Poly(ADP-ribose)polymerase-1 affects hydroquinone-induced aberrant cell cycle and apoptosis through activation of p16/pRb signaling pathway in TK6 cells

Luo, Hao; Chen, Lin; Cui, Zheming; Du, Jinlin; Yang, Hui; Qiu, Weifeng; Zhai, Ling; Liang, Heng; Tang, Huanwen

doi:10.1016/j.ecoenv.2022.113259

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…Previous studies have demonstrated that JNK1 signaling pathway can participate in the cell cycle progression after HQ exposure 22 . In our current study, we observed that HQ could inhibit cell proliferation and activate JNK1 signaling pathway.…”

Section: Discussionsupporting

confidence: 65%

“…Previous studies have demonstrated that JNK1 signaling pathway can participate in the cell cycle progression after HQ exposure. 22 In our current study, we observed that HQ could inhibit cell proliferation and activate JNK1 signaling pathway. Meanwhile, we also demonstrated that HQ promoted the cell cycle progression and elevated CyclinE1, CDK4, p-Rb, E2F1, CyclinD1, and CDK2.…”

Section: Discussionmentioning

confidence: 49%

“…Inhibition of JNK activation blocks cyclin accumulation, resulting in the suspension of the mitotic process and cell proliferation 14 . In our previous study, we found that HQ induced S‐phase arrest and activated JNK1 signaling pathway in TK6 cells 22 . However, the exact mechanism of JNK1 involvement in HQ‐induced malignant transformation process in TK6 cells is not clear.…”

Section: Introductionmentioning

confidence: 99%

“…14 In our previous study, we found that HQ induced S-phase arrest and activated JNK1 signaling pathway in TK6 cells. 22 However, the exact mechanism of JNK1 involvement in HQ-induced malignant transformation process in TK6 cells is not clear.…”

mentioning

confidence: 99%

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JNK1 activated pRb/E2F1 and inhibited p53/p21 signaling pathway is involved in hydroquinone‐induced pathway malignant transformation of TK6 cells by accelerating the cell cycle progression

Qiu

Gao

et al. 2023

Environmental Toxicology

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Hydroquinone (HQ) is an important metabolites of benzene in the body, and it has been found to result in cellular DNA damage, mutation, cell cycle imbalance, and malignant transformation. The JNK1 signaling pathway plays an important role in DNA damage repair. In this study, we focused on whether the JNK1 signaling pathway is involved in the HQ‐induced cell cycle abnormalities and the underlying mechanism. The results showed that HQ induced abnormal progression of the cell cycle and initiated the JNK1 signaling pathway. We further confirmed that JNK1 suppression decelerated the cell cycle progression through inhibiting pRb/E2F1 signaling pathway and triggering p53/p21 pathway. Therefore, we concluded that JNK1 might be involved in HQ‐induced malignant transformation associated with activating pRb/E2F1 and inhibiting p53/p21 signaling pathway which resulting in accelerating the cell cycle progression.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 49%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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JNK1 activated pRb/E2F1 and inhibited p53/p21 signaling pathway is involved in hydroquinone‐induced pathway malignant transformation of TK6 cells by accelerating the cell cycle progression

Qiu

Gao

et al. 2023

Environmental Toxicology

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“…Previous studies have demonstrated that PARP primarily governed the detection of DNA damage and the initiation of DDR [57] , and the cleavage of PARP has been considered as the evidence of caspase activation and apoptosis [58] . γ-H2AX, a sensitive marker of DSBs, is the first step in recruiting and locating DDR proteins.…”

Section: Discussionmentioning

confidence: 99%

Synergistic antitumor efficacy of rMV-Hu191 and Olaparib in pancreatic cancer by generating oxidative DNA damage and ROS-dependent apoptosis

Zhang,

Jiang,

Zhou

et al. 2024

Translational Oncology

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Nrf2 affects hydroquinone-induces cell cycle arrest through the p16/pRb signaling pathway and antioxidant enzymes

Chen

Zhai

Gao

et al. 2023

Ecotoxicology and Environmental Safety

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Poly(ADP-ribose)polymerase-1 affects hydroquinone-induced aberrant cell cycle and apoptosis through activation of p16/pRb signaling pathway in TK6 cells

Cited by 6 publications

References 26 publications

JNK1 activated pRb/E2F1 and inhibited p53/p21 signaling pathway is involved in hydroquinone‐induced pathway malignant transformation of TK6 cells by accelerating the cell cycle progression

JNK1 activated pRb/E2F1 and inhibited p53/p21 signaling pathway is involved in hydroquinone‐induced pathway malignant transformation of TK6 cells by accelerating the cell cycle progression

Synergistic antitumor efficacy of rMV-Hu191 and Olaparib in pancreatic cancer by generating oxidative DNA damage and ROS-dependent apoptosis

Nrf2 affects hydroquinone-induces cell cycle arrest through the p16/pRb signaling pathway and antioxidant enzymes

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