Pollution Biomarkers in Environmental and Human Biomonitoring

Lionetto, Maria Giulia; Caricato, Roberto; Giordano, Maria Elena

doi:10.2174/1875318301909010001

Cited by 56 publications

(37 citation statements)

References 71 publications

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“…Suitable biomonitoring studies need selecting the most appropriate biomarkers, which allow the early detection of both adverse effects and sub-clinical damage. Thus, the study of biomarkers has been a subject of big interest in recent years, because of their usefulness to evaluate human exposure to pesticides, promoting intervention and prevention strategies to reduce harmful health effects (Lionetto et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Validation of exposure indexes to pesticides through the analysis of exposure and effect biomarkers in ground pesticide applicators from Argentina

Filippi

Lucero

Bonansea

et al. 2021

Heliyon

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The characterization of the population exposed to pesticides and the use of effective biomarkers to evaluate potential health effects are determinant to identify vulnerable groups, understanding the causality of diverse pathologies and propose prevention policies. This is particularly important in countries where intensive agricultural practices had an explosive expansion in last decades.The aim of this study was assessing the usefulness of two exposure indexes questionnaire-based: Intensity Level of the pesticide Exposure (ILE) and Cumulative Exposure Index (CEI) and their scales, in terrestrial applicators of pesticide from the Province of C ordoba (Argentina). The analysis was performed contrasting ILE and CEI results with perceived symptomatology, in addition to effect and exposure biomarkers. A cross-sectional study was designed to compare pesticides body burdens and effect biomarkers between subjects occupationally (OE) and non-occupationally exposed (NOE) to pesticides. Prevalence of perceived symptomatology and genotoxicity damage was higher in the OE group. The exposure condition was the only variable explaining these differences. Significant associations were found between CEI and neurologic symptomatology (p < 0.05) and between ILE and plasmatic cholinesterase (p < 0.1). However, residues of HCB, β-HCH, α-endosulfan, pp'DDE, endrin, β-endosulfan, pp'DDT, endosulfan sulfate and mirex were found in blood samples from both groups. To our knowledge, this is the first report on pesticides body burdens in occupational exposure settings in Argentina. So far, our current results indicate that the occupational condition affects the health of the workers. Significant associations found between symptomatology and biomarkers with scales of CEI and ILE suggest their usefulness to verify different levels of exposure. Further research is necessary to propose these indexes as an affordable tool for occupational health surveillance in areas with difficult access to health care centres.

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Section: Introductionmentioning

confidence: 99%

Validation of exposure indexes to pesticides through the analysis of exposure and effect biomarkers in ground pesticide applicators from Argentina

Filippi

Lucero

Bonansea

et al. 2021

Heliyon

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“…To understand how the new generation pesticide sulfoxaflor affects non-target organisms in coastal/marine environments, an ecotoxicological approach using the European green crab Carcinus maenas as a non-target model species was performed, recurring to biomarker responses [ 14 ]. Crustaceans, due to their wide distributions, sedentary life-style, and relative tolerance to contaminants, are model organisms commonly used to assess the quality of aquatic ecosystems, as reviewed in Lionetto et al [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Exposure to the Insecticide Sulfoxaflor Affects Behaviour and Biomarkers Responses of Carcinus maenas (Crustacea: Decapoda)

Damasceno

Rato

Simões

et al. 2021

Biology

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Sulfoxaflor is an insecticide belonging to the recent sulfoximine class, acting as a nicotinic acetylcholine receptor (nAChRs) agonist. There are few studies regarding sulfoxaflor’s toxicity to non-target organisms. The present study aimed to investigate the acute and sub-lethal effects of sulfoxaflor on Carcinus maenas by addressing survival, behaviour (feed intake and motricity), and neuromuscular, detoxification and oxidative stress, and energy metabolism biomarkers. Adult male green crabs were exposed to sulfoxaflor for 96 h and an LC50 of 2.88 mg L−1 was estimated. All biomarker endpoints were sampled after three (T3) and seven (T7) days of exposure and behavioural endpoints were addressed at T3 and day six (T6). Sulfoxaflor affected the feed intake and motricity of C. maenas at T6. From the integrated analysis of endpoints, with the increase in concentrations of sulfoxaflor, after seven days, one can notice a lower detoxification capacity (lower GST), higher LPO levels and effects on behaviour (higher motricity effects and lower feed intake). This integrated approach proved to be valuable in understanding the negative impacts of sulfoxaflor on green crabs, while contributing to the knowledge of this pesticide toxicity to non-target coastal invertebrates.

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“…The application of biomarkers in biomonitoring is useful for measuring a biochemical response of an animal when a pollutant causes a change to its biological state 36 . In general, these biochemical changes are responses occurring at the lower organismic levels; i.e., molecular, subcellular, cellular, histological 37 . Several biomarkers cover a range of measurable parameters for determining biological responses to marine pollution.…”

Section: Introductionmentioning

confidence: 99%

Multibiomarker Responses to Polycyclic Aromatic Hydrocarbons and Microplastics in Thumbprint Emperor Lethrinus Harak from a South Pacific Locally Managed Marine Area

Varea¹,

Paris²,

Феррейра³

et al. 2021

Preprint

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To determine the baseline threat of microplastics and polycyclic aromatic hydrocarbons (PAHs) in an important seafood fish from Vueti Navakavu LMMA, a multibiomarker risk assessment was conducted on the thumbprint emperor fish. K-factor was significantly lower in samples from the wet season compared to the dry season but no significant differences were observed for HSI between seasonal groups. PAHs levels of four metabolites in emperor fish from Fiji waters is reported here for the first time; seasonal groups showed no significant differences, but all samples presented levels of biliary PAHs. The specimens also contained at least one microplastic in its gastrointestinal system; fibres were the predominant form-type and ingestion levels showed that more than 80 % of fragment sizes were below 1.0 mm. Biochemical responses were observed for EROD and GST biotransformation activity, oxidative stress (GPX and GR activity; LPO concentration) and genotoxicity (micronuclei assay). Though there were no statistically significant differences found, there were biological significances that were important to note; relatively low levels of pollutant exposure showed low levels of biochemical responses as well, and enzymes response were as expected to their roles in the body. This reflects that a multibiomarker approach can be helpful to monitor future trends of pollution levels, and help improve or strengthen the efforts of existing conservation mechanisms such as LMMAs. Coastal communities consume 0.55 kgs more seafood fishes annually in the world, so their livelihood security and health safety should be paramount in our efforts to curb the issue. We recommend adopting new techniques, like biomonitoring, to improve the conservation mechanisms and systems in place.

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Pollution Biomarkers in Environmental and Human Biomonitoring

Cited by 56 publications

References 71 publications

Validation of exposure indexes to pesticides through the analysis of exposure and effect biomarkers in ground pesticide applicators from Argentina

Validation of exposure indexes to pesticides through the analysis of exposure and effect biomarkers in ground pesticide applicators from Argentina

Exposure to the Insecticide Sulfoxaflor Affects Behaviour and Biomarkers Responses of Carcinus maenas (Crustacea: Decapoda)

Multibiomarker Responses to Polycyclic Aromatic Hydrocarbons and Microplastics in Thumbprint Emperor Lethrinus Harak from a South Pacific Locally Managed Marine Area

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