Poly(acrylic acid)-directed synthesis of colloidally stable single domain magnetite nanoparticles via partial oxidation

Altan, Cem L.; Gurten, Berna; Sadza, Roel; Yenigül, Elçin; Sommerdijk, Nico A. J. M.; Bucak, Şeyda

doi:10.1016/j.jmmm.2016.05.009

Cited by 18 publications

(16 citation statements)

References 54 publications

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“…Also, these gaps between the subunits were not uniformly distributed in the structure but with subunits that appear to have partially coalesced. Because the carboxylic acid groups of pAA are known to strongly interact with the Fe ions on the surface of Fe 3 O 4 , these gaps contain most probably the polymer that was adsorbed on subunits during the formation process, in agreement with what was previously observed by elemental analysis of magnetite mesocrystals formed in the presence of polyarginine …”

Section: Results and Discussionsupporting

confidence: 87%

“…Magnetite nanoclusters can be synthesized at high temperatures (>90 °C) by polyol methods. ,− Depending on the specific polymer that is used during synthesis, the crystal size can vary over a wide range (35–200 nm). The resulting magnetite crystals consist of smaller subdomains arranged into a flower-like morphology that are often crystallographically aligned.…”

Section: Introductionmentioning

confidence: 99%

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Understanding the Formation Mechanism of Magnetic Mesocrystals with (Cryo-)Electron Microscopy

et al. 2019

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Magnetite (Fe3O4) nanoaggregates with a flower-like morphology are considered promising materials in the field of magnetically induced hyperthermia in cancer therapy due to their good heating efficiency at low applied alternating magnetic fields. Although the structure and the magnetic state of such flower-like aggregates have been investigated previously, the mechanism that leads to the hierarchical morphology is still poorly understood. Here, we study the formation mechanism of Fe3O4 aggregates synthesized through the partial oxidation of ferrous hydroxide in the presence of poly(acrylic acid) by using cryogenic electron microscopy. The aggregates are formed through a multistep process involving first the conversion of ferrous hydroxide precursors in ∼5 nm primary particles that aggregate into ∼10 nm primary Fe3O4 crystals that finally arrange into the secondary mesocrystal structure. High-resolution electron tomography is used to show that the Fe3O4 mesocrystals are composed of ∼10 nm subunits, often showing a uniform crystallographic orientation resulting in single-crystal-like diffraction patterns. Furthermore, electron holography reveals that mesocrystals have a single magnetic domain despite polymeric interfaces between subunits being present throughout the mesocrystal. Our findings could be used to design materials with specific properties by modulating the morphology and/or magnetic state that is suitable for biomedical application.

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Section: Results and Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Understanding the Formation Mechanism of Magnetic Mesocrystals with (Cryo-)Electron Microscopy

et al. 2019

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“…There are several established SPIONs synthesis methods, including co-precipitation, microemulsion, sol-gel, hydrothermal and thermal decomposition [2,[7][8][9][12][13][14][15][16]18,20,22,24,25,[28][29][30], each of those displaying advantages as well as drawbacks.…”

Section: Introductionmentioning

confidence: 99%

One-Step Soft Chemical Synthesis of Magnetite Nanoparticles under Inert Gas Atmosphere. Magnetic Properties and In Vitro Study

et al. 2020

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Iron oxide nanoparticles have received remarkable attention in different applications. For biomedical applications, they need to possess suitable core size, acceptable hydrodynamic diameter, high saturation magnetization, and reduced toxicity. Our aim is to control the synthesis parameters of nanostructured iron oxides in order to obtain magnetite nanoparticles in a single step, in environmentally friendly conditions, under inert gas atmosphere. The physical–chemical, structural, magnetic, and biocompatible properties of magnetite prepared by hydrothermal method in different temperature and pressure conditions have been explored. Magnetite formation has been proved by Fourier-transform infrared spectroscopy and X-ray diffraction characterization. It has been found that crystallite size increases with pressure and temperature increase, while hydrodynamic diameter is influenced by temperature. Magnetic measurements indicated that the magnetic core of particles synthesized at high temperature is larger, in accordance with the crystallite size analysis. Particles synthesized at 100 °C have nearly identical magnetic moments, at 20 × 103 μB, corresponding to magnetic cores of 10–11 nm, while the particles synthesized at 200 °C show slightly higher magnetic moments (25 × 103 μB) and larger magnetic cores (13 nm). Viability test results revealed that the particles show only minor intrinsic toxicity, meaning that these particles could be suited for biomedical applications.

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“…In conclusion, we show that SP as well as SSD magnetite nanoparticles can be selectively grown in the presence of polyR simply by changing the pH of the precipitation solution. Even though the effect of pH, , and of biological , and synthetic additives on the precipitation of magnetite has been extensively studied within recent years, we believe that the presented control over size and size distribution of the nanoparticles is exceptional. We thus combine many of the previously reported advantages in one system.…”

mentioning

confidence: 99%

Shaping Magnetite with Poly-l-arginine and pH: From Small Single Crystals to Large Mesocrystals

Kuhrts

Macías‐Sánchez

Tarakina

et al. 2019

J. Phys. Chem. Lett.

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Control over particle size, size distribution, and colloidal stability are central aims in producing functional nanomaterials. Recently, biomimetic approaches have been successfully used to enhance control over properties in the synthesis of those materials. Magnetotactic bacteria produce protein-stabilized magnetite away from its thermodynamic equilibrium structure. Mimicking the bacteria’s proteins using poly-l-arginine we show that by simply increasing the pH, the dimensions of magnetite increase and a single- to mesocrystal transformation is induced. Using synchrotron X-ray diffraction and transmission electron microscopy, we show that magnetite nanoparticles with narrow size distributions and average diameters of 10 ± 2 nm for pH 9, 20 ± 2 nm for pH 10, and up to 40 ± 4 nm for pH 11 can be synthesized. We thus selectively produce superparamagnetic and stable single-domain particles merely by controlling the pH. Remarkably, while an increase in pH brings about a thermodynamically driven decrease in size for magnetite without additives, this dependency on pH is inverted when poly-l-arginine is present.

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Poly(acrylic acid)-directed synthesis of colloidally stable single domain magnetite nanoparticles via partial oxidation

Cited by 18 publications

References 54 publications

Understanding the Formation Mechanism of Magnetic Mesocrystals with (Cryo-)Electron Microscopy

Understanding the Formation Mechanism of Magnetic Mesocrystals with (Cryo-)Electron Microscopy

One-Step Soft Chemical Synthesis of Magnetite Nanoparticles under Inert Gas Atmosphere. Magnetic Properties and In Vitro Study

Shaping Magnetite with Poly-l-arginine and pH: From Small Single Crystals to Large Mesocrystals

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