Poly(2-isoproprenyl-2-oxazoline)-Based Reactive Hydrophilic Cross-Linked Nanofiber Networks as the Basis for Colorimetric Continuous Meat Freshness Monitoring Sensors

Self-indicating polymers: a pathway to intelligent materials

“…Merckx et al prepared poly(2-isoproprenyl-2-oxazoline)nanofibers with high water stability with the aid of electrospinning method. 267 They reported crosslinking of the 2-oxazoline groups and consequent yielding of nanofibrous networks by incorporation of a dicarboxylic acid functional molecule during the one-pot electrospinning process. After post-modification of the network with acid-functionalized halochromic dyes, it can be used for continuous food monitoring of biogenic food spoilage, such as thiol- and amine-containing gaseous small molecules.…”

Poly(2-isopropenyl-2-oxazoline) Hydrogels with Biodegradable Junction Points for Drug-Delivery Applications

“…Poly(2-isopropenyl-2-oxazoline) (PiPOx) is a versatile polymer platform , introduced recently for the development of various functional polymeric materials for biomedical applications, such as polymers with thermoresponsive properties, , cationic polymers for transfection of nucleic acids, and hydrogel materials. − PiPOx versatility derives from its 2-oxazoline side-chain reactive groups that can be easily and straightforward modified through reactions with carboxylic acids or thiols . Thus, the postpolymerization modifications of PiPOx represent a powerful and robust chemistry to modulate a wide range of physicochemical properties for specific applications. ,,− PiPOx has been previously shown to possess good biocompatibility and immunomodulative properties, becoming an appealing polymeric platform for applications in the biomedical field. , In a recent study, it was demonstrated that PiPOx is chemically stable in body fluids (pH 6.4–7.4, 37 °C), revealing its great potential for the development of drug-delivery applications . Moreover, our group developed a simple and robust synthetic protocol, involving the postpolymerization modification reaction of PiPOx with dicarboxylic acids, which gave access to hydrogel materials that possess a wide range of mechanical properties − , and that span from materials with applications for water purification to the biomedical field …”

Degradable Cell-Adhesive Hybrid Hydrogels by Cross-Linking of Gelatin with Poly(2-isopropenyl-2-oxazoline)

“…In contrast to other poly(2-oxazoline)s that are obtained by cationic ring-opening polymerization of the corresponding monomers, such as 2-ethyl-2-oxazoline or 2-methyl-2-oxazoline, 2-isopropenyl-2-oxazoline (iPOx) is polymerized through its alkenyl side-chain substituent, thus retaining the 2-oxazoline rings in the resulting polymer structure (Scheme A). Free radical or controlled polymerization of iPOx has been reported via anionic polymerization, reversible addition–fragmentation chain transfer, atom transfer radical polymerization, and metal-mediated group transfer polymerization. − The pendant 2-oxazoline side groups of PiPOx are available for postpolymerization reactions with carboxylic acids, allowing for modification and cross-linking. ,− The versatility of PiPOx platform has been explored for the synthesis of many polymeric networks with various applications including water purification, drug delivery, antibacterial properties, detection, and sensing. , Nevertheless, synthetic polymers such as PiPOx lack cell-adhesive properties, limiting their biomedical use. Thus, combining PiPOx with gelatin would result in hydrogels with increased mechanical stability, degradability, and cell-interactive properties as novel responsive materials.…”