Poly(dopamine) coating of 3D printed poly(lactic acid) scaffolds for bone tissue engineering

Kao, Chia Tze; Lin, Chun-Liang; Chen, Yi Wen; Yeh, Chia Hung; Fang, Hsin Yuan; Shie, Ming‐You

doi:10.1016/j.msec.2015.06.028

Cited by 275 publications

(166 citation statements)

References 44 publications

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“…The mussel adhesive-inspired polydopamine (PD) appears to be an ideal biomaterial coating since it fulfils all these criteria. It exhibits low cytotoxicity [2], antibacterial properties [3,4], promotes cell growth [5][6][7][8], resists corrosion [9], can aid antibiotic release [10,11], is simple to produce with control over film thickness [12] and can be attached to a variety of surfaces including silanes [13], metals [9,14], polymers [7,[15][16][17] dentine [18] and even hair [19].…”

Section: Introductionmentioning

confidence: 99%

“…PCL fibres have been coated with PD and investigated for use as bone tissue scaffolds [39], and 3D-printed scaffolds of PCL have been coated with PD resulting in an improvement in cell density versus control [17]. PLLA can be used for tendon repair [40], as a coating for stents [41] or made into scaffolds and coated with PD which improved adhesion and cell proliferation [7,42]. PHEMA has uses as a tissue engineering scaffold, sometimes as a hydrogel [38], and for the immobilisation of proteins [43].…”

Section: Introductionmentioning

confidence: 99%

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Probing polydopamine adhesion to protein and polymer films: microscopic and spectroscopic evaluation

2017

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Polydopamine has been found to be a biocompatible polymer capable of supporting cell growth and attachment, and to have antibacterial and antifouling properties. Together with its ease of manufacture and application, it ought to make an ideal biomaterial and function well as a coating for implants. In this paper, atomic force microscope was used to measure the adhesive forces between polymer-, protein-or polydopamine-coated surfaces and a silicon nitride or polydopamine-functionalised probes. Surfaces were further characterised by contact angle goniometry, and solutions by circular dichroism. Polydopamine was further characterised with infrared spectroscopy and Raman spectroscopy. It was found that polydopamine functionalisation of the atomic force microscope probe significantly reduced adhesion to all tested surfaces. For example, adhesion to mica fell from 0.27 ± 0.7 to 0.05 ± 0.01 nN nm -1 . The results suggest that polydopamine coatings are suitable to be used for a variety of biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Probing polydopamine adhesion to protein and polymer films: microscopic and spectroscopic evaluation

2017

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“…Cho et al 79 reported that polydopamine coating of the surface of polyethylene glycol adipate and polystyrene substrates could promote the proliferation and spreading of human neural stem cells. She et al 80 reported that polydopamine coating of polylactic acid scaffold surfaces increased the adhesion, proliferation, and differentiation of human AD-MSCs. Polydopamine can adsorb ECM proteins, such as fibronectin and collagen, providing a favorable environment for cell proliferation and spreading.…”

Section: Discussionmentioning

confidence: 99%

A collagen based cryogel bioscaffold coated with nanostructured polydopamine as a platform for mesenchymal stem cell therapy

Razavi

Thakor

2018

J Biomedical Materials Res

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Cryo-hydrogels (cryogels) are polymer hydrogels formed at sub-zero temperatures. Bioscaffolds created from cryo-gels have interconnected macropores which allow for cell migration, tissue-ingrowth, unhindered diffusion of solutes and mass transport of therapeutics. In this study, we developed collagen based cryogel bioscaffolds and coated them with polydopamine using a simple two-step technique. Cryogel bioscaffolds were synthesized by collagen crosslinking at −20°C and exhibited a macroporous interconnected architecture with 75% ± 63% porosity. Two groups of pore sizes were observed: 300 ± 50 μm and 30 ± 10 μm in diameter. The addition of a polydopamine coating to cryogel bioscaffolds was confirmed using composition analysis. This resulted in a 41% ± 6 5% decrease in water uptake, 81% ± 10% decrease in swelling rate and 12% ± 3% decrease in their degree of dissolution (p < 0.05), with a 48% ± 2% increase in stiffness and 57% ± 5% increase in compressive strength (p < 0.05). Seeding adipose tissue-derived mesenchymal stem cells (AD-MSCs) into polydopamine coated-cryogel bioscaffolds resulted in cells demonstrating a 52% ± 4% increase in viability and 33% ±3% increase in proliferation when compared to ADMSCs seeded into uncoated-cryogel bioscaffolds (p < 0.05). In summary, our novel polydopamine coated-cryogel bioscaffold represents an efficient and low-cost bioscaffold platform to support MSC therapies.

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“…The use of a small-animal model of mandibular defects allows investigation of the potential for union of transplanted scaffolding with natural bone, within a site of segmental defect. Similarly, Kao et al demonstrated that coating of 3D-printed PLA with bioinspired synthetic coatings increased the adhesion, proliferation, as well as the osteogenic and endothelial differentiation of ASCs in 3D structures [65]. These simple modifications to syn- Strategies for bioengineered scaffolds that support adipose stem cells in regenerative therapies Review thetic 3D-printed scaffolds may serve as the basis for effective delivery carriers in bone tissue engineering.…”

Section: Ascs In Synthetic Scaffolds For Osteogenic Therapeuticsmentioning

confidence: 98%

Strategies for Bioengineered Scaffolds that Support Adipose Stem Cells in Regenerative Therapies

et al. 2016

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Regenerative medicine possesses the potential to ameliorate damage to tissue that results from a vast range of conditions, including traumatic injury, tumor resection and inherited tissue defects. Adult stem cells, while more limited in their potential than pluripotent stem cells, are still capable of differentiating into numerous lineages and provide feasible allogeneic and autologous treatment options for many conditions. Adipose stem cells are one of the most abundant types of stem cell in the adult human. Here, we review recent advances in the development of synthetic scaffolding systems used in concert with adipose stem cells and assess their potential use for clinical applications.

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Poly(dopamine) coating of 3D printed poly(lactic acid) scaffolds for bone tissue engineering

Cited by 275 publications

References 44 publications

Probing polydopamine adhesion to protein and polymer films: microscopic and spectroscopic evaluation

Probing polydopamine adhesion to protein and polymer films: microscopic and spectroscopic evaluation

A collagen based cryogel bioscaffold coated with nanostructured polydopamine as a platform for mesenchymal stem cell therapy

Strategies for Bioengineered Scaffolds that Support Adipose Stem Cells in Regenerative Therapies

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