Pollution, Inflammation, and Vaccines: A Complex Crosstalk

Franza, Laura; Cianci, Rossella

doi:10.3390/ijerph18126330

Cited by 12 publications

(8 citation statements)

References 132 publications

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“…Lastly, emerging evidence shows that greater air pollutant exposure is associated with lower titers of neutralizing antibodies to the SARS-CoV-2 virus following vaccination [ 55 ]. Similar associations were observed with other vaccines, and it is suggested that air-pollution-induced chronic inflammation may mediate associations with vaccine efficacy [ 55 , 56 ]. We propose that epigenetics may play a role in this, regulating the increased inflammatory and decreased antibody responses.…”

Section: Epigenetic Perturbations Of Immune Pathways By Environmental...mentioning

confidence: 59%

Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical Exposures

Bulka

Enggasser

Fry

2022

Curr Envir Health Rpt

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Purpose of Review Several environmental contaminants have been implicated as contributors to COVID-19 susceptibility and severity. Immunomodulation and epigenetic regulation have been hypothesized as mediators of this relationship, but the precise underlying molecular mechanisms are not well-characterized. This review examines the evidence for epigenetic modification at the intersection of COVID-19 and environmental chemical exposures. Recent Findings Numerous environmental contaminants including air pollutants, toxic metal(loid)s, per- and polyfluorinated substances, and endocrine disrupting chemicals are hypothesized to increase susceptibility to the SARS-CoV-2 virus and the risk of severe COVID-19, but few studies currently exist. Drawing on evidence that many environmental chemicals alter the epigenetic regulation of key immunity genes and pathways, we discuss how exposures likely perturb host antiviral responses. Specific mechanisms vary by contaminant but include general immunomodulation as well as regulation of viral entry and recognition, inflammation, and immunologic memory pathways, among others. Summary Associations between environmental contaminants and COVID-19 are likely mediated, in part, by epigenetic regulation of key immune pathways involved in the host response to SARS-CoV-2.

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Section: Epigenetic Perturbations Of Immune Pathways By Environmental...mentioning

confidence: 59%

Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical Exposures

Bulka

Enggasser

Fry

2022

Curr Envir Health Rpt

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“…Nevertheless, we cannot limit human health solely to these factors, and the effectiveness of vaccine plays the most important role. Further studies are needed to confirm the relationship between vaccines, pollution, and their consequences [155].…”

Section: Significance Of the Results And Health Recommendationsmentioning

confidence: 99%

Beyond vaccination: A Cross-Sectional Study of the importance of Behavioral and Native Factors on COVID-19 Infection and Severity

Aouissi

Ababsa

Leveau

et al. 2022

Preprint

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The COVID-19 pandemic has a major impact on a global scale. Understanding the innate and lifestyle-related factors influencing the rate and severity of COVID-19 is important for making evidence-based recommendations. This cross-sectional study aimed at establishing a potential relationship between human characteristics and vulnerability/resistance to SARS-CoV-2. We hypothesize that the impact of virus is not the same due to cultural and ethnic differences. A cross-sectional study was performed using an online questionnaire. The methodology included a development of a multi-language survey, expert evaluation and data analysis. Data was collected using a 13-item pre-tested questionnaire based on a literature review. Data was statistically analyzed using the logistic regression. For a total of 1125 respondents, 332 (29.5%) were COVID-19 positive, among them 130 (11.5%) required home-based treatment, and 14 (1.2%) intensive care. The significant factors included age, physical activity and health status all found to have a significant influence on the infection (p < 0.05). The severity of infection was associated with preventive measures and tobacco (p < 0.05). This suggests the importance of behavioral factors compared to innate ones. Apparently, the individual behavior is mainly responsible for the spread of the virus. Adopting a healthy lifestyle and scrupulously observing preventive measures including vaccination would greatly limit the probability of infection and prevent the development of severe COVID-19.

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“…In our study, a healthy state is associated with a reduced probability of contracting the virus, which can demonstrate the importance of innate immunity; however, in no case should we base our recommendations totally on this. Nevertheless, we cannot limit human health solely to these factors, and the effectiveness of vaccines plays the most important role [ 134 ].…”

Section: Discussionmentioning

confidence: 99%

The Importance of Behavioral and Native Factors on COVID-19 Infection and Severity: Insights from a Preliminary Cross-Sectional Study

et al. 2022

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The COVID-19 pandemic has had a major impact on a global scale. Understanding the innate and lifestyle-related factors influencing the rate and severity of COVID-19 is important for making evidence-based recommendations. This cross-sectional study aims at establishing a potential relationship between human characteristics and vulnerability/resistance to SARS-CoV-2. We hypothesize that the impact of the virus is not the same due to cultural and ethnic differences. A cross-sectional study was performed using an online questionnaire. The methodology included the development of a multi-language survey, expert evaluation, and data analysis. Data were collected using a 13-item pre-tested questionnaire based on a literature review between 9 December 2020 and 21 July 2021. Data were statistically analyzed using logistic regression. For a total of 1125 respondents, 332 (29.5%) were COVID-19 positive; among them, 130 (11.5%) required home-based treatment, and 14 (1.2%) intensive care. The significant and most influential factors on infection included age, physical activity, and health status (p < 0.05), i.e., better physical activity and better health status significantly reduced the possibility of infection, while older age significantly increased it. The severity of infection was negatively associated with the acceptance (adherence and respect) of preventive measures and positively associated with tobacco (p < 0.05), i.e., smoking regularly significantly increases the severity of COVID-19 infection. This suggests the importance of behavioral factors compared to innate ones. Apparently, individual behavior is mainly responsible for the spread of the virus. Therefore, adopting a healthy lifestyle and scrupulously observing preventive measures, including vaccination, would greatly limit the probability of infection and prevent the development of severe COVID-19.

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Pollution, Inflammation, and Vaccines: A Complex Crosstalk

Cited by 12 publications

References 132 publications

Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical Exposures

Epigenetics at the Intersection of COVID-19 Risk and Environmental Chemical Exposures

Beyond vaccination: A Cross-Sectional Study of the importance of Behavioral and Native Factors on COVID-19 Infection and Severity

The Importance of Behavioral and Native Factors on COVID-19 Infection and Severity: Insights from a Preliminary Cross-Sectional Study

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