Pollution in the working place and social status: Co-factors in lung cancer carcinogenesis

Rajer, Mirjana; Zwitter, Matjaž; Rajer, Borut

doi:10.1016/j.lungcan.2014.06.012

Cited by 15 publications

(13 citation statements)

References 28 publications

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“…Near half of our responders were socially deprived, which is consistent with the literature, that shows lung cancer patients have a lower socio-economic status than the general population [ 12 , 39 ]. In our population, the level of deprivation may have been even higher since deprivation could be a barrier to complete the SAQ.…”

Section: Discussionsupporting

confidence: 91%

“…Synergistic carcinogenic effects of tobacco smoke with occupational exposure have also been reported [ 11 ]. Lung cancer patients have a lower socio-economic status compared with the general population [ 12 ] related to a higher prevalence of risk factors such as smoking and exposure to occupational lung carcinogens [ 4 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Systematic Screening for Occupational Exposures in Lung Cancer Patients: A Prospective French Cohort

Pérol

Charbotel

Perrier

et al. 2018

IJERPH

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Occupational lung cancers are under-reported and under-compensated worldwide. We assessed systematic screening for occupational exposure to carcinogens combining a self-administered questionnaire and an occupational consultation to improve the detection of occupational lung cancers and their compensation. Social deprivation and the costs of this investigation were estimated. Patients with lung cancer received a self-administered questionnaire to collect their job history, potential exposure to carcinogens and deprivation. A physician assessed the questionnaire and recommended an occupational consultation if necessary. During the consultation, a physician assessed if the lung cancer was work-related and, if it was, delivered a medical certificate to claim for compensation. Over 18 months, 440 patients received the self-administered questionnaire: 234 returned a completed questionnaire and a consultation was required for 120 patients. Compensation was judged possible for 41 patients. Among the 35 medical certificates delivered, 19 patients received compensation. Nearly half the patients (46%) were assessed as socially deprived and these patients took significantly longer to return the questionnaire compared with those who were not deprived. The mean cost of the process was €62.65 per patient. Our results showed a systematic self-administered questionnaire can be used to identify patients potentially exposed to carcinogens and to improve compensation.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Systematic Screening for Occupational Exposures in Lung Cancer Patients: A Prospective French Cohort

Pérol

Charbotel

Perrier

et al. 2018

IJERPH

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“…Both pathological types are more likely to occur in single women and in white patients. This could be explained by the fact that socioeconomic psychological factors and genetic diversity might play an important role in tumorigenesis and tumor progression (20)(21)(22). Several previous studies did demonstrate that marital status and ethnicities were important etiological and prognostic factors in several solid tumors, including cervical cancer (23)(24)(25)(26).…”

Section: Discussionmentioning

confidence: 99%

Small Cell Carcinoma as an Independent Prognostic Factor for Cervical Cancer Patients: A Population-Based Analysis

Wang

Song

et al. 2020

Preprint

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Background: Small cell carcinoma (SmCC) of cervix was a rare neoplasm with little recognition. Population-based study describing difference in characteristics and outcomes between SmCC and squamous cell carcinoma (SCC), usual type, was limited. Here, we used the Surveillance, Epidemiology, and End Results (SEER) database to compare SmCC with SCC and investigated the prognostic values of the clinicopathological characteristics and survival outcomes in SmCC of cervix.Methods: Patients diagnosed with cervical SmCC and SCC in SEER database from 2004-2015 were enrolled in analysis. Propensity-score matching analysis (PSM) was used to balance baseline characteristics between patients who were cervical SmCC and those who were cervical SCC. Cox regression models and Kaplan-Meier methods were conducted to analyze survival data before and after PSM. Stratified analyses were performed to investigate the risk of mortality at different stage. Results: In total, 25345 patients including 287 cervical SmCC patients and 25058 cervical SCC patients were enrolled our analysis. Both histological subtypes were more common in unmarried women and in white populations. Compared with cervical SCC patients, cervical SmCC patients showed a higher rate of larger tumor size (tumor size ≥4 cm, 33.8% vs 51.9%, P<0.001), higher grade disease (grade III-IV, 32.2% vs 58.9%, P<0.001), regional lymph node involvement (22.5% vs 49.5%, P<0.001) and distant metastasis (10.3% vs 32.4%, P<0.001). Before PSM, multivariate regression model revealed that SmCC histology (P<0.001) and advanced FIGO stages (P<0.001) were principal prognostic factors of poor survival for cervical patients. After PSM, 1060 patients in SCC group were 4:1 matched with 278 patients in SmCC group. Multivariate regression model in PSM cohort showed histology and FIGO stage were crucial prognostic factors for survival. Kaplan-Meier survival curves clearly showed that cervical SmCC patients had worse survival than that of patients with SCC in all stages, stage I-II, III, IV before and after PSM analysis.Conclusion: Compared to patients with cervical SCC, those with cervical SmCC showed a worse survival before and after adjustment baseline characteristic in all stages. SmCC was an independent poor prognostic factor in cervical cancer patients.

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“…Multiple logistic regression analysis was conducted to determine whether the risk of the symptoms of respiratory and allergic diseases and prevalence of chronic and acute diseases in the industrial area was higher than those in the control area. Potential confounding variables such as age, sex, BMI, level of education, occupational exposure to hazardous materials, and smoking status were selected based on the results of univariate analysis and previous studies [ 11 - 14 ] and were included in multiple logistic models as covariates. In addition, the key confounding variables of age (below 50 or above 50), smoking status (present or past smoker, non-smoker), and occupational exposure were subjected to stratified analyses.…”

Section: Methodsmentioning

confidence: 99%

Health effects of environmental pollution in population living near industrial complex areas in Korea

Eom

Choi

Bae

et al. 2018

Environ Health Toxicol

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Several epidemiological studies have reported an association between environmental pollution and various health conditions in individuals residing in industrial complexes. To evaluate the effects of pollution from industrial complex on human health, we performed a pooled analysis of environmental epidemiologic monitoring data for residents living near national industrial complexes in Korea. The respiratory and allergic symptoms and the prevalence of acute and chronic diseases, including cancer, were used as the outcome variables for health effects. Multiple logistic regression analysis was used to analyze the relationship between exposure to pollution from industrial complexes and health conditions. After adjusting for age, sex, smoking status, occupational exposure, level of education, and body mass index, the residents near the industrial complexes were found to have more respiratory symptoms, such as cough (odds ratio [OR], 1.18; 95% confidence interval [CI], 1.06 to 1.31) and sputum production (OR, 1.13; 95% CI, 1.03 to 1.24), and symptoms of atopic dermatitis (OR, 1.10; 95% CI, 1.01 to 1.20). Among residents of the industrial complexes, the prevalence of acute eye disorders was approximately 40% higher (OR, 1.39; 95% CI, 1.04 to 1.84) and the prevalence of lung and uterine cancer was 3.45 times and 1.88 times higher, respectively, than those among residents of the control area. This study showed that residents living in the vicinity of industrial complexes have a high risk of acute and chronic diseases including respiratory and allergic conditions. These results can be used as basic objective data for developing health management measures for individuals residing near industrial complexes.

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Pollution in the working place and social status: Co-factors in lung cancer carcinogenesis

Cited by 15 publications

References 28 publications

Systematic Screening for Occupational Exposures in Lung Cancer Patients: A Prospective French Cohort

Systematic Screening for Occupational Exposures in Lung Cancer Patients: A Prospective French Cohort

Small Cell Carcinoma as an Independent Prognostic Factor for Cervical Cancer Patients: A Population-Based Analysis

Health effects of environmental pollution in population living near industrial complex areas in Korea

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