Poly(carboxylic acid) polymers as carriers for anthracyclines

Polymeric Micelles in Targeted Drug Delivery

“…Generally, in conventional synthetic polymer-drug conjugate systems and antibody-drug conjugate systems, a loss of the carrier's water solubility resulting from the conjugation of a hydrophobic drug creates a serious problem. Several research groups reported this problem of the polymer-drug conjugates in syntheses [110][111][112] and in their intravenous injections [113]. (d) Polymeric micelles can incorporate a large number of hydrophobic drug molecules in the micelles' inner core, and simultaneously, the micelles can maintain their water solubility by inhibiting intermicellar aggregation of the hydrophobic cores with a hydrophilic outer shell layer that works as a barrier against intermicellar aggregation.…”

Enzymatically Synthesized Pegylated Polymers as Nanomicellar Drug Delivery Systems

“…The two hydroxyl end groups of PEGs have been suitably fiinctionalized prior to coupling (14) with ligands of biological relevance, although the hydroxyl groups themselves have been used as well (15)(16)(17)(18). Because the number of terminal groups of linear PEGs (only two) to attach with drugs limits their drug loading capacity, extensive work has been done to functionalize them by copolymerizing PEGs with various functional monomers.…”

Synthesis and Characterization of Novel Poly(ethylene glycol) Based Amphiphilic Polymers

“…The two hydroxylend groups of PEG have been suitably functionalized prior to coupling (6) with ligands of biological relevance, although the hydroxyl groups themselves have been used as well (7)(8)(9). Because the number of terminal groups of PEGs (only two) to attach with drug limits their drug loading capacity, extensive work has been done to functionalize them by copolymerizing PEGs with various functional monomers.…”