Poly (ADP-ribose) polymerase-1 inhibitor, 3-aminobenzamide pretreatment ameliorates lipopolysaccharide-induced neurobehavioral and neurochemical anomalies in mice

Sriram, Chandra Shaker; Jangra, Ashok; Gurjar, Satendra Singh; Hussain, Iftikar; Borah, Probodh; Lahkar, Mangala; Mohan, Pritam; Bezbaruah, Babul Kumar

doi:10.1016/j.pbb.2015.03.022

Cited by 22 publications

(12 citation statements)

References 68 publications

(58 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This time point was considered because in our previous studies, anxiety-like behavior was found prominent in mice 3-h post-LPS injection [3,21]. LPS administration induced an anxiogenic effect as evident by reduction in the open arm time (P 0.001) and number of entries in the open arm (P 0.001) in EPM test when compared with vehicle-treated control group (Table 1).…”

Section: Effects Of Spb Pretreatment On Lps-induced Anxiety and Deprementioning

confidence: 98%

“…Sucrose preference test was performed during the 24-h interval following LPS administration. The time-point 3 and 24 h were considered for anxiety and depressive-like behavior assessment because previous studies suggested that the anxiety and depressive-like behavior peaks after 3 and 24 h, respectively, after the LPS administration [3,21,22]. Behavioral and biochemical tests were performed on different animals to avoid the possible influence of behavioral assessment on biochemical parameters.…”

Section: Animalsmentioning

confidence: 99%

“…ER stress-related transcripts were quantified using real-time PCR. Primers used f o r a m p l i f i c a t i o n w e r e G R P 7 8 : f o r w a r d 5 ′ -GTTTGCTGAGGAAGACAAAAAGCTC-3′ and reverse 5′-CACTTCCATAGAGTTTGCTGATAATTG-3′; CHOP: forward 5′-GGAGCTGGAAGCCTGGTATGAGG-3′ and reverse 5′-TCCCTGGTCAGGCGCTCGATTTCC-3′; and β-actin: forward 5′-TCCTCCCTGGAGAAGAGCTAC-3′ and reverse 5′-TCCTGCTTGCTGATCCACAT-3′ [21,31]. The relative gene expressions of GRP78 and CHOP were determined by the 2 −ΔΔCT method for real-time quantitative PCR.…”

Section: Determination Of Grp78 and Chop Mrna Level By Real-time Pcrmentioning

confidence: 99%

See 2 more Smart Citations

Lipopolysaccharide-Induced Behavioral Alterations Are Alleviated by Sodium Phenylbutyrate via Attenuation of Oxidative Stress and Neuroinflammatory Cascade

2016

Self Cite

View full text Add to dashboard Cite

Oxido-nitrosative stress, neuroinflammation, and reduced level of neurotrophins are implicated in the pathophysiology of anxiety and depressive illness. A few recent studies have revealed the role of endoplasmic reticulum (ER) stress in the pathophysiology of stress and depression. The aim of the present study is to investigate the neuroprotective potential of sodium phenylbutyrate (SPB), an ER stress inhibitor against lipopolysaccharide (LPS)-induced anxiety and depressive-like behavior in Swiss albino mice. Anxiety and depressive-like behavior was induced by LPS (0.83 mg/kg; i.p.) administration. Various behavioral tests were conducted to evaluate the anxiety and depressive-like behavior in mice. Real-time PCR was employed for the detection and expression of ER stress markers (78-kDa glucose-regulated protein (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP)). Pretreatment with SPB significantly ameliorated the LPS-induced anxiety and depressive-like behavior as revealed by behavioral paradigm results. LPS-induced oxidative stress was ameliorated by SPB pretreatment in hippocampus (HC) and prefrontal cortex (PFC) region. Neuroinflammation was significantly reduced by SPB pretreatment in LPS-treated mice as evident from reduction in proinflammatory cytokines (IL-1β and TNF-α). Importantly, LPS administration significantly up-regulated the GRP78 mRNA expression level in the HC which suggests the involvement of unfolded protein response (UPR) in LPS-evoked behavioral anomalies. These results highlight the neuroprotective potential of SPB in LPS-induced anxiety and depressive illness model which may be partially due to inhibition of oxidative stress-neuroinflammatory cascade.

show abstract

Section: Effects Of Spb Pretreatment On Lps-induced Anxiety and Deprementioning

confidence: 98%

Section: Animalsmentioning

confidence: 99%

Section: Determination Of Grp78 and Chop Mrna Level By Real-time Pcrmentioning

confidence: 99%

See 1 more Smart Citation

Lipopolysaccharide-Induced Behavioral Alterations Are Alleviated by Sodium Phenylbutyrate via Attenuation of Oxidative Stress and Neuroinflammatory Cascade

2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Additionally, PARP inhibition appeared to have an additive antidepressant effect when combined with fluoxetine [9]. PARP inhibitors have also been shown to protect rodents from helplessness behavior in inflammationinduced sickness behavior [19].…”

