Poly amino acid thermosensitive hydrogel loaded with ICG-001 for inhibiting keloid by down-regulating the Wnt/β-Catenin pathway

Sheng, Fan; Luo, Yinli; Wu, Di; Yuan, Jiachen; Zheng, Gengfeng; Zheng, Yuhao; Jin, Zhehu

doi:10.1016/j.matdes.2022.111050

Cited by 4 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Local injections of hydrogels offer an attractive approach because they can be given without intravenous injection, providing a more sustained release and high dose of therapeutic agents at the lesion, preventing prolonged blood circulation, and reducing side effects on normal tissues. LA67-RL-Gel gels were faster at 37 °C compared to the our team’s previous studies [ 31 ].…”

Section: Discussionmentioning

confidence: 71%

“…Keloids are a skin disease that cause life and mental stress to patients due to their severe aesthetic impact, characterized by excessive proliferation of fibroblasts and deposition of extracellular matrix leading to fibrosis [ 31 ]. This study aimed to explore an RGD-modified LNP hydrogel loaded with LA67 for treating keloids by peritumoral injection.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

LA67 Liposome-Loaded Thermo-Sensitive Hydrogel with Active Targeting for Efficient Treatment of Keloid via Peritumoral Injection

Wan,

Wang,

et al. 2023

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

A keloid is a benign tumor manifested as abnormal fibroplasia on the surface of the skin. Curing keloids has become a major clinical challenge, and searching for new treatments and medications has become critical. In this study, we developed a LA67 liposome-loaded thermo-sensitive hydrogel (LA67-RL-Gel) with active targeting for treating keloids via peritumoral injection and explored the anti-keloid mechanism. Firstly, Arg-Gly-Asp (RGD) peptide-modified liposomes (LA67-RL) loaded with LA67 were prepared with a particle size of 105.9 nm and a Zeta potential of −27.4 mV, and an encapsulation efficiency of 89.6 ± 3.7%. We then constructed a thermo-sensitive hydrogel loaded with LA67-RL by poloxamer 407 and 188. The formulation was optimized through the Box–Behnken design, where the impact of the proportion of the ingredients on the quality of the hydrogel was evaluated entirely. The optimal formulation was 20.7% P407 and 2.1% P188, and the gelation time at 37 °C was 9.5 s. LA67-RL-Gel slowly released 92.2 ± 0.8% of LA67 at pH 6.5 PBS for 72 h. LA67-RL-Gel increased adhesion with KF cells; increased uptake; promoted KF cells apoptosis; inhibited cell proliferation; reduced α-SMA content; decreased collagen I, collagen III, and fibronectin deposition; inhibited angiogenesis; and modulated the keloid microenvironment, ultimately exerting anti-keloid effects. In summary, this simple, low-cost, and highly effective anti-keloid liposome hydrogel provides a novel approach for treating keloids and deserves further development.

show abstract

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

LA67 Liposome-Loaded Thermo-Sensitive Hydrogel with Active Targeting for Efficient Treatment of Keloid via Peritumoral Injection

Wan,

Wang,

et al. 2023

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Photothermal antibacterial properties combined with YAP inhibition [131] TGF-β/smad pathway TGF-β inhibitor loaded PLGA microcapsules. Timed pulsatile release of inhibitors [93] ZnO-curcumin Regulating angiogenesis and TGF-β3 expression [145] Silver-Catechin Nanocomposite Down-regulation of the TGF-β1 and upregulation TGF-β3 expression [48] TGF-βRI siRNA Delivery with UCNPs@mSiO 2 Silencing of TGF-βRI expression and suppressing CTGF mRNA expression [124] IntegrinÀFAK pathway Drug-free silk fibroin MN MNs interrupting the mechanical communication between fibroblasts and the ECM [123] Wnt/β-Catenin pathway ICG-001 Down-regulating the Wnt/β-Catenin pathway [57] Cyclodextrin metal-organic framework (CDF) containing quercetin Downregulating the Wnt/β-catenin and JAK2/ STAT3 pathways [127] SPARC Gelatin-Tyramine-siSPARC nanoplex reduction in SPARC gene expression and collagen production [125] development to overcome current challenges and realize the full potential of these technologies in clinical practice. The goal of achieving scarless wound healing remains a key focus, with in-depth study in nanotechnology and biological mechanism in HS playing a crucial role in this pursuit.…”

Section: Discussionmentioning

confidence: 99%

“…migration, and invasion of HS fibroblasts, and induces apoptosis in these cells by reducing alpha smooth muscle actin (α-SMA), collagen-I, collagen-III, platelet-derived growth factor (PDGF), and tissue inhibitor of metalloproteinase-1 (TIMP-1) proteins. [57] 3. Nano-Based Delivery Systems Numerous clinical drugs have long been used for HS therapy.…”

Section: Regulation Of Fibroblast Apoptosismentioning

confidence: 99%

Advances of Nanobiomaterials for Treating Skin Pathological Fibrosis

Kang,

Liu,

Chen

et al. 2024

Advanced NanoBiomed Research

View full text Add to dashboard Cite

Skin pathological fibrosis conditions, such as hypertrophic scars (HS) and keloids, where the scar tissue is raised and extends beyond the original wound boundary, are aesthetically unappealing and sometimes painful or itchy, significantly impacting the life quality of patients. In this review, the advances of nanobiomaterials in treating skin pathological fibrosis are summarized and discussed. The focus is on the therapeutic approaches to cellular and molecular targets of HS, highlighting the potential of nanotechnology in scar management. The biofunctional nanomaterials can modulate inflammation, regulate angiogenesis, and promote fibroblast apoptosis. The nanotechnology‐based drug delivery systems such as liposomes, ethosomes, and dendritic macromolecules can improve the solubility, stability, and efficacy of drugs, and enhance precise delivery, resulting in better outcomes in HS therapy. Integrating nanomaterials or nanostructures into hydrogels, nanofibers, and microneedles can enhance the biological functionality and maximize the therapeutic effect of nanoparticles (NPs) at the wound site. The important potential of nanotechnology‐based scar treatment should be further explored to overcome the current challenges and promote its application in clinical practice.

show abstract

Synthesis and in vitro study of biodegradable and thermoresponsive polymer based on polysuccinimide for drug delivery

Trinh,

Kang,

Lee

et al. 2024

European Polymer Journal

View full text Add to dashboard Cite

Poly amino acid thermosensitive hydrogel loaded with ICG-001 for inhibiting keloid by down-regulating the Wnt/β-Catenin pathway

Cited by 4 publications

References 29 publications

LA67 Liposome-Loaded Thermo-Sensitive Hydrogel with Active Targeting for Efficient Treatment of Keloid via Peritumoral Injection

LA67 Liposome-Loaded Thermo-Sensitive Hydrogel with Active Targeting for Efficient Treatment of Keloid via Peritumoral Injection

Advances of Nanobiomaterials for Treating Skin Pathological Fibrosis

Synthesis and in vitro study of biodegradable and thermoresponsive polymer based on polysuccinimide for drug delivery

Contact Info

Product

Resources

About