(Poly)acrylonitrile-based hydrogel as a therapeutic bulking agent in urology

Ramseyer, Pascal; Meagher‐Villemure, Kathleen; Bürki, Marco; Frey, Peter

doi:10.1016/j.biomaterials.2006.09.019

Cited by 13 publications

(9 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With such a design based on a chemical-physical double-network, many formulations are conceivable. It is obvious that the covalently cross-linked network can be either of the many known polymer hydrogels. − By contrast, the choice of the physical network is relatively limited because not only should it be self-healable, but also, for the shape memory effect, it can be formed or enhanced at a later stage with the hydrogel under deformation or strain. The physical hydrogel of PVA, which is biocompatible and has good mechanical properties, , is an excellent candidate to be combined with other chemically cross-linked polymer hydrogels.…”

Section: Resultsmentioning

confidence: 99%

Poly(vinyl alcohol)–Poly(ethylene glycol) Double-Network Hydrogel: A General Approach to Shape Memory and Self-Healing Functionalities

et al. 2015

View full text Add to dashboard Cite

A double-network polymer hydrogel composed of chemically cross-linked poly(ethylene glycol) (PEG) and physically cross-linked poly(vinyl alcohol) (PVA) was prepared. When the hydrogel (70 wt % of water) is subjected to freezing/thawing treatment under strain, the enhanced physical network as a result of crystallization of PVA chains can stabilize the hydrogel deformation after removal of the external force at room temperature. Subsequent disruption of the physical network of PVA by heating allows for the recovery of the initial shape of the hydrogel. Moreover, the double-network hydrogel exhibits self-healing capability stemming from the physical network of PVA by virtue of the extensive interchain hydrogen bonding between the hydroxyl side groups. This study thus demonstrates a general approach to imparting both the shape memory and self-healing properties to chemically cross-linked hydrogels that otherwise do not have such functionalities. Moreover, by making use of the fixed hydrogel elongation, the effect of anisotropy arising from chain orientation on the self-healing was also observed.

show abstract

Section: Resultsmentioning

confidence: 99%

Poly(vinyl alcohol)–Poly(ethylene glycol) Double-Network Hydrogel: A General Approach to Shape Memory and Self-Healing Functionalities

et al. 2015

View full text Add to dashboard Cite

show abstract

“…21 Although the hydrophilicity of PAN was improved by hydrolysis, the mechanical performance was seriously affected due to the damage of CN-CN dipole interactions, and moreover, the hydrolyzed PAN is not parent PAN in the strict sense. 22 Qiu and Park reported on superporous PAN IPN hydrogels composed of N,N 0 -methylenebisacrylamide crosslinked poly-(acrylamide-co-3-sulfopropyl acrylate potassium salt) [poly(AMco-SPAK)] and PAN networks. Notwithstanding that over tens of swelling ratio and increased mechanical strength are achieved for IPN gels, the maximum tensile and compressive stresses of these gels were only 11 KPa and 175 KPa, respectively, much lower than those of high strength hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Construction of an ultrahigh strength hydrogel with excellent fatigue resistance based on strong dipole–dipole interaction

et al. 2011

View full text Add to dashboard Cite

A high strength hydrogel was fabricated by one-step copolymerization of dipole-dipole interactioncontaining monomer, acrylonitrile, super-hydrophilic comonomer, 2-methacryloyloxyethyl phosphorylcholine and crosslinker, polyethylene glycol diacrylate (M n ¼ 575, PEGDA575). This dipole-dipole reinforced (DDR) hydrogel demonstrated intriguing combinations of properties such as withstanding several MPa tensile stress, tens of MPa compressive strength, excellent fatigue resistance and no yielding during tensile tests. The equilibrium water content and transparency of DDR hydrogels could be tuned by varying monomer concentration and monomer ratio. The gels exhibited low cytotoxicity and antifouling characteristic. Biodegradable high strength hydrogel could also be constructed by merely replacing PEGDA575 with bioreducible crosslinker. The method reported here offers a general strategy to design biocompatible high-strength hydrogels for tissue engineering scaffolds by copolymerizing monomer containing dipole-dipole pairing with other hydrophilic monomer.

show abstract

“…Unfortunately, stationary charges on the fiber go away slowly. On the other hand, PAN fiber is always a good candidate for biomaterials, for example, as artificial muscles, because of its excellent biocompatibility [20,21]. This is greatly significant since many activities in people's body are connected with bioelectricity, such as nerve regeneration and cell growth.…”

Section: Introductionmentioning

confidence: 99%

Conductive polymers/polyacrylonitrile composite fibers: Fabrication and properties

Xia

2009

Polymer Composites

View full text Add to dashboard Cite

Polypyrrole/polyacrylonitrile, polyaniline/polyacrylonitrile, and poly(3,4-ethylenedioxythiophene)/polyacrylonitrile composite fibres were fabricated successfully by in situ polymerization. The morphologic observations confirmed the uniformly-covered polyacrylonitrile fiber surface by conductive conjugated polymers. These composite fibers exhibited conductivity in the range of 1.4 3 10 22 to 5.2 3 10 21 S cm 21 . Improved thermal stability of the composite fibers was observed from thermogravimetric analysis results. Structural analysis indicated that the interactions of both hydrogen-bonding and the electrostatic attraction existed between polyacrylonitrile chains and conjugated polymers. These novel composite fibers still possessed original fibrillar morphology and strength properties and showed a good stability to atmosphere and washing. POLYM. COMPOS.,

show abstract

(Poly)acrylonitrile-based hydrogel as a therapeutic bulking agent in urology

Cited by 13 publications

References 9 publications

Poly(vinyl alcohol)–Poly(ethylene glycol) Double-Network Hydrogel: A General Approach to Shape Memory and Self-Healing Functionalities

Poly(vinyl alcohol)–Poly(ethylene glycol) Double-Network Hydrogel: A General Approach to Shape Memory and Self-Healing Functionalities

Construction of an ultrahigh strength hydrogel with excellent fatigue resistance based on strong dipole–dipole interaction

Conductive polymers/polyacrylonitrile composite fibers: Fabrication and properties

Contact Info

Product

Resources

About