Poly(ethylene glycol)‐based poly(urethane isocyanurate) hydrogels for contact lens applications

Driest, Piet J.; Allijn, Iris E.; Dijkstra, Dirk J.; Stamatialis, Dimitrios; Grijpma, Dirk W.

doi:10.1002/pi.5938

Cited by 24 publications

(19 citation statements)

References 32 publications

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“…The PUI hydrogels developed in this work consist of chemical moieties that are known to be biocompatible or are expected to be biocompatible based on their chemical structure [34 , 42 , 43] . Also, comparable homopolymeric PEG-based PUI hydrogels have been shown to be biocompatible in indirect cytotoxicity studies [44] . Together with their water uptake, elastic moduli, ultimate tensile strength and toughness values in the water-swollen state, several of the new combinatorial PUI hydrogels are expected to be promising materials for biomedical applications.…”

Section: Potential Biomedical Applicationsmentioning

confidence: 99%

Tough combinatorial poly(urethane-isocyanurate) polymer networks and hydrogels synthesized by the trimerization of mixtures of NCO-prepolymers

et al. 2020

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The development of tough hydrogels is an essential but challenging topic in biomaterials research that has received much attention over the past years. By the combinatorial synthesis of polymer networks and hydrogels based on prepolymers with different properties, new materials with widely varying characteristics and unexpected properties may be identified. In this paper, we report on the properties of combinatorial poly(urethane-isocyanurate) (PUI) type polymer networks that were synthesized by the trimerization of mixtures of NCO-functionalized poly(ethylene glycol) (PEG), poly(propylene gylcol) (PPG), poly( ε-caprolactone) (PCL) and poly(trimethylene carbonate) (PTMC) prepolymers in solution. The resulting polymer networks showed widely varying material properties.Combinatorial PUI networks containing at least one hydrophilic PEG component showed high water uptakes of > 100 wt%. The resulting hydrogels demonstrated elastic moduli of up to 10.1 MPa, ultimate tensile strengths of up to 9.8 MPa, elongation at break values of up to 624.0% and toughness values of up to 53.4 MJ m −3 . These values are exceptionally high and show that combinatorial PUI hydrogels are among the toughest hydrogels reported in the literature. Also, the simple two-step synthesis and wide range of suitable starting materials make this synthesis method more versatile and widely applicable than the existing methods for synthesizing tough hydrogels. An important finding of this work is that the presence of a hydrophobic network component significantly enhances the toughness and tensile strength of the combinatorial PUI hydrogels in the hydrated state. This enhancement is the largest when the hydrophobic network component is crystallizable in nature. In fact, the PUI hydrogels containing a crystallizable hydrophobic network component are shown to be semi-crystalline in the water-swollen state. Due to their high toughness values in the water-swollen state together with their water uptake values, elastic moduli and ultimate tensile strengths, the developed hydrogels are expected to be promising materials for biomedical coating-and adhesive applications, as well as for tissue-engineering.

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Section: Potential Biomedical Applicationsmentioning

confidence: 99%

Tough combinatorial poly(urethane-isocyanurate) polymer networks and hydrogels synthesized by the trimerization of mixtures of NCO-prepolymers

et al. 2020

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“…However, the ultimate strength values were similar across all of the compositions, with nonsignificant differences. As described in our previous work [21] [43,44]. Such softening, mediated by water absorption, could provide advantages for medical applications [14].…”

Section: Mechanical Assessmentmentioning

confidence: 99%

Mechanical Assessment and Hyper-elastic Modeling of Polyurethanes for the Early Design of Vascular Graft

Arevalo¹,

Domínguez²,

Valero³

2020

Preprint

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The lack of suitable autologous grafts and poor compliance of existing prostheses have prompted the study of novel materials for vascular graft design. Polyurethanes (PUs) were used in the past because they have high compliance and properties that are similar to those of native tissue. In this work, the mechanical properties of a group of PUs in two states (non-hydrated and hydrated) were studied using uniaxial tensile tests, strain sweep tests, and multi-step creep recovery tests. Additionally, a hyper-elastic model based on the Mooney–Rivlin strain density function was fitted and used to model the performances of the PUs under physiological pressure and geometry conditions. The tensile tests revealed a softening phenomenon after hydration, which could potentially reduce patient discomfort and risk of vascular trauma. The ultimate strength values after hydration were similar to those reported for other vascular conduits. The strain sweep showed a strong strain dependency of the modulus indicating non-linear viscoelasticity. In the creep-recovery tests, increasing the polyethylene glycol(PEG) content enhanced the viscous flow, while the elastic behavior was enhanced with the largest concentration of polycaprolactone diol (PCL). On the other hand, under simulated physiological conditions, the compliance of the PUs showed a cyclic behavior with the time and pressure but was not affected by the radii and thickness variation, which could increase the graft compliance and geometry mismatch. Nevertheless, the compliance could be tuned using the material composition. This paper studied the biomechanics of a group of materials under simulated physiological conditions (Temperature, hydration, and pressure) to select those that could perform better for further vascular graft design.

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“…Moreover, the stimulus-responsive volume changes sensitive to temperature, pH, solvent, and electric field enables them to be applied in various biomedical applications [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. In addition, the excellent optical and mechanical properties of the hydrogels can be applied to multifunctional contact lenses [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Photoinitiated Polymerization of Hydrogels by Graphene Quantum Dots

et al. 2021

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As a smart stimulus-responsive material, hydrogel has been investigated extensively in many research fields. However, its mechanical brittleness and low strength have mattered, and conventional photoinitiators used during the polymerization steps exhibit high toxicity, which limits the use of hydrogels in the field of biomedical applications. Here, we address the dual functions of graphene quantum dots (GQDs), one to trigger the synthesis of hydrogel as photoinitiators and the other to improve the mechanical strength of the as-synthesized hydrogel. GQDs embedded in the network effectively generated radicals when exposed to sunlight, leading to the initiation of polymerization, and also played a significant role in improving the mechanical strength of the crosslinked chains. Thus, we expect that the resulting hydrogel incorporated with GQDs would enable a wide range of applications that require biocompatibility as well as higher mechanical strength, including novel hydrogel contact lenses and bioscaffolds for tissue engineering.

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Poly(ethylene glycol)‐based poly(urethane isocyanurate) hydrogels for contact lens applications

Cited by 24 publications

References 32 publications

Tough combinatorial poly(urethane-isocyanurate) polymer networks and hydrogels synthesized by the trimerization of mixtures of NCO-prepolymers

Tough combinatorial poly(urethane-isocyanurate) polymer networks and hydrogels synthesized by the trimerization of mixtures of NCO-prepolymers

Mechanical Assessment and Hyper-elastic Modeling of Polyurethanes for the Early Design of Vascular Graft

Photoinitiated Polymerization of Hydrogels by Graphene Quantum Dots

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