Poloxamer 407‐based Floating Hydrogels for Intravesical Instillation: Statistical Optimization Using Central Composite Design, Gel Erosion, and Drug Release

Yang, Hee Mang; Yoon, Ho Yup; Kim, Chang‐Hyun; Goo, Yoon Tae; Choi, Ik Joon; Park, Sang‐Gue; Chang, In Ho; Choi, Young Wook

doi:10.1002/bkcs.12160

Cited by 9 publications

(3 citation statements)

References 30 publications

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“…Poloxamer 407, a biocompatible polymer, was utilized widely as a thermosensitive material, owing to its performance of rapid thermo-reversible sol–gel transition and the capability to stabilize sustained releasing drugs ( Bai et al, 2020a ; Hsieh et al, 2020 ). Although the surfactant function of Poloxamer 407 is beneficial to the dispersion of drugs in the hydrogels, this capacity may result in the rapid erosion of the hydrogels in several hours under physiological conditions, thus, leading to a burst release of the loaded drugs ( Tundisi et al, 2021 ; Yang et al, 2021 ). To address these limitations, HA, a biopolymer naturally presenting in the synovial fluid, was employed in this study as a carbohydrate additive for controlled release of drugs to reduce the concentration of Poloxamer 407 required for gelation.…”

Section: Resultsmentioning

confidence: 99%

Icariin-Loaded Hydrogel Regulates Bone Marrow Mesenchymal Stem Cell Chondrogenic Differentiation and Promotes Cartilage Repair in Osteoarthritis

Zhu

Cai

et al. 2022

Front. Bioeng. Biotechnol.

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Intra-articular injection of mesenchymal stem cells is a potential therapeutic strategy for cartilage protection and symptom relief for osteoarthritis (OA). However, controlling chondrogenesis of the implanted cells in the articular cavity remains a challenge. In this study, hydrogels containing different concentrations of icariin were prepared by in situ crosslinking of hyaluronic acid and Poloxamer 407. This injectable and thermoresponsive hydrogel, as a 3D cell culture system, showed good biocompatibility with chondrocytes and bone marrow mesenchymal stem cells (BMSCs), as well as promoted proliferation and chondrogenesis of BMSCs through the Wnt/β-catenin signaling pathway. Intra-articular injection of this kind of BMSC-loaded composite hydrogel can significantly prevent cartilage destruction by inducing chondrogenic differentiation of BMSCs, and relieve pain through regulating the expression of inflammatory cytokines (e.g., IL-10 and MMP-13) in the OA model. Incorporating BMSCs into this novel icariin-loaded hydrogel indicates a more superior efficacy than the single BMSC injection, which suggests a great potential for its application in OA.

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Section: Resultsmentioning

confidence: 99%

Icariin-Loaded Hydrogel Regulates Bone Marrow Mesenchymal Stem Cell Chondrogenic Differentiation and Promotes Cartilage Repair in Osteoarthritis

Zhu

Cai

et al. 2022

Front. Bioeng. Biotechnol.

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“…The erosion tests were performed using a solution of KH 2 PO 4 0.05 mM, pH 6.75 that simulate saliva, in order to obtain information regarding the residence time of the gel in the oral cavity. The micellar packing arrangement of P407, indeed, rapidly dissociates in the presence of excess aqueous media leading to the degradation of the gel matrix [37].…”

Section: Erosion Behaviors Of Gel Formulationsmentioning

confidence: 99%

Poloxamer-Based Hydrogel as Drug Delivery System: How Polymeric Excipients Influence the Chemical-Physical Properties

et al. 2022

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Thermogelling amphiphilic block copolymers have been widely investigated in the development of pharmaceutical drug carriers. In particular, thermosensitive gels based on poloxamer 407 (P407) have great potential for periodontal disease treatment, thanks to their ability to be liquid at room temperature and become viscous gels at body temperature. However, some problems, related to short in situ residence time, reduce their feasible clinical use. Thus, in order to improve the effective applicability of these materials, we studied how P407 thermogels are affected by the pH and by the inclusion of different hydrophilic polymers, used as excipients for increasing the gel stiffness. For this scope, a complete chemical-physical characterization of the synthesized gels is provided, in terms of determination of sol-gel transition temperature, viscosity and erosion degree. The data are correlated according to a statistical multivariate approach based on Principal Component Analysis and their mucoadhesion properties are also tested by Tapping mode-Atomic Force Microscopy (TM-AFM) imaging. Finally, we studied how the different P407 formulations are able to influence the release pathway of two antibacterial drugs (i.e., chlorhexidine digluconate and doxycycline hyclate) largely used in oral diseases.

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“…This design point represents the combination of the mean values of the factor levels. Yang et al [15] developed and optimized the composition of a Poloxamer 407-based floating hydrogel using the CCD. The concentrations of Poloxamer Polymers 2023, 15, 2592 3 of 13 407 and sodium bicarbonate were analyzed as the factors.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Alginate Hydrogels with High Water-Retaining Capacity

2023

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Hydrogels are very attractive materials due to their multifunctional properties. Many natural polymers, such as polysaccharides, are used for the preparation of hydrogels. The most important and commonly used polysaccharide is alginate because of its biodegradability, biocompatibility, and non-toxicity. Since the properties of alginate hydrogel and its application depend on numerous factors, this study aimed to optimize the gel composition to enable the growth of inoculated cyanobacterial crusts for suppressing the desertification process. The influence of alginate concentration (0.1–2.9%, m/v) and CaCl2 concentration (0.4–4.6%, m/v) on the water-retaining capacity was analyzed using the response surface methodology. According to the design matrix, 13 formulations of different compositions were prepared. The water-retaining capacity was defined as the system response maximized in optimization studies. The optimal composition of hydrogel with a water-retaining capacity of about 76% was obtained using 2.7% (m/v) alginate solution and 0.9% (m/v) CaCl2 solution. Fourier transform infrared spectroscopy was used for the structural characterization of the prepared hydrogels, while the water content and swelling ratio of hydrogels were determined using gravimetric methods. It was concluded that alginate and CaCl2 concentrations play the most important role regarding the gelation time, homogeneity, water content, and swelling ratio of the hydrogel.

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Poloxamer 407‐based Floating Hydrogels for Intravesical Instillation: Statistical Optimization Using Central Composite Design, Gel Erosion, and Drug Release

Cited by 9 publications

References 30 publications

Icariin-Loaded Hydrogel Regulates Bone Marrow Mesenchymal Stem Cell Chondrogenic Differentiation and Promotes Cartilage Repair in Osteoarthritis

Icariin-Loaded Hydrogel Regulates Bone Marrow Mesenchymal Stem Cell Chondrogenic Differentiation and Promotes Cartilage Repair in Osteoarthritis

Poloxamer-Based Hydrogel as Drug Delivery System: How Polymeric Excipients Influence the Chemical-Physical Properties

Preparation and Characterization of Alginate Hydrogels with High Water-Retaining Capacity

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