Poly(3-hydroxybutyrate)-P(3HB): Review of Production Process Technology

AlvesMariane, I; MacagnanKarine, L; RodriguesAmanda, A; Assis, Dener Acosta de; TorresMatheus, M; OliveiraPatrícia, D de; FurlanLígia,; VendruscoloClaire, T; Moreira, Angelita da Silveira

doi:10.1089/ind.2017.0013

Cited by 32 publications

(7 citation statements)

References 68 publications

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“…Bio-based can usually be obtained from agricultural waste using microorganisms. Maraveas concluded that environmentally friendly or biodegradable plastics derived from renewable carbon provides benefit as they allow sustainable use of agricultural waste, improve soil fertility at a good rate of biodegradability, and reduces environmental burden imposed on consumers [ 25 ].…”

Section: Current Situation Of Global Plasticmentioning

confidence: 99%

Recent Advances in the Biosynthesis of Polyhydroxyalkanoates from Lignocellulosic Feedstocks

Vigneswari

Noor

Amelia

et al. 2021

Life

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Polyhydroxyalkanoates (PHA) are biodegradable polymers that are considered able to replace synthetic plastic because their biochemical characteristics are in some cases the same as other biodegradable polymers. However, due to the disadvantages of costly and non-renewable carbon sources, the production of PHA has been lower in the industrial sector against conventional plastics. At the same time, first-generation sugar-based cultivated feedstocks as substrates for PHA production threatens food security and considerably require other resources such as land and energy. Therefore, attempts have been made in pursuit of suitable sustainable and affordable sources of carbon to reduce production costs. Thus, in this review, we highlight utilising waste lignocellulosic feedstocks (LF) as a renewable and inexpensive carbon source to produce PHA. These waste feedstocks, second-generation plant lignocellulosic biomass, such as maize stoves, dedicated energy crops, rice straws, wood chips, are commonly available renewable biomass sources with a steady supply of about 150 billion tonnes per year of global yield. The generation of PHA from lignocellulose is still in its infancy, hence more screening of lignocellulosic materials and improvements in downstream processing and substrate pre-treatment are needed in the future to further advance the biopolymer sector.

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Section: Current Situation Of Global Plasticmentioning

confidence: 99%

Recent Advances in the Biosynthesis of Polyhydroxyalkanoates from Lignocellulosic Feedstocks

Vigneswari

Noor

Amelia

et al. 2021

Life

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“…An increase in DCW with the decrease in P(3HB) is indicative of high cell multiplication and polymer degradation to supply energy and carbon, as the metabolism of the microorganisms is governed by the growth medium. With a balanced growth, the microorganism uses the substrate as an energy source and/or for the maintenance/formation of cellular material [32, 33].…”

Section: Resultsmentioning

confidence: 99%

Optimization of Ralstonia solanacearum cell growth using a central composite rotational design for the P(3HB) production: Effect of agitation and aeration

et al. 2019

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The intracellular accumulation of polyhydroxyalkanoates (PHAs) normally occurs after cell growth, during the second fermentation stage and under nutrient-limited conditions in the presence of a carbon excess. However, some microorganisms are able to accumulate PHAs as poly(3-hydroxybutyrate) [P(3HB)] during the first fermentation stage, the cell growth phase, without nutrient limitation, once they have been reported to utilize type II metabolism during the polymer accumulation phase. This study evaluated the effect of aeration and agitation on cell growth and P(3HB) accumulation in Ralstonia solanacearum RS, performed in a bioreactor for 24h at 32°C. A 22 central composite rotational design (CCRD) was used, with agitation (150 to 250 rpm) and aeration (0.3 to 1 vvm) as independent variables and optical density (OD600nm), dry cell weight (DCW), and P(3HB) yield as dependent variables. A significant polymer accumulation, until 70% of P(3HB), was observed, proving that R. solanacearum RS exhibited metabolism type II, regardless of the aeration process. The best results were obtained for 1 vvm and 250 rpm (+1, +1), with values of OD600nm (18.04) and DCW (4.82 g.L-1).

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“…Under normal growth conditions, most bacteria produce only a small amount of PHA (1–15%). When special growth conditions and fermentation strategies are applied, the synthesized PHA can reach almost 90% [ 18 ]. Medical applications require a constant and reproducible quality of PHAs, which can be achieved via bacterial production in a rigorous culture [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Silver Decorated βTCP-Poly(3hydroxybutyrate) Scaffolds for Bone Tissue Engineering

et al. 2021

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Implantations in orthopedics are associated with a high risk of bacterial infections in the surgery area. Therefore, biomaterials containing antibacterial agents, such as antibiotics, bactericidal ions or nanoparticles have been intensively investigated. In this work, silver decorated β tricalcium phosphate (βTCP)-based porous scaffolds were obtained and coated with a biopolymer—poly(3-hydroxybutyrate)-P(3HB). To the best of our knowledge, studies using silver-doped βTCP and P(3HB), as a component in ceramic-polymer scaffolds for bone tissue regeneration, have not yet been reported. Obtained materials were investigated by high-temperature X-ray diffraction, X-ray fluorescence, scanning electron microscopy with energy dispersive spectroscopy, hydrostatic weighing, compression tests and ultrahigh-pressure liquid chromatography with mass spectrometry (UHPLC-MS) measurements. The influence of sintering temperature (1150, 1200 °C) on the scaffolds’ physicochemical properties (phase and chemical composition, microstructure, porosity, compressive strength) was evaluated. Materials covered with P(3HB) possessed higher compressive strength (3.8 ± 0.6 MPa) and surgical maneuverability, sufficient to withstand the implantation procedures. Furthermore, during the hydrolytic degradation of the composite material not only pure (R)-3-hydroxybutyric acid but also its oligomers were released which may nourish surrounding tissues. Thus, obtained scaffolds were found to be promising bone substitutes for use in non-load bearing applications

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Poly(3-hydroxybutyrate)-P(3HB): Review of Production Process Technology

Cited by 32 publications

References 68 publications

Recent Advances in the Biosynthesis of Polyhydroxyalkanoates from Lignocellulosic Feedstocks

Recent Advances in the Biosynthesis of Polyhydroxyalkanoates from Lignocellulosic Feedstocks

Optimization of Ralstonia solanacearum cell growth using a central composite rotational design for the P(3HB) production: Effect of agitation and aeration

Silver Decorated βTCP-Poly(3hydroxybutyrate) Scaffolds for Bone Tissue Engineering

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