Poly(3-hydroxybutyrate)/poly(amine)-coated nickel oxide nanoparticles for norfloxacin delivery: antibacterial and cytotoxicity efficiency

Salahuddin, Nehal; Gaber, Mohamed; Mousa, Maie; Abdelwahab, Mohamed A.

doi:10.1039/d0ra04784h

Cited by 13 publications

(5 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…33 PHB showed characteristic peaks at 2974 and 2931 cm À1 (C H stretching), 1720 cm À1 (ester carbonyl group C=O), 1454 cm À1 (C H asymmetric deformation), 1379 cm À1 (H C O in plan bending), 1275 cm À1 (C O C backbone asymmetric stretching vibration), 1227 cm À1 (C C O asymmetric stretching), 1180 cm À1 (C C O backbone methylene wagging), and 1130 and 1100 cm À1 (C O C stretching vibration). [34][35][36][37][38] The PHB composites containing ZnO particles presented a similar spectrum to pristine PHB, as observed in Figure 3(B), associated with its major chemical composition, i.e., polymeric matrix. As highlighted in Figure 3(C) and (D), few spectral changes are related to ZnO presence and interaction with the polymeric structure.…”

Section: Fourier-transform Infrared Spectroscopysupporting

confidence: 56%

A promising sustainable PHB‐ZnO composite for development of biodegradable filaments

et al. 2021

View full text Add to dashboard Cite

The development of new biodegradable composites with superior properties is an attractive approach to develop environmentally friendly materials with new potential applications. In this work, we prepared and characterized PHB filaments with different concentrations of ZnO particles (from 0.5 up to 16 wt%) to evaluate this mixture's effect on the physico-chemical, thermal properties, and morphological biofilament characteristics. The FTIR and Raman results indicated a possible chemical interaction between the ZnO and PHB, altering the helical polymeric and crystalline structure. The ZnO particles increased the composites' thermal stability, mainly at higher filler contents, confirmed

show abstract

Section: Fourier-transform Infrared Spectroscopysupporting

confidence: 56%

A promising sustainable PHB‐ZnO composite for development of biodegradable filaments

et al. 2021

View full text Add to dashboard Cite

show abstract

“…This was also confirmed by the disappearance of the C=O stretching vibration at 1734.5 (Supporting Informa- tion File 1, Figure S1). Such peak shifts are also observed when NOR interacts with metal ions like NiO [41]. The zeta potential of these particles was found to be +29 mV, validating the loading of drug and indicating nanoparticle stability at neutral pH.…”

Section: Characterization Of Uncoated Iron Oxide Nanoparticles and Normentioning

confidence: 59%

“…These nanoparticles were stable in aqueous dispersion, due to electrostatic repulsion from the existing charge on their surfaces. We find that, compared to pH 10, an acidic pH of 5 enhances the drug coating on IONPs, in the range of 4.7 to 5.7 times, achieving a NOR loading efficiency almost equivalent to polymeric nanoparticles composed of poly (3-hydroxybutyrate) [41]. This high drug loading was also reflected by the presence of prominent NOR peaks in the FTIR spectrum of NOR@IONP pH5 , compared to that in NOR@IONP pH10 .…”

Section: Discussionmentioning

confidence: 75%

“…The drug release profile from NOR@IONP pH10 resembled that of free NOR where the release was rapid over the first 4-6 h and saturated out there after (Figure 5b, inset). The release of NOR from metal oxides, NiO, is found to follow first order rate kinetics thus we too fitted out drug release plots to a first order model [41].…”

Section: Drug Release and Coating Estimationmentioning

confidence: 99%

See 1 more Smart Citation

pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages

Cotta¹,

Mehra²,

Bandyopadhyaya³

2021

Beilstein J. Nanotechnol.

View full text Add to dashboard Cite

Nanoparticle deployment in drug delivery is contingent upon controlled drug loading and a desired release profile, with simultaneous biocompatibility and cellular targeting. Iron oxide nanoparticles (IONPs), being biocompatible, are used as drug carriers. However, to prevent aggregation of bare IONPs, they are coated with stabilizing agents. We hypothesize that, zwitterionic drugs like norfloxacin (NOR, a fluoroquinolone) can manifest dual functionality – nanoparticle stabilization and antibiotic activity, eliminating the need of a separate stabilizing agent. Since these drugs have different charges, depending on the surrounding pH, drug loading enhancement could be pH dependent. Hence, upon synthesizing IONPs, they were coated with NOR, either at pH 5 (predominantly as cationic, NOR+) or at pH 10 (predominantly as anionic, NOR−). We observed that, drug loading at pH 5 exceeded that at pH 10 by 4.7–5.7 times. Furthermore, only the former (pH 5 system) exhibited a desirable slower drug release profile, compared to the free drug. NOR-coated IONPs also enable a 22 times higher drug accumulation in macrophages, compared to identical extracellular concentrations of the free drug. Thus, lowering the drug coating pH to 5 imparts multiple benefits – improved IONP stability, enhanced drug coating, higher drug uptake in macrophages at reduced toxicity and slower drug release.

show abstract

“…When Energy Dispersive X-ray Spectrometer (EDS/EDX) is associated with scanning electron microscope, qualitative and quantitative chemical analysis information of the sample can be obtained [ 223 , 224 ]. The EDX analysis of PHB/polyamine–NiO nanocomposites indicated the presence of Nikel, Carbon, and Oxygen where the ratio of Nickel: Oxygen was 7.33:31.08 [ 225 ].…”

Section: Characterization Of Nanoparticlesmentioning

confidence: 99%

The Synthesis, Characterization and Applications of Polyhydroxyalkanoates (PHAs) and PHA-Based Nanoparticles

et al. 2021

View full text Add to dashboard Cite

Polyhydroxyalkanoates (PHAs) are storage granules found in bacteria that are essentially hydroxy fatty acid polyesters. PHA molecules appear in variety of structures, and amongst all types of PHAs, polyhydroxybutyrate (PHB) is used in versatile fields as it is a biodegradable, biocompatible, and ecologically safe thermoplastic. The unique physicochemical characteristics of these PHAs have made them applicable in nanotechnology, tissue engineering, and other biomedical applications. In this review, the optimization, extraction, and characterization of PHAs are described. Their production and application in nanotechnology are also portrayed in this review, and the precise and various production methods of PHA-based nanoparticles, such as emulsion solvent diffusion, nanoprecipitation, and dialysis are discussed. The characterization techniques such as UV-Vis, FTIR, SEM, Zeta Potential, and XRD are also elaborated.

show abstract

Poly(3-hydroxybutyrate)/poly(amine)-coated nickel oxide nanoparticles for norfloxacin delivery: antibacterial and cytotoxicity efficiency

Abstract: PHB/poly(amine)-coated NiO nanoparticles for NOR delivery: antibacterial and cytotoxicity efficiency.

Cited by 13 publications

References 66 publications

A promising sustainable PHB‐ZnO composite for development of biodegradable filaments

A promising sustainable PHB‐ZnO composite for development of biodegradable filaments

pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages

The Synthesis, Characterization and Applications of Polyhydroxyalkanoates (PHAs) and PHA-Based Nanoparticles

Contact Info

Product

Resources

About