Poly(3-hydroxybutyrate)/ZnO Bionanocomposites with Improved Mechanical, Barrier and Antibacterial Properties

Díez‐Pascual, Ana M.; Díez-Vicente, Angel L.

doi:10.3390/ijms150610950

Cited by 222 publications

(137 citation statements)

References 49 publications

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“…The morphologic change of inorganic materials from a rough to a smooth surface is often observed when inorganic materials are covered with organic moieties. [36][37][38] Thus, the smooth surfaces of B-Cal and N-Cal in physiological fluids observed in the present study could have been due to corona formation.…”

Section: Discussionmentioning

confidence: 79%

The fate of calcium carbonate nanoparticles administered by oral route: absorption and their interaction with biological matrices

Lee

Kim

et al. 2015

IJN

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Background Orally administered particles rapidly interact with biological fluids containing proteins, enzymes, electrolytes, and other biomolecules to eventually form particles covered by a corona, and this corona potentially affects particle uptake, fate, absorption, distribution, and elimination in vivo. This study explored relationships between the biological interactions of calcium carbonate particles and their biokinetics. Methods We examined the effects of food grade calcium carbonates of different particle size (nano [N-Cal] and bulk [B-Cal]: specific surface areas of 15.8 and 0.83 m 2 /g, respectively) on biological interactions in in vitro simulated physiological fluids, ex vivo biofluids, and in vivo in gastrointestinal fluid. Moreover, absorption and tissue distribution of calcium carbonates were evaluated following a single dose oral administration to rats. Results N-Cal interacted more with biomatrices than bulk materials in vitro and ex vivo, as evidenced by high fluorescence quenching ratios, but it did not interact more actively with biomatrices in vivo. Analysis of coronas revealed that immunoglobulin, apolipoprotein, thrombin, and fibrinogen, were the major corona proteins, regardless of particle size. A biokinetic study revealed that orally delivered N-Cal was more rapidly absorbed into the blood stream than B-Cal, but no significant differences were observed between the two in terms of absorption efficiencies or tissue distributions. Both calcium carbonates were primarily present as particulate forms in gastrointestinal fluids but enter the circulatory system in dissolved Ca 2+ , although both types showed partial phase transformation to dicalcium phosphate dihydrate. Relatively low dissolution (about 4%), no remarkable protein–particle interaction, and the major particulate fate of calcium carbonate in vivo gastrointestinal fluids can explain its low oral absorption (about 4%) regardless of particle size. Conclusion We conclude that calcium carbonate nanoparticles can act more actively with biological matrices in vitro and ex vivo, but that in vivo, their biological interactions and biokinetics are not affected by particle size.

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Section: Discussionmentioning

confidence: 79%

The fate of calcium carbonate nanoparticles administered by oral route: absorption and their interaction with biological matrices

Lee

Kim

et al. 2015

IJN

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“…P(R)-HB [93][94][95][96][97], and bacterial copolymers such as P(3HB-co-4HB) [98][99][100], PHBV [101][102][103] or PHBH and derivatives [104][105][106], have been used for the elaboration of self-assembled systems such as DDSs, tissue engineering scaffolds and implants [107][108][109][110]. Those polymers have been chosen for their biodegradability and biocompatibility.…”

Section: Chemically Modified Bacterial Phb-based (Co)polymersmentioning

confidence: 99%

Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers

Barouti

Jaffredo

Guillaume

2017

Progress in Polymer Science

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International audienceWithin the general context of nanomedicine, drug delivery systems based on polymers have sparkeda rapidly growing interest and raised many efforts to tackle various diseases, among which cancer.Polyester-based nanoparticulate drug delivery systems, including polymer-drug conjugates andamphiphilic block copolymers, represent a major class with promising outcomes, especially for thosederived from poly(3-hydroxybutyrate) (PHB). This review describes recent advances in drug delivery systemsdesigned from the self-assembly of synthetic (co)polymers derived from PHB. The various strategiesfor the synthesis of PHB-conjugates, PHB/poly(ethylene glycol) (PEG) and other PHB-based copolymersare first summarized. Nanoparticles, micelles, microparticles, and hydrogels elaborated from these(co)polymers following various preparation methods, along with their exploitation in the encapsulationand release of various therapeutic agents, are next detailed. Finally, we discuss the synthetic challenges,drug delivery outlooks, and perspectives of PHB-based drug delivery systems. Engineered nano-scaledmaterials based on PHB self-assembled systems are thus anticipated to emerge as a valuable platformfor original drug delivery systems

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“…The films of PLA and PLA/5% ZnO were then applied on the ham and the samples were stored at 4 °C for 5 days. Irradiation treatments were done at the Canadian Irradiation Center, using a UC-15 A (SS canister) underwater calibrator (Nordion Inc., Kanata, ON, Canada) equipped with a 60 Co source. A γ-radiation dose of 0.3 kGy was delivered at a dose rate of 13.5 kGy/h.…”

Section: Inoculation and Treatment Of Hammentioning

confidence: 99%

Effect of PLA/ZnO Packaging and Gamma Radiation on the Content of Listeria innocua, Escherichia coli and Salmonella enterica on Ham during Storage at 4 °C

Marra¹,

Boumail²,

Cimmino³

et al. 2016

JFSE

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Abstract:The effect of ZnO and low γ-radiation on PLA based-films was investigated to be used for food packaging application. Ham slices were inoculated with E. coli, L. innocua and S. enterica and then covered with PLA and PLA/5% ZnO films. The samples were irradiated with a γ-radiation dose of 0.3 kGy at dose rate of 13.5 kGy/h. Microbiological analysis was performed at 0, 1 and 5 days on samples stored at 4 °C. Results showed that no consistent reduction of bacteria was obtained, even at the fifth day of storage, when the ham was covered with PLA/5% ZnO film and no γ-radiation was performed. The use of γ-radiation results necessary to reduce the bacteria growth. In fact E. coli and S. enterica were not detected after 5 days of storage; whereas in the case of test with L. innocua a reduction of 1.3 log CFU/g was observed after 5 days of storage. The antibacterial results indicate that the presence of ZnO in PLA film is effective only for E. coli. The differences of the results obtained here with those reported in literature (where ZnO particles are reported to be very effective as antimicrobial material) are accounted for the different methodologies used. In conclusion considering the positive results, even if small, obtained here at least only for the E. Coli and considering that PLA/5% ZnO film shows, compared to plain PLA film, good tensile properties (especially Young's modulus and stress at yielding) and good permeability (to O 2 and CO 2 ) induce to consider the PLA/5% ZnO composite film usable for food packaging when long shelf life and food safety are required, considering also that it is biodegradable and compostable.

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Poly(3-hydroxybutyrate)/ZnO Bionanocomposites with Improved Mechanical, Barrier and Antibacterial Properties

Cited by 222 publications

References 49 publications

The fate of calcium carbonate nanoparticles administered by oral route: absorption and their interaction with biological matrices

The fate of calcium carbonate nanoparticles administered by oral route: absorption and their interaction with biological matrices

Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers

Effect of PLA/ZnO Packaging and Gamma Radiation on the Content of Listeria innocua, Escherichia coli and Salmonella enterica on Ham during Storage at 4 °C

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