Poly(acrylic acid)‐<i>graft</i>‐poly(ethylene glycol) preparation and adsorption on polyelectrolyte multilayers (PEMs) for custom‐made antiadhesive surfaces

Schmolke, Hannah; Hartwig, Sven; Klages, Claus‐Peter

doi:10.1002/pssa.201100002

Cited by 7 publications

(3 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high surface of metal within the tubular reactor might have a role since poly(acrylic acid) had been shown to adsorb onto metal and metal oxide surfaces . In addition, it had been demonstrated that the adsorption density was increased with higher molar mass .…”

Section: Resultsmentioning

confidence: 99%

Modular, Flexible, and Continuous Plant for Radical Polymerization in Aqueous Solution

Kohlmann

Chevrel

Hoppe

et al. 2016

Macro Reaction Engineering

View full text Add to dashboard Cite

The European project F 3 Factory aims at designing small to medium scale plants consisting of standardized container assemblies for delocalized production of various chemicals. Within the framework of the F 3 Factory project, the design of a modular, multiproduct, and continuous plant for manufacturing water-soluble polymers is addressed. Free radical polymerization in aqueous solution is examined through two industrial cases: polymerization of acrylic acid (AA) in the presence of chain transfer agent (CTA) and copolymerization of AA with one comonomer. A methodology for performing the transition from batch recipes to continuous operations is proposed. Offl ine and inline monitoring of monomer consumption is achieved using Raman spectroscopy combined with chemometrics. A modular pilot plant meeting the requirements of F 3 Factory project is designed and demonstrated at INVITE (Bayer, Leverkusen). The two polymerization processes are successively operated in the same pilot plant separated by an intermediate extensive washing. For each process, several polymer grades are produced by modifi cation of reaction conditions (inlet fl ow of CTA or reactor temperature). Transition dynamics are characterized using inline monitoring. The fl exibility of the modular plant is demonstrated.

show abstract

Section: Resultsmentioning

confidence: 99%

Modular, Flexible, and Continuous Plant for Radical Polymerization in Aqueous Solution

Kohlmann

Chevrel

Hoppe

et al. 2016

Macro Reaction Engineering

View full text Add to dashboard Cite

show abstract

“…The grafting of PCL and PAA may be a means to couple the mechanical property of PCL and the hydrogel property of PAA. The grafting of PAA to polymers, such as poly(vinyl alcohol) (PVA) [ 28 ], poly(lactic acid) (PLA) [ 29 ], and poly(ethylene glycol) (PEG) [ 30 ] is a feasible method for modifying polymers. Guo et al [ 31 ] synthesized core/shell-PS/PAA particles through photopolymerization and proposed a method for fabricating a PAA grafting polymer by using photoinitiators.…”

Section: Introductionmentioning

confidence: 99%

Microstructure and Biological Properties of Electrospun In Situ Polymerization of Polycaprolactone-Graft-Polyacrylic Acid Nanofibers and Its Composite Nanofiber Dressings

