Poly(dopamine) coating of scaffolds for articular cartilage tissue engineering

Facile immobilization of heparin on bioabsorbable iron via mussel adhesive protein (MAPs)

“…Simply, in alkaline aqueous media, dopamine can undergo self-polymerization and produce strong adhesion PDA ad-layer on various materials including metal, polymer, and ceramic [11][12][13]. Moreover, this thin layer of PDA can not only promote cell adhesion and growth on several cell-resistant substrates [14], but also functionalize materials via Schiff-base reactions or Michael type reactions [15]. For example, immobilization of vascular endothelial growth factor (VEGF), antibacterial agents (quaternary ammonium salt, antimicrobial peptide, silver nana particles) [16,17], and cell-adhesive peptide RGD [18] on various biomaterials to improve their biocompatibility and antibacterial property have been reported.…”

Flexible fiber-reinforced composites with improved interfacial adhesion by mussel-inspired polydopamine and poly(methyl methacrylate) coating

“…Briefly, substrates are simply soaked in a DA aqueous solution at room temperature, and a polydopamine (PDA) layer on the substrate surface is readily formed via the oxidative polymerization of DA [18]. Various substrates including hydroxyapatite, carbon nanotube, glass, polytetraethylene (PTFE), polyester, silicon rubber, etc., have all been surface-coated with PDA in a similar manner [19][20][21][22][23][24][25][26][27]. The method would not ruin any structure of the original substrate, and it is extremely useful for biomedical applications because it does not require the time-consuming synthesis of complex linkers and the process is solvent-free and nontoxic.…”

In vitro response to alkaline phosphatase coatings immobilized onto titanium implants using electrospray deposition or polydopamine‐assisted deposition

“…9 Recently, we showed that a novel one-step polydopamineassisted immobilization procedure was even more effective in biomolecule immobilization than the conventional twostep procedure under certain experimental conditions by polymerizing dopamine in aqueous solutions containing biomolecules of interest. 9,16 The enzyme ALP plays an important role in physiological mineralization of bone tissue by catalysing organic phosphate hydrolysis, which in turn increases the phosphate concentration to supraphysiological levels that lead to calcium phosphate mineral formation. 18 Consequently, ALP was selected as the biomolecule of interest for the current study.…”

“…We hypothesized that different immobilization techniques (covalent vs. noncovalent bonding of ALP using polydopamine and ESD, respectively) would lead to different surface properties, including enzymatic activity of the immobilized ALP and wettability. In view of earlier reported effects of polydopamine on various surfaces [14][15][16] and effects of ALP on mineralization, 22,23 we further hypothesized that polydopamine-containing surface modifications would enhance the early attachment of cells, whereas ALP-containing surface modifications would accelerate mineralization.…”