Poly(3-hydroxybutyrate): A potential biodegradable excipient for direct 3D printing of pharmaceuticals

Moroni, Sofia; Khorshid, Shiva; Aluigi, Annalisa; Tiboni, Mattia; Casettari, Luca

doi:10.1016/j.ijpharm.2022.121960

Cited by 6 publications

(7 citation statements)

References 29 publications

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“…The 3D Cultures (Philadelphia, PA, USA) have also developed a single-screw DPE 3D printer consisting of a hopper, a single-screw extruder, and a 1 mm nozzle. This 3D printer was used to develop sustained-release tablets with square geometries and transdermal patches [ 32 , 33 ].…”

Section: Resultsmentioning

confidence: 99%

“…Finally, poly (3-hydroxybutyrate) (PHB) has also been investigated as a promising alternative biopolymer for DPE [ 33 ]. This thermoplastic aliphatic polyester is biodegradable, biocompatible, and environmentally friendly, with a high crystallinity (60–70% w / w ) and a molecular weight > 400 kDa.…”

Section: Resultsmentioning

confidence: 99%

“…In relation to the materials employed in the different formulations, only in a few studies the direct extrusion of a binary mixture of drug and polymer (HPC, EVA, PCL, and PHB) is possible [ 19 , 20 , 32 , 33 , 37 ], but in most cases, the use of auxiliary excipients is needed (see Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

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3D Printing Direct Powder Extrusion in the Production of Drug Delivery Systems: State of the Art and Future Perspectives

Aguilar-de-Leyva,

Casas,

Ferrero

et al. 2024

Pharmaceutics

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The production of tailored, on-demand drug delivery systems has gained attention in pharmaceutical development over the last few years, thanks to the application of 3D printing technology in the pharmaceutical field. Recently, direct powder extrusion (DPE) has emerged among the extrusion-based additive manufacturing techniques. It is a one-step procedure that allows the direct processing of powdered formulations. The aim of this systematic literature review is to analyze the production of drug delivery systems using DPE. A total of 27 articles have been identified through scientific databases (Scopus, PubMed, and ScienceDirect). The main characteristics of the three types of 3D printers based on DPE have been discussed. The selection of polymers and auxiliary excipients, as well as the flowability of the powder mixture, the rheological properties of the molten material, and the printing temperatures have been identified as the main critical parameters for successful printing. A wide range of drug delivery systems with varied geometries and different drug release profiles intended for oral, buccal, parenteral, and transdermal routes have been produced. The ability of this technique to manufacture personalized, on-demand drug delivery systems has been proven. For all these reasons, its implementation in hospital settings in the near future seems promising.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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3D Printing Direct Powder Extrusion in the Production of Drug Delivery Systems: State of the Art and Future Perspectives

Aguilar-de-Leyva,

Casas,

Ferrero

et al. 2024

Pharmaceutics

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“…The synthetic polymers commonly used in 3D printing [101,102], which are characterized by high printability and mechanical strength, are polycaprolactone (PCL) [103][104][105], polylactic acid (PLA) [106], and poly(lactic-co-glycolic acid) (PLGA) [107], polyvinylpyrrolidone (PVP) [108], polyvinyl alcohol (PVA) [109], and novel binary and ternary polymer blends based on ABS [110], HPMC [111], and carboxymethylcellulose (CMC) [112,113].…”

Section: Polymers For 3d Printing Technologiesmentioning

confidence: 99%

Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

Ozon,

Sarbu,

Popovici

et al. 2023

Processes

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The interest in buccal drug delivery is under consideration due to some distinct properties compared to the traditional pharmaceutical formulations for oral administration: significantly higher bioavailability, a faster absorption rate of the drug, and substantial compliance for special needs patients. Oral films are obtained through various technologies, from conventional tools to 3D and 4D printing approaches. This minireview aims to describe the current additive manufacturing technologies in oral film fabrication, display their advantages and limitations, and discuss various formulation strategies. It also provides advanced data regarding synthetic and natural polymers used in 3D printing technologies for oral films. Moreover, it shows the most recent studies with 3D-printed orodispersible films and mucoadhesive buccal films manufactured through previously analyzed methods. Finally, conclusions and future perspectives are also briefly summarized.

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“…PHB is also often used as a basic compound of composite materials [ 15 , 16 , 17 , 18 ]. PHB has a number of unique biological properties: complete biodegradability to non-toxic products, biocompatibility, non-carcinogenicity, and special diffusion properties that provide sustained drug release [ 19 , 20 , 21 , 22 ]. PHB undergoes hydrolytic, enzymatic, and cellular biodegradation, and the degradation time is highly dependent on the molecular weight, crystallinity degree, and device shape and microstructure [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Poly(3-hydroxybutyrate) 3D-Scaffold–Conduit for Guided Tissue Sprouting

Zharkova

Волков

Мураев³

et al. 2023

IJMS

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Scaffold biocompatibility remains an urgent problem in tissue engineering. An especially interesting problem is guided cell intergrowth and tissue sprouting using a porous scaffold with a special design. Two types of structures were obtained from poly(3-hydroxybutyrate) (PHB) using a salt leaching technique. In flat scaffolds (scaffold-1), one side was more porous (pore size 100–300 μm), while the other side was smoother (pore size 10–50 μm). Such scaffolds are suitable for the in vitro cultivation of rat mesenchymal stem cells and 3T3 fibroblasts, and, upon subcutaneous implantation to older rats, they cause moderate inflammation and the formation of a fibrous capsule. Scaffold-2s are homogeneous volumetric hard sponges (pore size 30–300 μm) with more structured pores. They were suitable for the in vitro culturing of 3T3 fibroblasts. Scaffold-2s were used to manufacture a conduit from the PHB/PHBV tube with scaffold-2 as a filler. The subcutaneous implantation of such conduits to older rats resulted in gradual soft connective tissue sprouting through the filler material of the scaffold-2 without any visible inflammatory processes. Thus, scaffold-2 can be used as a guide for connective tissue sprouting. The obtained data are advanced studies for reconstructive surgery and tissue engineering application for the elderly patients.

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Poly(3-hydroxybutyrate): A potential biodegradable excipient for direct 3D printing of pharmaceuticals

Cited by 6 publications

References 29 publications

3D Printing Direct Powder Extrusion in the Production of Drug Delivery Systems: State of the Art and Future Perspectives

3D Printing Direct Powder Extrusion in the Production of Drug Delivery Systems: State of the Art and Future Perspectives

Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

Poly(3-hydroxybutyrate) 3D-Scaffold–Conduit for Guided Tissue Sprouting

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