Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death

Castedo, Maria; Lafarge, Antoine; Kroemer, Guido

doi:10.15698/cst2023.01.275

Cited by 2 publications

(1 citation statement)

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“…Nuclear DNA damage may lead to increased energy consumption, and therefore, the mitochondrial alterations may be secondary to faults in nuclear DNA repair and/or DNA damage [8,18]. Alterations in mitochondrial ATP production may be caused by the activation of PARP1, an enzyme that responds to DNA damage [19]. Activated PARP1 utilizes key metabolites which may attenuate pathways for the protection of cells.…”

Section: Parp1 Is Involved In the Pathogenesis Of Progeroid Syndromesmentioning

confidence: 99%

Roles of poly(ADP-ribose) polymerase 1 and mitophagy in progeroid syndromes as well as physiological ageing

Suga,

Ikeda,

Yoshikawa

et al. 2023

Exploration of Medicine

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Progeroid syndromes are characterized by clinical signs of premature ageing, which may contain several diseases such as Werner syndrome, Bloom syndrome, Rothmund-Thomson syndrome, Hutchinson-Gilford progeria syndrome, and Cockayne syndrome. These disorders may also exhibit some pathological involvements reminiscent of primary mitochondrial diseases. Emerging evidence has linked mitochondria even to physiological ageing. In addition, alterations in the maintenance pathway of mitochondria have been also deliberated as relevant in age-related diseases. In particular, mitophagy and its regulatory pathway might be key process for the homeostasis of mitochondria. Therefore, chronic DNA damage and/or the activation of poly[adenosine diphosphate (ADP)-ribose] polymerase 1 (PARP1) could be a threat to the mitochondrial alterations. The PARP1 is an enzyme responding to the DNA damage, which might be also involved in the mitophagy. Interestingly, the PARP1 has been reported to play an important role in the longevity of lifespan, which has attracted growing attention with the social development. This review may provide a rationalized overview of the involvement of mitochondrial oxidative stresses in genetically defined accelerated ageing, progeroid syndromes, physiological ageing, and/or age-related diseases for the innovative therapeutic approaches.

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Section: Parp1 Is Involved In the Pathogenesis Of Progeroid Syndromesmentioning

confidence: 99%