical Polymerizations and Characterization Thereof

Review of the Development of Methods for Characterization of Microspheres for Use in Embolotherapy: Translating Bench to Cathlab

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