Poly epsilon-caprolactone nanoparticles containing a poorly soluble pesticide: formulation and stability study

Boehm, Alexander; Zerrouk, Robert; Fessi, Hatem

doi:10.1080/026520400288436

Cited by 52 publications

(1 citation statement)

References 10 publications

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“…According to the results in Table 2, the addition of surfactant did not reduce the particle size; on the contrary, the mean particle size significantly increased proportional to the concentration of PF68 for both polymer PCL and mePEG-PCL ( p < 0.05). Although it has been shown in literature that addition of surfactant causes increased solubility of polymer in aqueous media and decreases the particle size [60], the exact opposite of this situation has been found, too [61]. In our studies, the addition of surfactant for both nanoparticle formulations may have led to the formation of an extra surfactant layer and this layer increases the particle size.…”

Section: Resultsmentioning

confidence: 49%

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

Varan¹,

Bilensoy²

2017

Beilstein J. Nanotechnol.

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Background: Brain tumors are the most common tumors among adolescents. Although some chemotherapeutics are known to be effective against brain tumors based on cell culture studies, the same effect is not observed in clinical trials. For this reason, the development of drug delivery systems is important to treat brain tumors and prevent tumor recurrence. The aim of this study was to develop core–shell polymeric nanoparticles with positive charge by employing a chitosan coating. Additionally, an implantable formulation for the chemotherapeutic nanoparticles was developed as a bioadhesive film to be applied at the tumor site following surgical operation for brain glioma treatment. To obtain positively charged, implantable nanoparticles, the effects of preparation technique, chitosan coating concentration and presence of surfactants were evaluated to obtain optimal nanoparticles with a diameter of less than 100 nm and a net positive surface charge to facilitate cellular internalization of drug-loaded nanoparticles. Hydroxypropyl cellulose films were prepared to incorporate these nanoparticle dispersions to complete the implantable drug delivery system. Results: The diameter of core–shell nanoparticles were in the range of 70–270 nm, depending on the preparation technique, polymer type and coating. Moreover, the chitosan coating significantly altered the surface charge of the nanoparticles to net positive values of +30 to +50 mV. The model drug docetaxel was successfully loaded into all particles, and the drug release rate from the nanoparticles was slowed down to 48 h by dispersing the nanoparticles in a hydroxypropyl cellulose film. Cell culture studies revealed that docetaxel-loaded nanoparticles cause higher cytotoxicity compared to the free docetaxel solution in DMSO. Conclusion: Docetaxel-loaded nanoparticles dispersed in a bioadhesive film were shown to be suitable for application of chemotherapeutics directly to the action site during surgical operation. The system was found to release chemotherapeutics for several days at the tumor site and neighboring tissue. This can be suggested to result in a more effective brain tumor treatment when compared to chemotherapeutics administered as an intravenous bolus infusion.

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Section: Resultsmentioning

confidence: 49%

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

Varan¹,

Bilensoy²

2017

Beilstein J. Nanotechnol.

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Synthesis of Amphiphilic Copolymers of Poly(ethylene oxide) and Poly(ϵ‐caprolactone) with Different Architectures, and Their Role in the Preparation of Stealthy Nanoparticles

Rieger¹,

Passirani²,

Benoı̂t³

et al. 2006

Adv Funct Materials

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Well‐defined copolymers of biocompatible poly(ϵ‐caprolactone) (PCL) and poly(ethylene oxide) (PEO) are synthesized by two methods. Graft copolymers with a gradient structure are prepared by ring‐opening copolymerization of ϵ‐caprolactone (ϵCL) with a PEO macromonomer of the ϵCL‐type. The ϵCL polymerization is initiated by a PEO macroinitiator to prepare diblock copolymers. These amphiphilic copolymers are used as stabilizers for biodegradable poly(D,L‐lactide) (PLA) nanoparticles prepared by a nanoprecipitation technique. The effect of the copolymer characteristic features (architecture, composition, and amount) on the nanoparticle formation and structure is investigated. The average size, size distribution, and stability of aqueous suspensions of the nanoparticles is measured by dynamic light scattering. For comparison, an amphiphilic random copolymer, poly(methyl methacrylate‐co‐methacrylic acid) (P(MMA‐co‐MA)), is synthesized. The stealthiness of the nanoparticles is analyzed in relation to the copolymer used as stabilizer. For this purpose, the activation of the complement system by nanoparticles is investigated in vitro using human serum. This activation is much less important whenever the nanoparticles are stabilized by a PEO‐containing copolymer rather than by the P(MMA‐co‐MA) amphiphile. The graft copolymers with a gradient structure and the diblock copolymers with similar macromolecular characteristics (molecular weight and hydrophilicity) are compared on the basis of their capacity to coat PLA nanoparticles and to make them stealthy.

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Production of menthol‐loaded nanoparticles by solvent displacement

et al. 2017

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The production of menthol‐loaded poly‐ϵ‐caprolactone nanoparticles (NPs) for dermal application was investigated. The nanoparticles were produced in three different mixers: a confined impinging jet mixer (CIJM), a two‐inlet vortex mixer (VM), and a four‐inlet vortex mixer (MIVM), testing their performances in the same operating conditions. The effects of various process parameters such as polymer and menthol concentration, flow rate, solvent type (acetone, acetonitrile, or THF), and quench ratio, on mean nanoparticle size, menthol loading, and encapsulation efficiency were compared and discussed. The amount of menthol encapsulated inside the nanoparticles was quantified by GC analysis and the structure and shape of the NPs were analyzed by TEM. Nanoparticles of sizes between 200 nm to 800 nm were obtained using the CIJM, the VM, and the MIVM with different feeding sequences. It was observed that mixer geometry had a strong effect on particle size (at the same operating conditions the size decreased from MIVM with two inlets to VM and to CIJM) and the smallest particles were obtained using the MIVM using one solvent and three antisolvent streams. By using acetonitrile, the mean nanoparticle size was larger. Incorporation efficiency and menthol loading values up to 80 % and 60 % respectively were obtained depending on the inlet menthol and polymer concentrations.

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Poly epsilon-caprolactone nanoparticles containing a poorly soluble pesticide: formulation and stability study

Cited by 52 publications

References 10 publications

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

Synthesis of Amphiphilic Copolymers of Poly(ethylene oxide) and Poly(ϵ‐caprolactone) with Different Architectures, and Their Role in the Preparation of Stealthy Nanoparticles

Production of menthol‐loaded nanoparticles by solvent displacement

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