Poly(citric acid)-block-poly(ethylene glycol) copolymers—new biocompatible hybrid materials for nanomedicine

Naeini, Ashkan Tavakoli; Adeli, Mohsen; Vossoughi, Manouchehr

doi:10.1016/j.nano.2009.11.008

Cited by 86 publications

(53 citation statements)

References 31 publications

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“…sediments [2,3]. Nowadays, citric acid is also increasingly utilized as a monomer for the manufacture of biodegradable polymers which are widely used in various medical applications [4][5][6][7]. Due to its numerous applications and its generally recognized as safe (GRAS) nature, global production of citric acid has reached 1.7 million tonnes per year as estimated by Business Communications Co. (BCC, http://www.bccresearch.com) and is increasing at annual growth rate of 5% due to the possibility of expanding utilization of citric acid in biomedicine, biopolymer production and various other applications.…”

Section: Introductionmentioning

confidence: 99%

Utilization of different agro-industrial wastes for sustainable bioproduction of citric acid by Aspergillus niger

Dhillon

Brar

Verma

et al. 2011

Biochemical Engineering Journal

102

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Section: Introductionmentioning

confidence: 99%

Utilization of different agro-industrial wastes for sustainable bioproduction of citric acid by Aspergillus niger

Dhillon

Brar

Verma

et al. 2011

Biochemical Engineering Journal

102

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“…Similar structures have been reported previously by the reaction of polyethylene glycol and excess amounts of citric acid molecules. [33] The condensation reaction occurs between terminal hydroxyl groups of polycaprolactone chains and carboxylic acid group of citric acid molecules. Therefore, polycaprolactone chain bears two citric acid units at the chain ends, containing carboxylic acid functional groups.…”

Section: Resultsmentioning

confidence: 99%

Polymer–metal complex nanoparticles-containing cisplatin and amphiphilic block copolymer for anticancer drug delivery

Gheybi

Niknejad

Entezami

2013

Designed Monomers and Polymers

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Polymer-metal complex nanoparticles-containing cisplatin (cis-dichlorodiammineplatinum(II)), an anticancer drug, was prepared by a ligand-exchange reaction of cisplatin with core-shell-type poly(citric acid)-b-poly(caprolactone)-b-poly(citric acid) (PCA-PCL-PCA). The resulting polymer-platinum complex nanoparticles showed a high loading capacity (up to 44.2% w/w). The TEM observation confirmed that the nanoparticles with spherical shape were formed by the mixing of PCA-PCL-PCA copolymer and cisplatin. According to TEM and DLS, polymer-cisplatin complex nanoparticles showed larger diameters compared with empty block copolymer attributed to some intermolecular crosslinkings through polymer-platinum (II) complex formation. The release profile of the platinum (II) complexes in phosphate-buffered saline medium at 37°C indicated sustained manner of drug release. In vitro cytotoxicity evaluated by MTT assay, demonstrated that the PCA-PCL-PCA block copolymer does not exhibit apparent cytotoxicity. PCA-PCL-PCA-cisplatin complex nanoparticles showed greater cytotoxicity to HeLa cell line contrasted with free cisplatin, attributed to existence of poly (citric acid) moiety.

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“…Size and shape of molecular self-assemblies depend on the size of PCA block. 64 In another work photodegradable supramolecular systems were synthesized through the interaction of PCA-PEG-PCA, TiO 2 and indoxacarb pesticide. Under UV or natural light irradiation supramolecular system has been degraded 95 due to photocatalytic activity of TiO 2 nanoparticles.…”

Section: Dendritic Polymersmentioning

confidence: 99%

Polyamidoamine and polyglycerol; their linear, dendritic and linear–dendritic architectures as anticancer drug delivery systems

2015

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Despite immense investigations in the field of cancer diagnosis and therapy in recent decades, cancer is still the major cause of morbidity and mortality all over the world. Recently, with the advancement of nanotechnology, designing and preparation of efficient nano-sized structures having the potential of diagnosis and treatment of cancer have been proposed. Among different types of nano-sized materials, biocompatible polymers are seemed to be innovative tools with huge potential in cancer treatment. Advancement in polymer chemistry 10 55 gene delivery 2-7 , cancer diagnosis and therapy 8-11 , nanocarriers 12, 13 , nanomedicine 14-16 , and biomedical applications.

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Poly(citric acid)-block-poly(ethylene glycol) copolymers—new biocompatible hybrid materials for nanomedicine

Cited by 86 publications

References 31 publications

Utilization of different agro-industrial wastes for sustainable bioproduction of citric acid by Aspergillus niger

Utilization of different agro-industrial wastes for sustainable bioproduction of citric acid by Aspergillus niger

Polymer–metal complex nanoparticles-containing cisplatin and amphiphilic block copolymer for anticancer drug delivery

Polyamidoamine and polyglycerol; their linear, dendritic and linear–dendritic architectures as anticancer drug delivery systems

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