Section: Resultsmentioning

confidence: 99%

Rapid and temporary improvement of depression and anxiety observed following niraparib administration: a case report

Jewett

Miller

Ligon³

et al. 2020

BMC Psychiatry

View full text Add to dashboard Cite

Background: Cancer patients are disproportionately affected by generalized anxiety and major depression. For many, current treatments for these conditions are ineffective. In this case report, we present a serendipitous case of anxiety and depression improvement following administration of the poly (ADP-ribose) polymerase (PARP) inhibitor niraparib. Case presentation: A 61-year old woman with a 20-year history of mild depression developed recurrent ovarian carcinoma and was placed on niraparib for maintenance chemotherapy. With the original onset of ovarian cancer, she experienced an episode of major depression that was resolved with sertraline. After recurrence of ovarian cancer, she experienced a recurrence of major depression and a new onset of generalized anxiety that failed to completely respond to multiple medications. After beginning niraparib therapy the patient noticed a rapid resolution of the symptoms of her anxiety and depression, an effect that was limited to 10-14 days. Due to bone marrow suppression, the patient was taken off and restarted on niraparib several times. Each discontinuation of niraparib resulted in return of her depression and anxiety, while each recontinuation of niraparib resulted in an improvement in her mood and anxiety. Conclusions: This case demonstrates rapid and temporary improvement of anxiety and depression following niraparib administration. There is ample preclinical data that PARP signaling may play a role in psychiatric illness. A small amount of indirect data from clinical trials also shows that niraparib may have psychiatric benefits. Further research on PARP inhibition and its potential psychoactive effects is sorely needed.

show abstract

“…Furthermore, antidepressant effects of minocycline have been anecdotally observed in humans as well as in many studies using rodent models ( Molina-Hernández et al, 2008 ; O’Connor et al, 2009 ; Arakawa et al, 2012 ; Saeedi Saravi et al, 2016 ). In a study of inflammation and its behavioral consequences, treatment of rats with the PARP inhibitor 3-aminobenzamide (3-AB) reversed depressive effects caused by lipopolysaccharide injection ( Sriram et al, 2015 ). However, this sickness-based model for depression arguably remains etiologically distant from causes of MDD in humans ( Stepanichev et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-Like Actions of Inhibitors of Poly(ADP-Ribose) Polymerase in Rodent Models

Ordway

Szebeni

Hernandez

et al. 2017

International Journal of Neuropsychopharmacology

View full text Add to dashboard Cite

BackgroundMany patients suffering from depressive disorders are refractory to treatment with currently available antidepressant medications, while many more exhibit only a partial response. These factors drive research to discover new pharmacological approaches to treat depression. Numerous studies demonstrate evidence of inflammation and elevated oxidative stress in major depression. Recently, major depression has been shown to be associated with elevated levels of DNA oxidation in brain cells, accompanied by increased gene expression of the nuclear base excision repair enzyme, poly(ADP-ribose) polymerase-1. Given these findings and evidence that drugs that inhibit poly(ADP-ribose) polymerase-1 activity have antiinflammatory and neuroprotective properties, the present study was undertaken to examine the potential antidepressant properties of poly(ADP-ribose) polymerase inhibitors.MethodsTwo rodent models, the Porsolt swim test and repeated exposure to psychological stressors, were used to test the poly(ADP-ribose) polymerase inhibitor, 3-aminobenzamide, for potential antidepressant activity. Another poly(ADP-ribose) polymerase inhibitor, 5-aminoisoquinolinone, was also tested.ResultsPoly(ADP-ribose) polymerase inhibitors produced antidepressant-like effects in the Porsolt swim test, decreasing immobility time, and increasing latency to immobility, similar to the effects of fluoxetine. In addition, 3-aminobenzamide treatment increased sucrose preference and social interaction times relative to vehicle-treated control rats following repeated exposure to combined social defeat and unpredictable stress, mediating effects similar to fluoxetine treatment.ConclusionsThe poly(ADP-ribose) polymerase inhibitors 3-aminobenzamide and 5-aminoisoquinolinone exhibit antidepressant-like activity in 2 rodent stress models and uncover poly(ADP-ribose) polymerase as a unique molecular target for the potential development of a novel class of antidepressants.

show abstract

Poly (ADP-ribose) polymerase-1 inhibitor, 3-aminobenzamide pretreatment ameliorates lipopolysaccharide-induced neurobehavioral and neurochemical anomalies in mice

Cited by 22 publications

References 68 publications

Lipopolysaccharide-Induced Behavioral Alterations Are Alleviated by Sodium Phenylbutyrate via Attenuation of Oxidative Stress and Neuroinflammatory Cascade

Lipopolysaccharide-Induced Behavioral Alterations Are Alleviated by Sodium Phenylbutyrate via Attenuation of Oxidative Stress and Neuroinflammatory Cascade

Rapid and temporary improvement of depression and anxiety observed following niraparib administration: a case report

Antidepressant-Like Actions of Inhibitors of Poly(ADP-Ribose) Polymerase in Rodent Models

Contact Info

Product

Resources

About