“…Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme, that catalyses a successive transfer of ADP-ribose moiety of NAD + to a protein, thus forming a protein, bound polymer of ADP-ribose [1]. Various nuclear proteins including histones [1], HMG proteins [2] and nuclear enzymes involved in DNA metabolism, such as Ca# + , Mg# + -dependent endonuclease [3,4], DNA topoisomerases [5,6], DNA ligase I [7,8], terminal deoxynucleotidyl transferase [9], DNA polymerases [8,10] and PARP itself (automodification ; [11,12]) have been shown to be the acceptors for poly(ADP-ribose).…”