Poly(alkylene H-phosphonate)s

Troev, K.

doi:10.1016/b978-0-12-416036-1.00001-2

Cited by 14 publications

(19 citation statements)

References 196 publications

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“…PPEs are an interesting class of organophosphorus polymers, because the polymer backbone and phosphorus substituents can be modified to obtain new materials with several applications, as mentioned before (flame retardants industry, 10 biomedical applications, [11][12][13] drug delivery industry, 14 or tissue engineering). [15][16][17] These polymers can be prepared by the following methods:…”

Section: Methods To Obtain Ppesmentioning

confidence: 99%

“…These polymers, as shown in Fig. [2][3][4][5][6][7][8][9][10] During the last decades, the development of PPEs chemistry showed the possibility of obtaining PPEs with various structures. [2][3][4][5][6][7][8][9] Polyphosphates with P-O bonds are suitable for flameretardation applications.…”

Section: Introductionmentioning

confidence: 99%

“…The polyphosphates were obtained by different chemical processes, such as ROP, polycondensation, or polyaddition. [2][3][4][5][6][7][8][9][10] During the last decades, the development of PPEs chemistry showed the possibility of obtaining PPEs with various structures. The linear homo-or random-PPEs were the most studied, and they are still of great interest.…”

Section: Introductionmentioning

confidence: 99%

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The Use of Transesterification Method for Obtaining Phosphorus‐Containing Polymers

et al. 2014

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An introduction and overview of the transesterification method is presented in this review. This method is a very convenient way to obtain polyphosphoesters (PPEs). It can be simply described as a chemical reaction in which an ester is transformed into another one by the exchange of alkoxy groups. In this review, we will refer to the synthesis of PPEs via transesterification. In other words, it is focused on the applications of the transesterification method in phosphorus chemistry to obtain polymers (PPEs). The PPEs are an interesting class of organophosphorus polymers. These compounds are important for biological applications because of their biocompatibility and similarity to biopolymers. When the products are polymers, the chemical reaction is called polytransesterification. This method has also several applications in industry (esters of oil, paint industry). C

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Section: Methods To Obtain Ppesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Use of Transesterification Method for Obtaining Phosphorus‐Containing Polymers

et al. 2014

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“…11 A unique exception is the diverse family of poly(phosphoester)s (PPEs) which are (bio)degradable and are currently attracting interest in several research groups. [12][13][14] PPEs are accessible by different synthetic approaches, 15 namely polycondensation, polyaddition, transesterication and ring-opening polymerization (ROP) of cyclic phosphoesters. 14,16,17 ROP allows the controlled polymerization with adjustable molecular weights and narrow molecular weight distributions.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional poly(phosphoester)s with two orthogonal protective groups

2015

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“…[28][29][30] Besides, poly(hydroxyoxyethylene phosphate)s are biodegradable, biocompatible, water soluble and low toxic polymers. 31 Polyphosphoesters degraded through hydrolysis of the PAOAC ester bonds under acidic or basic conditions [31][32][33] and this can be particularly accelerated in the presence of phosphoesterase. [34][35][36] Chemotherapeutic agents possessing a phosphate unit would preferentially interact with the cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Polyphosphoester‐based paclitaxel complexes

Mitova

Hristova

Cherkezova

et al. 2015

J of Applied Polymer Sci

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We demonstrated a feasible approach for the preparation of a biodegradable, water soluble polyphosphoester based paclitaxel complex. Applying poly(hydroxyoxyethylene phosphate) which contains both a strong proton accepting PO group and a proton donating POH group, paclitaxel has been physically immobilized onto the polymer via H‐bonding. The water soluble complex contained 16.7 wt % paclitaxel and more than 4000 times increased drug solubility was achieved. The polymer‐drug complex formed nanosized aggregates that were characterized by dynamic light scattering. Intravenous injection of poly(hydroxyoxyethylene phosphate) in rats at a dose of 1000 mg/kg did not induce any clinical signs or body weight gain reduction. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42772.

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Poly(alkylene H-phosphonate)s

Cited by 14 publications

References 196 publications

The Use of Transesterification Method for Obtaining Phosphorus‐Containing Polymers

The Use of Transesterification Method for Obtaining Phosphorus‐Containing Polymers

Multifunctional poly(phosphoester)s with two orthogonal protective groups

Polyphosphoester‐based paclitaxel complexes

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