‘Poly(ethylene glycol)-magnetic nanoparticles-curcumin’ trio: Directed morphogenesis and synergistic free-radical scavenging

Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI)

“…In curcumin conjugated MNPs, however, the peaks at 1628, 1603, 1429 and 1376 cm À1 were diminished, and a strong peak at 1654 cm À1 appeared, representing a conjugated C]O bond [50,61,62]. The OeH peak broadened and shifted to 3422, meaning that more hydroxyl bonds formed in the conjugated product, while the enolic (COH) peaks were not found, consistent with the C]O 1752 cm À1 for PLA, and CeOeC at 1094 cm À1 for PEG.…”

“…The enolic and dione groups of curcumin participated in forming a C]O conjugated bond with MNPs (Fig. 2C) [50]. Once curcumin bonds to MNPs, the MNPs become hydrophobic.…”

“…PEG in DMF was then added to 4% (mole ratio with iron oxide), and ultrasonication was resumed for another 3 min. The desired amount of curcumin was dissolved in DMF, added to the PEG-supported SPIO mixture, and sonicated for another 5 min [50]. The solution was then adjusted to a slightly acidic pH (~5.5) using ascorbic acid.…”

Interfacial tension of turmeric nanoparticles

“…Thus there is a limitation for its use as a therapeutic agent. Various techniques were proposed to improve the efficacy of curcumin, for example, micelle [6][7][8] , liposome 9 , microemulsion [10][11][12] , nanoemulsion 13,14 , nanoparticles 15,16 , nanocapsules [17][18][19] , self-assembling peptide hydrogel 20 , or solid lipid particle 21 . Microemulsion is a colloidal system of two immiscible liquids in which droplet formation requires low energy or occurs spontaneously 22 .…”

Enhanced antitumor activity of surface-modified iron oxide nanoparticles and an α-tocopherol derivative in a rat model of mammary gland carcinosarcoma

“…8 Coating should ensure colloidal stability of the particles in aqueous media, inhibit undesirable protein adsorption, and allow binding to drugs or other target biomolecules. Coatings of silica, 9 poly(ethylene glycol), 10 poly(vinyl alcohol), 11 polyvinylpyrrolidone, 12 poly(acrylic acid), 13 poly(methyl methacrylate), 14 chitosan, 15 dextran, 16 starch, 17 ethyl cellulose, 18 albumin, 19 and gelatin 20 have been described.…”