Poly(A)-Attached RNA as Activator in Embryonic Differentiation

Cardiac-Like Action Potentials Recorded from Spontaneously-Contracting Structures Induced in Post-Nodal Pieces of Chick Blastoderm Exposed to an RNA-Enriched Fraction from Adult Heart

“…These channels are insensitive to tetrodotoxin (TTX), a blocker of fast Na+ channels. Fast Na+ channels appear suddenly on about day 5 , and increase in numbers thereafter causing the rate of rise to increase to about 150 V/s by day 16. The resting potential also increases during development, due to an increase in Kf permeability, and attains the adult level of about -80mV by day 12 [2, 31. Adult-like appearance of the myofibrils and general ultrastructure is attained by day 18.…”