Poly(Amino Acid) Nanoparticles as a Promising Tool for Anticancer Therapeutics

Abdelaziz, Hadeer M.; Abdelmoneem, Mona A.; Abd-Elsalam, Kholod; Freag, May S.; Elkhodairy, Kadria A.; Elzoghby, Ahmed O.

doi:10.1016/b978-0-12-816963-6.00009-1

Cited by 2 publications

(1 citation statement)

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“…For that reason, Poly(L-histidine) is a promising pH-sensitive polymer with excellent biodegradability, biocompatibility, and fusogenic activity [ 286 ]. In fact, when the environment is below pH 6, PLH turns positively charged and hydrophilic, causing the rupture of the endosomal membrane and facilitating the endosomal escape via the so-called proton sponge effect [ 287 , 288 ].…”

Section: Functionalization Of Msns With Biopolymersmentioning

confidence: 99%

Natural Biopolymers as Smart Coating Materials of Mesoporous Silica Nanoparticles for Drug Delivery

et al. 2023

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In recent years, the functionalization of mesoporous silica nanoparticles (MSNs) with different types of responsive pore gatekeepers have shown great potential for the formulation of drug delivery systems (DDS) with minimal premature leakage and site-specific controlled release. New nanotechnological approaches have been developed with the objective of utilizing natural biopolymers as smart materials in drug delivery applications. Natural biopolymers are sensitive to various physicochemical and biological stimuli and are endowed with intrinsic biodegradability, biocompatibility, and low immunogenicity. Their use as biocompatible smart coatings has extensively been investigated in the last few years. This review summarizes the MSNs coating procedures with natural polysaccharides and protein-based biopolymers, focusing on their application as responsive materials to endogenous stimuli. Biopolymer-coated MSNs, which conjugate the nanocarrier features of mesoporous silica with the biocompatibility and controlled delivery provided by natural coatings, have shown promising therapeutic outcomes and the potential to emerge as valuable candidates for the selective treatment of various diseases.

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Section: Functionalization Of Msns With Biopolymersmentioning

confidence: 99%