Huang

Lai

et al. 2021

Polymers

View full text Add to dashboard Cite

In this study, polycaprolactone (PCL)- and poly(acrylic acid) (PAA)-based electrospun nanofibers were prepared for the carriers of antimicrobials and designed composite nanofiber mats for chronic wound care. The PCL- and PAA-based electrospun nanofibers were prepared through in situ polymerization starting from PCL and acrylic acid (AA). Different amounts of AA were introduced to improve the hydrophilicity of the PCL electrospun nanofibers. A compatibilizer and a photoinitiator were then added to the electrospinning solution to form a grafted structure composed of PCL and PAA (PCL-g-PAA). The grafted PAA was mainly located on the surface of a PCL nanofiber. The optimization of the composition of PCL, AA, compatibilizer, and photoinitiator was studied, and the PCL-g-PAA electrospun nanofibers were characterized through scanning electron microscopy and 1H-NMR spectroscopy. Results showed that the addition of AA to PCL improved the hydrophilicity of the electrospun PCL nanofibers, and a PCL/AA ratio of 80/20 presented the best composition and had smooth nanofiber morphology. Moreover, poly[2 -(tert-butylaminoethyl) methacrylate]-grafted graphene oxide nanosheets (GO-g-PTA) functioned as an antimicrobial agent and was used as filler for PCL-g-PAA nanofibers in the preparation of composite nanofiber mats, which exerted synergistic effects promoted by the antibacterial properties of GO-g-PTA and the hydrophilicity of PCL-g-PAA electrospun nanofibers. Thus, the composite nanofiber mats had antibacterial properties and absorbed body fluids in the wound healing process, thereby promoting cell proliferation. The biodegradation of the PCL-g-PAA electrospun nanofibers also demonstrated an encouraging result of three-fold weight reduction compared to the neat PCL nanofiber. Our findings may serve as guidelines for the fabrication of electrospun nanofiber composites that can be used mats for chronic wound care.

show abstract

“…The PEG monodispersity also influences on antifouling propertiers [19]. A useful method to immobilize PEG chains on the charged surface is to use pegylated polyelectrolytes, such as poly (l-lysine) (PLL), poly (l-glutamic acid) (PGA), or poly (acrylic acid) (PAA) [20][21][22][23][24]. Such polyelectrolytes with grafted PEG chains are deposited by electrostatic interactions between the charged backbone and the oppositely charged surface [25].…”

Section: Introductionmentioning

confidence: 99%

Control of Specific/Nonspecific Protein Adsorption: Functionalization of Polyelectrolyte Multilayer Films as a Potential Coating for Biosensors

et al. 2021

View full text Add to dashboard Cite

Control of nonspecific/specific protein adsorption is the main goal in the design of novel biomaterials, implants, drug delivery systems, and sensors. The specific functionalization of biomaterials can be achieved by proper surface modification. One of the important strategies is covering the materials with functional coatings. Therefore, our work aimed to functionalize multilayer coating to control nonspecific/specific protein adsorption. The polyelectrolyte coating was formed using a layer-by-layer technique (LbL) with biocompatible polyelectrolytes poly-L-lysine hydrobromide (PLL) and poly-L-glutamic acid (PGA). Nonspecific protein adsorption was minimized/eliminated by pegylation of multilayer films, which was achieved by adsorption of pegylated polycations (PLL-g-PEG). The influence of poly (ethylene glycol) chain length on eliminating nonspecific protein adsorption was confirmed. Moreover, to achieve specific protein adsorption, the multilayer film was also functionalized by immobilization of antibodies via a streptavidin bridge. The functional coatings were tested, and the adsorption of the following proteins confirmed the ability to control nonspecific/specific adsorption: human serum albumin (HSA), fibrinogen (FIB), fetal bovine serum (FBS), carcinoembryonic antigen human (CEA) monitored by quartz crystal microbalance with dissipation (QCM-D). AFM imaging of unmodified and modified multilayer surfaces was also performed. Functional multilayer films are believed to have the potential as a novel platform for biotechnological applications, such as biosensors and nanocarriers for drug delivery systems.

show abstract

Poly(acrylic acid)‐graft‐poly(ethylene glycol) preparation and adsorption on polyelectrolyte multilayers (PEMs) for custom‐made antiadhesive surfaces

Cited by 7 publications

References 51 publications

Modular, Flexible, and Continuous Plant for Radical Polymerization in Aqueous Solution

Modular, Flexible, and Continuous Plant for Radical Polymerization in Aqueous Solution

Microstructure and Biological Properties of Electrospun In Situ Polymerization of Polycaprolactone-Graft-Polyacrylic Acid Nanofibers and Its Composite Nanofiber Dressings

Control of Specific/Nonspecific Protein Adsorption: Functionalization of Polyelectrolyte Multilayer Films as a Potential Coating for Biosensors

Contact Info

Product

Resources

About