Poly (Butylene Succinate)‐g‐Poly(Hydroxypropyl Methacrylate) as a New Meloxican Delivery System

Abstract

The use of biopolymer‐based drug delivery systems is increasing in the pharmaceutical area due to them biodegradable and biocompatible properties. In this work, a poly (butylene succinate) (PBS) grafted with poly (hydroxypropyl methacrylate) (PHPMA), PBSgPHPMA, is prepared using maleic unsaturations inserted in the PBS chain during its synthesis. Several characterization techniques are used to study the homopolymers and the grafted material. Among them, Fourier Transform Infrared (FTIR), Thermogravimetric analysis (TGA) Differential scanning calorimetry (DSC), and X‐ray diffraction (XRD) allowed inferring the obtaining of the aimed materials. Also, the copolymer is used to prepare microparticles containing Meloxicam by emulsification and solvent evaporation method. These microparticles are tested as drug delivery systems under pH 8.5 (gastrointestinal) and pH 5.5 (skin). The primary results allowed inferring that the grafted material can be used as a drug delivery system, showing that the release rate at pH 5.5 allowed the slower delivery rate among tested materials.

Poly(Butylene Succinate) Molar Mass Calculation by GPC and 1H‐NMR

“…It is a biodegradable polyester whose production by renewable sources is cheaper than its production by oil derivates. [7][8][9][10][11][12][13][14] Its synthesis can be performed by the polycondensation of 1,4-butanediol and succinic acid/anhydride using a range of different catalysts. [15] Besides, PBS presents similar thermal and mechanical properties to low-density polyethylene and polypropylene, which makes its commercial application viable.…”

Geopolymer Microparticles as Up‐and‐Coming H2S Sorbers

“…Nowadays, the search for high‐performance, environmentally friendly, and low‐cost materials is constantly advancing. [ 7–114 ] According to Google Scholar, during the last decade (2010–2020), 1310000 articles were published in the area of high‐performance materials. They include high‐performance materials produced with polymers, with 12,5000 articles registered.…”

A Bio-Phase Change Material from Poly(butylene succinate) to be used in Concrete

“…Bio-PCMs are already studied to act improving the thermal properties of concrete, as found by Olawoore (8). It is biodegradable and its production is cheaper than its oil derivate counterparts, even though it is produced using renewable sources (10)(11)(12)(13)(14)(15)(16)(17). It can be produced by polycondensation of 1,4-butanediol and succinic acid/anhydride using many different catalysts (18).…”